Everything You Need to Know About This Year’s Meeting of Leaders at the UN General Assembly 

A "#UNGA" sign is on display at United Nations headquarters, Saturday, Sept. 24, 2022. (AP)
A "#UNGA" sign is on display at United Nations headquarters, Saturday, Sept. 24, 2022. (AP)
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Everything You Need to Know About This Year’s Meeting of Leaders at the UN General Assembly 

A "#UNGA" sign is on display at United Nations headquarters, Saturday, Sept. 24, 2022. (AP)
A "#UNGA" sign is on display at United Nations headquarters, Saturday, Sept. 24, 2022. (AP)

For two years, it was the coronavirus pandemic. Then, it was Russia's war in Ukraine. Throughout it all, the perils of climate change, poverty and inequality have steadily, increasingly thrummed through each convening of world leaders at the UN General Assembly.

As the 78th session opens, there's no single clear crisis set to dominate the General Debate, as none of the aforementioned ones have been resolved. The high-level meeting will be set against the backdrop of an ongoing war, new political crises in West Africa and Latin America, a lingering coronavirus, economic instability, widening inequality and fresh natural disasters in the forms of devastating earthquakes, floods and fires.

In the face of this tumult, the theme for this year's General Debate will be “Rebuilding trust and reigniting global solidarity: Accelerating action on the 2030 Agenda and its Sustainable Development Goals towards peace, prosperity, progress and sustainability for all.”

Here's what to know about this year's UN General Assembly, presided over by Trinidad and Tobago's Dennis Francis.

WHAT IS THE POINT OF THE UN GENERAL ASSEMBLY? While the effectiveness of the United Nations has been questioned for as long as it has existed, the benefits of attendance are undeniable. From the dais, countries broadcast their agendas, grievances and calls to action to the entire world and for the permanent record.

The exercise in multilateralism was born in the wake of World War II, and grounded in the hope for lasting peace. This week is a key chance for countries often drowned out by what they decry as a hegemonic world order to grab the attention of a larger audience. It’s also a chance for leaders to engage in meetings on the sidelines in neutral territory.

WHO IS COMING TO NEW YORK THIS YEAR? Heads of state and government from at least 145 countries are expected to take the dais at the river's edge. Among them will be Brazilian President Luiz Inácio Lula da Silva, US President Joe Biden and Ukrainian President Volodymyr Zelenskyy — all expected in the first day. This will be Zelenskyy's first in-person appearance at the United Nations since the Russian invasion of his country — in 2022, the General Assembly voted to grant him special dispensation to submit a prerecorded speech.

But the parade of speakers will be marked by some key absences: While they're all sending representatives, the leaders of the rest of the permanent UN Security Council members — France, the United Kingdom, China and Russia — will not make the trip. The presence of Vladimir Putin would certainly have been surprising, but Emmanuel Macron is a regular attendee and this would have been British Prime Minister Rishi Sunak's first opportunity to address the General Assembly. Macron cited King Charles III's imminent visit; Sunak, a busy schedule.

Top leaders from other major countries, including India — who just played host to the G20 summit in New Delhi this month — and Mexico, are also slated to send ministers in their steads.

WHAT DOES THE GENERAL DEBATE LOOK LIKE? We might be in the midst of US presidential primary debate season, but the structure of the General Debate at the United Nations bears little resemblance. It doesn't lend itself to obvious fireworks — booing or interruptions or immediate rebuttals are not permitted — but that doesn’t mean intrigue and drama are absent.

Each speech alone offers a rich text and the delivery adds subtext. Speeches can be fonts of evocative language, barbs and gauzily veiled messages. They're supposed to run for 15 minutes, but many miss that mark. Last year, speeches averaged around 19 minutes, drawing a wry chiding from Slovakian President Zuzana Čaputová — clocking in under 12 minutes, her speech ended with: “And since obeying even the smallest of rules matters, let me finish here to respect the agreed time limit.” The longest speech in history ran to 269 minutes, and was delivered by Cuba's Fidel Castro in 1960.

Member states are also allowed to exercise the right of reply, in which they can rebut criticism voiced during the General Debate. These are often fiery exchanges at day's end, but aren’t typically delivered by heads of state or heads of government — rather, lower-level members of a country's delegation. Last year, there were 21 exercises of the right of reply.

HOW LONG DOES THIS YEAR'S GENERAL DEBATE RUN? It's still six days, as usual, but this year's General Debate ends a day later — Tuesday, Sept. 26. While past General Debates usually ran from Tuesday through Monday, with a break only on Sunday, this year there's a two-day break. A UN spokesperson confirmed that there will be no speeches on the usually final Monday in observance of the Jewish holiday of Yom Kippur.

WHY DOES BRAZIL SPEAK FIRST AT THE UN GENERAL ASSEMBLY? It's tradition. Early on, Brazil ventured forward when no other country would volunteer to speak first. Decades later, the South American country retains the pole position. As the host country, the United States typically speaks second (though last year, President Joe Biden had to delay his speech by a day because he was attending Queen Elizabeth II's funeral).

For the scores of speeches that follow, the order is determined by multiple variables, including whom a country is sending to deliver the speech (heads of state precede heads of government, who precede mere ministers and other representatives), countries' own preferences and geographic balance.

ARE NON-UN MEMBERS ALLOWED TO ATTEND? Some. While all member states are invited to speak, not all necessarily make avail of the opportunity. But the United Nations also has permanent observers, which have access to “most meetings and relevant documentation,” per the UN website.

The European Union, Palestine and the Holy See (the Vatican) are permanent observers again on the docket this year. Last year, Palestine had the longest speech, with President Mahmoud Abbas clocking in at more than 47 minutes.



New Mpox Strain Is Changing Fast; African Scientists Are ‘Working Blind’ to Respond 

Dr. Robert Musole, medical director of the Kavumu hospital (R) consults an infant suffering from a severe form of mpox at the Kavumu hospital, 30 km north of Bukavu in eastern Democratic Republic of Congo, August 24, 2024. (AFP)
Dr. Robert Musole, medical director of the Kavumu hospital (R) consults an infant suffering from a severe form of mpox at the Kavumu hospital, 30 km north of Bukavu in eastern Democratic Republic of Congo, August 24, 2024. (AFP)
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New Mpox Strain Is Changing Fast; African Scientists Are ‘Working Blind’ to Respond 

Dr. Robert Musole, medical director of the Kavumu hospital (R) consults an infant suffering from a severe form of mpox at the Kavumu hospital, 30 km north of Bukavu in eastern Democratic Republic of Congo, August 24, 2024. (AFP)
Dr. Robert Musole, medical director of the Kavumu hospital (R) consults an infant suffering from a severe form of mpox at the Kavumu hospital, 30 km north of Bukavu in eastern Democratic Republic of Congo, August 24, 2024. (AFP)

Scientists studying the new mpox strain that has spread out of Democratic Republic of Congo say the virus is changing faster than expected, and often in areas where experts lack the funding and equipment to properly track it.

That means there are numerous unknowns about the virus itself, its severity and how it is transmitting, complicating the response, half a dozen scientists in Africa, Europe and the United States told Reuters.

Mpox, formerly known as monkeypox, has been a public health problem in parts of Africa since 1970, but received little global attention until it surged internationally in 2022, prompting the World Health Organization to declare a global health emergency. That declaration ended 10 months later.

A new strain of the virus, known as clade Ib, has the world's attention again after the WHO declared a new health emergency.

The strain is a mutated version of clade I, a form of mpox spread by contact with infected animals that has been endemic in Congo for decades. Mpox typically causes flu-like symptoms and pus-filled lesions and can kill.

Congo has had more than 18,000 suspected clade I and clade Ib mpox cases and 615 deaths this year, according to the WHO. There have also been 222 confirmed clade Ib cases in four African countries in the last month, plus a case each in Sweden and Thailand in people with a travel history in Africa.

"I worry that in Africa, we are working blindly," said Dr. Dimie Ogoina, an infectious diseases expert at Niger Delta University Hospital in Nigeria who chairs the WHO's mpox emergency committee. He first raised the alarm about potential sexual transmission of mpox in 2017, now an accepted route of spread for the virus.

"We don’t understand our outbreak very well, and if we don't understand our outbreak very well, we will have difficulty addressing the problem in terms of transmission dynamics, the severity of the disease, risk factors of the disease," Ogoina said. "And I worry about the fact that the virus seems to be mutating and producing new strains."

He said it took clade IIb in Nigeria five years or more to evolve enough for sustained spread among humans, sparking the 2022 global outbreak. Clade Ib has done the same thing in less than a year.

MUTATING 'MORE RAPIDLY'

Mpox is an orthopoxvirus, from the family that causes smallpox. Population-wide protection from a global smallpox vaccine campaign 50 years ago has waned, as the vaccinating stopped when the disease was eradicated.

Genetic sequencing of clade Ib infections, which the WHO estimates emerged mid-September 2023, show they carry a mutation known as APOBEC3, a signature of adaptation in humans.

The virus that causes mpox has typically been fairly stable and slow to mutate, but APOBEC-driven mutations can accelerate viral evolution, said Dr. Miguel Paredes, who is studying the evolution of mpox and other viruses at Fred Hutchison Cancer Center in Seattle.

"All the human-to-human cases of mpox have this APOBEC signature of mutations, which means that it's mutating a little bit more rapidly than we would expect," he said.

Paredes and other scientists said a response was complicated by several mpox outbreaks happening at once.

In the past, mpox was predominantly acquired through human contact with infected animals. That is still driving a rise in Congo in clade I cases – also known as clade Ia - likely due in part to deforestation and increased consumption of bushmeat, scientists said.

The mutated versions, clade Ib and IIb, can now essentially be considered a sexually transmitted disease, said Dr. Salim Abdool Karim, a South African epidemiologist and chair of the Africa CDC’s mpox advisory committee. Most of the mutated clade Ib cases are among adults, driven at first by an epidemic among female sex workers in South Kivu, Congo.

The virus also can spread through close contact with an infected person, which is likely how clusters of children have been infected with clade Ib, particularly in Burundi and in eastern Congo’s displacement camps, where crowded living conditions may be contributing.

Children, pregnant women and people with weakened immune systems or other illnesses may be at greater risk of serious mpox disease and death, say the WHO and mpox scientists.

Clade I has typically caused more severe disease, with fatality rates of 4%-11%, compared to around 1% for clade II. Ogoina said data from Congo suggests few have died of the new Ib version, but he feared some data is being mixed up.

More research is urgently needed, but three teams tracking mpox outbreaks in Africa say they cannot even access chemicals needed for diagnostic tests. Clade Ib can also be missed by some diagnostic tests.

Planning a response, including vaccination strategies, without this is difficult, the scientists said.

Karim said around half of cases in eastern Congo, where Ib is particularly prevalent, are only being diagnosed by doctors, with no laboratory confirmation.

Getting samples to labs is difficult because the healthcare system is already under pressure, he said. And around 750,000 people have been displaced amid fighting between the M23 rebel group and the government.

Many African laboratories cannot get the supplies they need, said Dr. Emmanuel Nakoune, an mpox expert at the Institut Pasteur in Bangui, Central African Republic, which also has clade Ia cases.

"This is not a luxury," he said, but necessary to track deadly outbreaks.