Israel's Strike on Iran: Limited Hit, Major Message

Tensions had been simmering for years between Israel and Iran. ATTA KENARE / AFP
Tensions had been simmering for years between Israel and Iran. ATTA KENARE / AFP
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Israel's Strike on Iran: Limited Hit, Major Message

Tensions had been simmering for years between Israel and Iran. ATTA KENARE / AFP
Tensions had been simmering for years between Israel and Iran. ATTA KENARE / AFP

Israel's apparent strike on Iran was deliberately limited in scope but sent a clear warning to the country's leadership about Israeli abilities to strike at sensitive targets.
Tehran refuses to recognize Israel, and for decades the two countries have waged a shadow war marked by covert Israeli operations inside Iran, and Iranian backing for anti-Israel militant groups including Hamas in Gaza and Hezbollah in Lebanon.
But while the surge in tensions over the past weeks has calmed for now, the shadow war has entered a new phase, carrying more than ever the risk of open conflict between the foes, analysts say.
The current escalation comes against the background of Hamas's October 7 attack on Israel followed by the Israeli bombing campaign in the Gaza Strip.
It began when Israel was blamed for carrying out an air strike on April 1 against Iran's consulate in Damascus, killing seven Iranian officials from the Revolutionary Guards.
Iran responded with its first-ever direct attack on Israel, involving hundreds of drones and missiles, though almost all were shot down by Israel and its allies.
Amid fears of a major Israeli retaliation to that attack, which could itself provoke another Iranian response, Israel instead chose a much more limited option in the face of US pressure.
'Remind Iran'
According to The New York Times, which cited Israeli and Iranian sources, the target was the radar system of a Russian-supplied S-300 missile defense system at an airbase in the central province of Isfahan, the region that hosts the Natanz uranium enrichment plant.
The origin of the strike is not entirely clear, but it included at least one missile fired from a warplane outside Iran and small attack drones known as quadcopters that could have been launched from inside Iran itself and were aimed at confusing air defenses, the reports said.
Israel, in line with its usual policy, has not confirmed or denied carrying out the strike on Iran or the April 1 attack in Syria.
"The purpose of the operation was precisely to remind Iran what Israel could be capable of," said Arash Azizi, senior lecturer at Clemson University in the United States.
"The choice of the airbase near Isfahan was significant because this is the main source of air defense support for all the nuclear installations in the province," he told AFP.
Israel is long believed to have carried out sabotage operations inside Iran through its Mossad espionage agency.
Most famously, according to US media reports, Iran's top nuclear scientist Mohsen Fakhrizadeh was assassinated in 2020 by Mossad using a machine gun that had been assembled close to his home by its agents and then fired remotely after they left.
According to some outlets, including television channel Iran International, Israeli agents have even captured and interrogated Revolutionary Guards inside Iran to obtain intelligence.
There have also been suspicions, after mysterious explosions around sensitive sites, that Israel has already carried out drone attacks inside Iran, but this has never been confirmed.
'Rubicon crossed'
Iranian officials have been at pains to almost laugh off the Israeli strike, with Foreign Minister Hossein Amir-Abdollahian telling NBC News the weapons used were at the "level of toys".
Iran's supreme leader Ali Khamenei, meanwhile, praised the country's armed forces for their "success".
But Alexander Grinberg, expert on Iran at the Jerusalem Institute for Strategy and Security, said Israel's choice and designation of target was in itself indicative of the presence Mossad has inside Iran.
"Israel's message is 'We can strike anywhere in Iran' given that Isfahan is in the center of Iran, relatively far away, and Israel knows exactly where it can strike," he said.
Grinberg said it was logical that Iran has not confirmed that the air base was hit: "From the moment you recognize the true scale of damage, you admit the power of the enemy."
Holly Dagres, non-resident senior fellow with the Atlantic Council, said if Israel's attack involved small quadcopters, "these small drones were likely launched from inside Iran".
This would highlight "yet another instance in which Mossad has a presence on the ground and how Iran is its playground", she said.
While the current escalation phase appears to be over, Israel could yet launch more retaliation against Iran, and tensions may also surge again if Israel launches its long-threatened offensive on Rafah in Gaza.
"In some ways, we are now back to the pre-April 1 rules of operation: the realm of gray area and unattributable operations, sabotage," said lecturer Azizi.
"That suits both Iran and Israel well. But the rubicon crossed on April 1 still matters and makes the stakes higher," he added.



New Mpox Strain Is Changing Fast; African Scientists Are ‘Working Blind’ to Respond 

Dr. Robert Musole, medical director of the Kavumu hospital (R) consults an infant suffering from a severe form of mpox at the Kavumu hospital, 30 km north of Bukavu in eastern Democratic Republic of Congo, August 24, 2024. (AFP)
Dr. Robert Musole, medical director of the Kavumu hospital (R) consults an infant suffering from a severe form of mpox at the Kavumu hospital, 30 km north of Bukavu in eastern Democratic Republic of Congo, August 24, 2024. (AFP)
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New Mpox Strain Is Changing Fast; African Scientists Are ‘Working Blind’ to Respond 

Dr. Robert Musole, medical director of the Kavumu hospital (R) consults an infant suffering from a severe form of mpox at the Kavumu hospital, 30 km north of Bukavu in eastern Democratic Republic of Congo, August 24, 2024. (AFP)
Dr. Robert Musole, medical director of the Kavumu hospital (R) consults an infant suffering from a severe form of mpox at the Kavumu hospital, 30 km north of Bukavu in eastern Democratic Republic of Congo, August 24, 2024. (AFP)

Scientists studying the new mpox strain that has spread out of Democratic Republic of Congo say the virus is changing faster than expected, and often in areas where experts lack the funding and equipment to properly track it.

That means there are numerous unknowns about the virus itself, its severity and how it is transmitting, complicating the response, half a dozen scientists in Africa, Europe and the United States told Reuters.

Mpox, formerly known as monkeypox, has been a public health problem in parts of Africa since 1970, but received little global attention until it surged internationally in 2022, prompting the World Health Organization to declare a global health emergency. That declaration ended 10 months later.

A new strain of the virus, known as clade Ib, has the world's attention again after the WHO declared a new health emergency.

The strain is a mutated version of clade I, a form of mpox spread by contact with infected animals that has been endemic in Congo for decades. Mpox typically causes flu-like symptoms and pus-filled lesions and can kill.

Congo has had more than 18,000 suspected clade I and clade Ib mpox cases and 615 deaths this year, according to the WHO. There have also been 222 confirmed clade Ib cases in four African countries in the last month, plus a case each in Sweden and Thailand in people with a travel history in Africa.

"I worry that in Africa, we are working blindly," said Dr. Dimie Ogoina, an infectious diseases expert at Niger Delta University Hospital in Nigeria who chairs the WHO's mpox emergency committee. He first raised the alarm about potential sexual transmission of mpox in 2017, now an accepted route of spread for the virus.

"We don’t understand our outbreak very well, and if we don't understand our outbreak very well, we will have difficulty addressing the problem in terms of transmission dynamics, the severity of the disease, risk factors of the disease," Ogoina said. "And I worry about the fact that the virus seems to be mutating and producing new strains."

He said it took clade IIb in Nigeria five years or more to evolve enough for sustained spread among humans, sparking the 2022 global outbreak. Clade Ib has done the same thing in less than a year.

MUTATING 'MORE RAPIDLY'

Mpox is an orthopoxvirus, from the family that causes smallpox. Population-wide protection from a global smallpox vaccine campaign 50 years ago has waned, as the vaccinating stopped when the disease was eradicated.

Genetic sequencing of clade Ib infections, which the WHO estimates emerged mid-September 2023, show they carry a mutation known as APOBEC3, a signature of adaptation in humans.

The virus that causes mpox has typically been fairly stable and slow to mutate, but APOBEC-driven mutations can accelerate viral evolution, said Dr. Miguel Paredes, who is studying the evolution of mpox and other viruses at Fred Hutchison Cancer Center in Seattle.

"All the human-to-human cases of mpox have this APOBEC signature of mutations, which means that it's mutating a little bit more rapidly than we would expect," he said.

Paredes and other scientists said a response was complicated by several mpox outbreaks happening at once.

In the past, mpox was predominantly acquired through human contact with infected animals. That is still driving a rise in Congo in clade I cases – also known as clade Ia - likely due in part to deforestation and increased consumption of bushmeat, scientists said.

The mutated versions, clade Ib and IIb, can now essentially be considered a sexually transmitted disease, said Dr. Salim Abdool Karim, a South African epidemiologist and chair of the Africa CDC’s mpox advisory committee. Most of the mutated clade Ib cases are among adults, driven at first by an epidemic among female sex workers in South Kivu, Congo.

The virus also can spread through close contact with an infected person, which is likely how clusters of children have been infected with clade Ib, particularly in Burundi and in eastern Congo’s displacement camps, where crowded living conditions may be contributing.

Children, pregnant women and people with weakened immune systems or other illnesses may be at greater risk of serious mpox disease and death, say the WHO and mpox scientists.

Clade I has typically caused more severe disease, with fatality rates of 4%-11%, compared to around 1% for clade II. Ogoina said data from Congo suggests few have died of the new Ib version, but he feared some data is being mixed up.

More research is urgently needed, but three teams tracking mpox outbreaks in Africa say they cannot even access chemicals needed for diagnostic tests. Clade Ib can also be missed by some diagnostic tests.

Planning a response, including vaccination strategies, without this is difficult, the scientists said.

Karim said around half of cases in eastern Congo, where Ib is particularly prevalent, are only being diagnosed by doctors, with no laboratory confirmation.

Getting samples to labs is difficult because the healthcare system is already under pressure, he said. And around 750,000 people have been displaced amid fighting between the M23 rebel group and the government.

Many African laboratories cannot get the supplies they need, said Dr. Emmanuel Nakoune, an mpox expert at the Institut Pasteur in Bangui, Central African Republic, which also has clade Ia cases.

"This is not a luxury," he said, but necessary to track deadly outbreaks.