The House That Grief Built

The Guise Salon in the Château de Chantilly, outside Paris, where the Duke and Duchess of Aumale had private apartments. The rooms reopened in February after a two-year restoration project. Credit: Sophie Lloyd
The Guise Salon in the Château de Chantilly, outside Paris, where the Duke and Duchess of Aumale had private apartments. The rooms reopened in February after a two-year restoration project. Credit: Sophie Lloyd
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The House That Grief Built

The Guise Salon in the Château de Chantilly, outside Paris, where the Duke and Duchess of Aumale had private apartments. The rooms reopened in February after a two-year restoration project. Credit: Sophie Lloyd
The Guise Salon in the Château de Chantilly, outside Paris, where the Duke and Duchess of Aumale had private apartments. The rooms reopened in February after a two-year restoration project. Credit: Sophie Lloyd

When visiting the newly restored private apartments of the Duke of Aumale at the Château de Chantilly outside Paris, you could easily think you were seeing the interiors of an 18th-century French castle. The rooms are sumptuous, with purple damask-covered walls, marquetry-inlaid furniture, parquet de Versailles floors and exquisitely carved boiseries, or wooden panels, depicting musical instruments and garden implements.

It all seems very grand, though these rooms were actually redone in the 19th century, but the décor is linked to utter tragedy.

In 1830, the Duke of Aumale, one of the eight children of the king, Louis Philippe d’Orléans, inherited the estate at 8, after its rightful heir was shot by a firing squad on Napoleon’s orders. The young duke attended school in Paris and chose a career in the army. He distinguished himself in military campaigns in Algeria.

In 1844, he married his cousin Marie-Caroline, the daughter of the Prince of Salerno and a grandniece of Marie Antoinette, and hired the fashionable society decorator and court painter Eugène Lami to design the interiors of the old private apartments in a ground-floor wing of the castle.

Then came the revolution of 1848. The monarchy fell, forcing the duke and his family into exile in England (with their furniture, fortunately). Chantilly was sold.

The duke could not return to France for more than 20 years, until the fall of the Second Empire in 1870, when Napoleon III was overthrown. In the meantime, the duke’s wife and older son had died in England. He returned to France only to witness his younger son die from an illness.

The duke regained ownership of Chantilly. In his grief, he re-created the old private rooms with their original contents, precisely as Lami had decorated them in the 1840s.

“These private apartments became his ‘cemetery,’ as he called them,” said Mathieu Deldicque, curator of the Condé Museum at Chantilly. “Furniture was placed precisely where it had been earlier.”

Eventually, the duke bequeathed the chateau to the Institute of France, so the décor and collections would be protected and open to the public. After his death in 1897, the private rooms were closed and remained closed until the 1990s.

Now, Mr. Deldicque has overseen the full, detailed restoration of the suite of rooms, a two-year project costing 2.5 million euros, about $2.8 million. The restoration included meticulously removing centuries of overpainting on the 18th-century boiseries, fixing the gold-inflected plaster cove ceilings, reinstalling elaborate curtains and swags, and reupholstering the furniture with elaborate trim. The rooms opened in February.

The New York Times



Scientists Produce Painstaking Wiring Diagram of a Mouse’s Brain

This image provided by the Allen Institute on April 8, 2025, shows a digital representation of neurons in a section of a mouse's brain, part of a project to create the largest map to date of brain wiring and function, in Seattle, Wash. (Forrest Collman/Allen Institute via AP)
This image provided by the Allen Institute on April 8, 2025, shows a digital representation of neurons in a section of a mouse's brain, part of a project to create the largest map to date of brain wiring and function, in Seattle, Wash. (Forrest Collman/Allen Institute via AP)
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Scientists Produce Painstaking Wiring Diagram of a Mouse’s Brain

This image provided by the Allen Institute on April 8, 2025, shows a digital representation of neurons in a section of a mouse's brain, part of a project to create the largest map to date of brain wiring and function, in Seattle, Wash. (Forrest Collman/Allen Institute via AP)
This image provided by the Allen Institute on April 8, 2025, shows a digital representation of neurons in a section of a mouse's brain, part of a project to create the largest map to date of brain wiring and function, in Seattle, Wash. (Forrest Collman/Allen Institute via AP)

Neuroscientists have produced the largest wiring diagram and functional map of a mammalian brain to date using tissue from a part of a mouse's cerebral cortex involved in vision, an achievement that could offer insight into how the human brain works.

They worked out the cerebral architecture in a tissue sample the size of a grain of sand bearing more than 200,000 cells including roughly 84,000 nerve cells, called neurons, and about 524 million connections between these neurons at junctions called synapses. In all, they collected data that covers about 3.4 miles (5.4 kilometers) of neuronal wiring in a part of the brain that processes visual information from the eyes.

"The millions of synapses and hundreds of thousands of cells come in such a diversity of shapes and sizes, and contain a massive complexity. Looking at their complexity gives, at least us, a sense of awe about the sheer complexity of our own minds," said neuroscientist Forrest Collman of the Allen Institute for Brain Science, one of the lead scientists in the research published on Wednesday in the journal Nature.

The cerebral cortex is the brain's outer layer, the main site of conscious perceptions, judgments and the planning and execution of movements.

"Scientists have been studying the structure and anatomy of the brain - including the morphology of different cell types and how they connect - for over a century. Simultaneously, they've been characterizing the function of neurons - for example, what information they process," said neuroscientist Andreas Tolias of Baylor College of Medicine, one of the research leaders.

"However, understanding how neuronal function emerges at the circuit level has been challenging, since we need to study both function and wiring in the same neurons. Our study represents the largest effort to date to systematically unify brain structure and function within a single individual mouse," Tolias added.

While there are notable differences between mouse and human brains, many organizational principles remain conserved across species.

The research focused upon a part of this region called the primary visual cortex, involved in the first stage of the brain's processing of visual information.

The research was conducted by the MICrONS, short for Machine Intelligence from Cortical Networks, a scientific consortium involving more than 150 scientists from various institutions.

Researchers at Baylor College of Medicine created a map of neural activity in a cubic millimeter of the primary visual cortex by recording brain cell responses while the laboratory mouse ran on a treadmill while watching a variety of video images, including from "The Matrix" films. The mouse had been genetically modified to make these cells emit a fluorescent substance when the neurons were active.

The same neurons were then imaged at the Allen Institute. Those images were assembled in three dimensions, and Princeton University researchers used artificial intelligence and machine learning to reconstruct the neurons and their connection patterns.

The brain is populated by a network of cells including neurons that are activated by sensory stimuli such as sight or sound or touch and are connected by synapses. Cognitive function involves the interplay between the activation of neurons and the connections among the brain cells.

The researchers see practical benefits from this type of research.

"First, understanding brain wiring rules can shed light on various neurological and psychiatric disorders, including autism and schizophrenia, which may arise from subtle wiring abnormalities. Second, knowing precisely how neuronal wiring shapes brain function allows us to uncover fundamental mechanisms of cognition," Tolias said.

One key finding highlighted in the research involved a map of how connections involving a broad class of neurons in the brain called inhibitory cells are organized. When these neurons become active, they make the cells to which they are connected less active. This stands in contrast to excitatory cells, which make the cells to which they connect more likely to become active. Inhibitory cells represent about 15% of the cortical neurons.

"We found many more highly specific patterns of inhibition than many, including us, were expecting to find," Collman said.

"Inhibitory cells don't just randomly connect to all the excitatory cells around them, but instead pick out very specific kinds of neurons to connect to. Further, it was known that there are four major kinds of inhibitory neurons in the cortex, but the patterns of specificity break up these categories into much finer groups," Collman said.