Scientists Develop New Painless Method to Deliver Insulin

 Judith Garcia, 19, fills a syringe as she prepares to give herself an injection of insulin at her home in the Los Angeles suburb of Commerce, Calif. (Reed Saxon/AP)
Judith Garcia, 19, fills a syringe as she prepares to give herself an injection of insulin at her home in the Los Angeles suburb of Commerce, Calif. (Reed Saxon/AP)
TT

Scientists Develop New Painless Method to Deliver Insulin

 Judith Garcia, 19, fills a syringe as she prepares to give herself an injection of insulin at her home in the Los Angeles suburb of Commerce, Calif. (Reed Saxon/AP)
Judith Garcia, 19, fills a syringe as she prepares to give herself an injection of insulin at her home in the Los Angeles suburb of Commerce, Calif. (Reed Saxon/AP)

Scientists from Nanyang Technological University, Singapore (NTU Singapore) and the Agency for Science, Technology and Research have showed that applying "temporal pressure" to the skin can create a new way to deliver drugs.

In a paper published in the Science Advances journal, the researchers showed that bringing together two magnets so that they pinch and apply pressure to a fold of skin, led to short term changes in the skin barrier and specifically the formation of "micro pores" underneath its surface.

In a report published Tuesday on the website of Nanyang Technological University, Lead author Daniel Lio said while needles and micro needle injections damage the skin, micro pores could pave the way towards painless transdermal delivery of drugs such as insulin.

"Our research project was first inspired by the traditional Chinese medicine 'tuina' therapy where physicians rub and apply pressure on skin and muscle tissue for treatment," explained Lio.

In tests, they showed that these micro pores, of about 3 micrometers in area, allowed drugs applied on the surface of the skin to diffuse through it more easily. Six times greater quantity of drug diffused through the skin of mice with the micro pores compared to the skin of mice which did not receive the temporal pressure treatment.

Compared to conventional injection where the skin has to be penetrated and there is a risk of a hypoglycaemia effect - when the injected insulin acts too fast and the patient gets dizzy - the new method is able to slowly deliver drugs over time without breaking the skin, thus causing less pain.

In the same report, co-author David Becker said their paper highlighted the potential to use this method which could alleviate the need for diabetes patients to inject insulin multiple times daily using conventional needles and syringes.

"Patients who have to inject drugs daily, such as insulin, are constantly asking whether there is another way to deliver their medicines that doesn't involve hurting or penetrating the skin. Our new findings hold promise for them and we hope that we can refine this method so that one day it may be possible to deliver enough drugs through the skin without pain," Becker added.



China Has Slashed Air Pollution, but the ‘War’ Isn’t Over 

This picture taken on February 11, 2026 shows pedestrians walking along an overpass as traffic snarls in Beijing. (AFP)
This picture taken on February 11, 2026 shows pedestrians walking along an overpass as traffic snarls in Beijing. (AFP)
TT

China Has Slashed Air Pollution, but the ‘War’ Isn’t Over 

This picture taken on February 11, 2026 shows pedestrians walking along an overpass as traffic snarls in Beijing. (AFP)
This picture taken on February 11, 2026 shows pedestrians walking along an overpass as traffic snarls in Beijing. (AFP)

Fifteen years ago, Beijing's Liangma riverbanks would have been smog-choked and deserted in winter, but these days they are dotted with families and exercising pensioners most mornings.

The turnaround is the result of a years-long campaign that threw China's state power behind policies like moving factories and electrifying vehicles, to improve some of the world's worst air quality.

Pollution levels in many Chinese cities still top the World Health Organization's (WHO) limits, but they have fallen dramatically since the "airpocalypse" days of the past.

"It used to be really bad," said Zhao, 83, soaking up the sun by the river with friends.

"Back then when there was smog, I wouldn't come out," she told AFP, declining to give her full name.

These days though, the air is "very fresh".

Since 2013, levels of PM2.5 -- small particulate that can enter the lungs and bloodstream -- have fallen 69.8 percent, Beijing municipality said in January.

Particulate pollution fell 41 percent nationwide in the decade from 2014, and average life expectancy has increased 1.8 years, according to the University of Chicago's Air Quality Life Index (AQLI).

China's rapid development and heavy coal use saw air quality decline dramatically by the 2000s, especially when cold winter weather trapped pollutants close to the ground.

There were early attempts to tackle the issue, including installing desulphurization technology at coal power plants, while factory shutdowns and traffic control improved the air quality for events like the 2008 Olympics.

But the impact was short-lived, and the problem worsened.

- Action plan -

Public awareness grew, heightened by factors like the US embassy in Beijing making monitoring data public.

By 2013, several international schools had installed giant inflatable domes around sport facilities to protect students.

That year, multiple episodes of prolonged haze shrouded Chinese cities, with one in October bringing northeastern Harbin to a standstill for days as PM2.5 levels hit 40 times the WHO's then-recommended standard.

The phrase "I'm holding your hand, but I can't see your face" took off online.

Later that year, an eight-year-old became the country's youngest lung cancer patient, with doctors directly blaming pollution.

As concerns mounted, China's ruling Communist Party released a ten-point action plan, declaring "a war against pollution".

It led to expanded monitoring, improved factory technology and the closure or relocation of coal plants and mines.

In big cities, vehicles were restricted and the groundwork was laid for widespread electrification.

For the first time, "quantitative air quality improvement goals for key regions within a clear time limit" were set, a 2016 study noted.

These targets were "the most important measure", said Bluetech Clean Air Alliance director Tonny Xie, whose non-profit worked with the government on the plan.

"At that time, there were a lot of debates about whether we can achieve it, because (they were) very ambitious," he told AFP.

The policy targeted several key regions, where PM2.5 levels fell rapidly between 2013 and 2017, and the approach was expanded nationwide afterwards.

"Everybody, I think, would agree that this is a miracle that was achieved in China," Xie said.

China's success is "entirely" responsible for a decline in global pollution since 2014, AQLI said last summer.

- 'Low-hanging fruits' gone -

Still, in much of China the air remains dangerous to breathe by WHO standards.

This winter, Chinese cities, including financial hub Shanghai, were regularly among the world's twenty most polluted on monitoring site IQAir.

Linda Li, a running coach who has lived in both Beijing and Shanghai, said air quality has improved, but she still loses up to seven running days to pollution in a good month.

A top environment official last year said China aimed to "basically eliminate severe air pollution by 2025", but the government did not respond when AFP asked if that goal had been met.

Official 2025 data found nationwide average PM2.5 concentrations decreased 4.4 percent on-year.

Eighty-eight percent of days featured "good" air quality.

However, China's current definition of "good" is PM2.5 levels of under 35 micrograms per cubic meter, significantly higher than the WHO's recommended five micrograms.

China wants to tighten the standard to 25 by 2035.

The last five years have also seen pollution reduction slow.

The "low-hanging fruits" are gone, said Chengcheng Qiu from the Center for Research on Energy and Clean Air (CREA).

Qiu's research suggests pollution is shifting west as heavy industry relocates to regions like Xinjiang, and that some cities in China have seen double-digit percentage increases in PM2.5 in the last five years.

"They can't just stop all industrial production. They need to find cleaner ways to produce the output," Qiu said.

There is hope for that, given China's status as a renewable energy powerhouse, with coal generation falling in 2025.

"Cleaner air ultimately rests on one clear direction," said Qiu.

"Move beyond fossil fuels and let clean energy power the next stage of development."


Sydney Man Jailed for Mailing Reptiles in Popcorn Bags 

Investigators recovered 101 Australian reptiles from parcels destined for Hong Kong, South Korea, Sri Lanka and Romania. (AFP file)
Investigators recovered 101 Australian reptiles from parcels destined for Hong Kong, South Korea, Sri Lanka and Romania. (AFP file)
TT

Sydney Man Jailed for Mailing Reptiles in Popcorn Bags 

Investigators recovered 101 Australian reptiles from parcels destined for Hong Kong, South Korea, Sri Lanka and Romania. (AFP file)
Investigators recovered 101 Australian reptiles from parcels destined for Hong Kong, South Korea, Sri Lanka and Romania. (AFP file)

A Sydney man who tried to post native lizards, dragons and other reptiles out of Australia in bags of popcorn and biscuit tins has been sentenced to eight years in jail, authorities said Tuesday.

The eight-year term handed down on Friday was a record for wildlife smuggling, federal environment officials said.

A district court in Sydney gave the man, 61-year-old Neil Simpson, a non-parole period of five years and four months.

Investigators recovered 101 Australian reptiles from seized parcels destined for Hong Kong, South Korea, Sri Lanka and Romania, the officials said in a statement.

The animals -- including shingleback lizards, western blue-tongue lizards, bearded dragons and southern pygmy spiny-tailed skinks -- were posted in 15 packages between 2018 and 2023.

"Lizards, skinks and dragons were secured in calico bags. These bags were concealed in bags of popcorn, biscuit tins and a women's handbag and placed inside cardboard boxes," the statement said.

The smuggler had attempted to get others to post the animals on his behalf but was identified by government investigators and the New South Wales police, it added.

Three other people were convicted for taking part in the crime.

The New South Wales government's environment department said that "the illegal wildlife trade is not a victimless crime", harming conservation and stripping the state "and Australia of its unique biodiversity".


Two Snowboarders Dead after Austrian Avalanche

A member of the CRS Alpes Grenoble mountain rescue team operates as he searches for potential buried victims during an avalanche emergency response rescue mission in an off-piste area of the Ecrins massif, French Alps on January 29, 2026. (Photo by JEFF PACHOUD / AFP)
A member of the CRS Alpes Grenoble mountain rescue team operates as he searches for potential buried victims during an avalanche emergency response rescue mission in an off-piste area of the Ecrins massif, French Alps on January 29, 2026. (Photo by JEFF PACHOUD / AFP)
TT

Two Snowboarders Dead after Austrian Avalanche

A member of the CRS Alpes Grenoble mountain rescue team operates as he searches for potential buried victims during an avalanche emergency response rescue mission in an off-piste area of the Ecrins massif, French Alps on January 29, 2026. (Photo by JEFF PACHOUD / AFP)
A member of the CRS Alpes Grenoble mountain rescue team operates as he searches for potential buried victims during an avalanche emergency response rescue mission in an off-piste area of the Ecrins massif, French Alps on January 29, 2026. (Photo by JEFF PACHOUD / AFP)

Two snowboarders have been confirmed dead after their bodies were recovered following an avalanche in western Austria over the weekend, police said Monday.

Avalanches across the Alps have claimed several victims in recent days following heavy snowfall.

An avalanche struck two 37-year-old off-piste snowboarders on the Stubai glacier in Tyrol province, burying them under the snow, police said in a statement.

The two Austrian men were reported missing after they had not returned from their snowboarding trip, prompting a large-scale search operation that included dogs and drones.

The buried snowboarders were located on Sunday night, but emergency services "could only confirm the death of the two men", Reuters quoted the statement as saying.

A level-four avalanche risk warning -- out of five -- is currently in place in the area following heavy snowfall in recent days.

In neighboring Italy, two skiers were killed on Sunday and another was in serious condition after an avalanche struck a slope near Courmayeur.

Avalanches have already killed several dozen people across the French, Swiss, Italian and Austrian Alps so far this season.