Does Human Growth Hormone Slow the Aging Process?

Does Human Growth Hormone Slow the Aging Process?
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Does Human Growth Hormone Slow the Aging Process?

Does Human Growth Hormone Slow the Aging Process?

Q. I haven't heard much about human growth hormone lately. Is there any new evidence to support its use in helping older men?

A. The pituitary gland in the brain makes and secretes natural growth hormone. In combination with other hormones, such as IGF-1 (insulin growth factor 1), it is responsible for body development early in life.

Throughout your life, growth hormone continues to play a role in protein production and helps the body use fat for energy. Children deficient in growth hormone do not grow to their full potential height and have short stature. The FDA approved a synthetic human growth hormone (HGH) as a replacement in these children, which helps them grow taller.

In the early 1980s, synthetic HGH became a popular but illegal performance-enhancing drug. The hype around HGH and superior athletic performance has always been greater than the reality. In fact, multiple clinical trials comparing HGH to a placebo have never shown an athletic advantage for people who use it.

As we age, the amount of growth hormone secreted by our pituitary gland naturally declines. By age 55, blood levels of growth hormone are about one-third lower than they are in people ages 18 to 35. This drop also coincides with the reduced muscle mass and increased body fat that happens with aging.

It's easy to see why HGH was touted as an "anti-aging" supplement. But does it make you feel and look 10 years younger, as some would suggest? We do know that healthy adults who take HGH can increase muscle by about 6% and reduce body fat by about the same amount. Strength also improves in some muscle groups, but not in all.

But there are downsides to using HGH. It can cause insulin to be less effective, which can raise blood sugar levels and increase the risk of diabetes. HGH also can lead to joint and muscle pain, breast enlargement, fluid retention, high blood pressure, and carpal tunnel syndrome. And then there is this: animal studies suggest that lower levels of growth hormone activity may lead to longer life. So, theoretically, HGH injections might actually shorten life span, challenging the notion that HGH is anti-aging.

The FDA has approved HGH in adults only for a few uncommon conditions, such as documented growth hormone deficiency. Synthetic human growth hormone is a prescription drug and cannot be obtained legally without a doctor's approval. To have any effect, it must be injected. Don't waste your money on pills containing HGH. The active ingredient is not absorbed when taken by mouth.

You can slow the tick of the clock with the time-tested formula of eating a healthy diet with enough protein and pursuing a regular program of aerobic and resistance exercise. This approach is better than any drug for enhancing your vigor and enjoyment of life.

by Howard LeWine, M.D.
Editor in Chief, Harvard Men's Health Watch



Elizabeth Strout, Miranda July are Among Finalists for the Women's Prize for Fiction

Yael Van Der Wouden arrives at the Booker Prize award dinner in London, Tuesday, Nov. 12, 2024. (ΑΡ Photo/Alberto Pezzali, File)
Yael Van Der Wouden arrives at the Booker Prize award dinner in London, Tuesday, Nov. 12, 2024. (ΑΡ Photo/Alberto Pezzali, File)
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Elizabeth Strout, Miranda July are Among Finalists for the Women's Prize for Fiction

Yael Van Der Wouden arrives at the Booker Prize award dinner in London, Tuesday, Nov. 12, 2024. (ΑΡ Photo/Alberto Pezzali, File)
Yael Van Der Wouden arrives at the Booker Prize award dinner in London, Tuesday, Nov. 12, 2024. (ΑΡ Photo/Alberto Pezzali, File)

American authors Elizabeth Strout and Miranda July are among finalists announced Wednesday for the Women’s Prize for Fiction, alongside four debut novelists exploring the search for freedom in different countries and cultures.

Pulitzer Prize winner Strout’s Maine-set mystery novel “Tell Me Everything” and writer'-filmmaker July’s “All Fours,” in which a “semi-famous artist” seeks a new life, are shortlisted for the 30,000 pound ($39,000) prize. It's open to female English-language writers from any country.

The contenders also include Dutch writer Yael van der Wouden’s postwar story “The Safekeep” and German-born poet Aria Aber’s novel “Good Girl,” about a teenager exploring her dual German-Afghan heritage.

Also on the list are Iran-born writer Sanam Mahloudji’s intergenerational family saga “The Persians,” and “Fundamentally” by Britain's Nussaibah Younis, about an academic trying to rehabilitate women caught up with ISIS, The AP news reported.

Author Kit de Waal, who is chairing the panel of judges, said that the six books were “classics of the future” that explored “the importance of human connection.”

“What is surprising and refreshing is to see so much humor, nuance and lightness employed by these novelists to shed light on challenging concepts,” she said.

Previous winners of the fiction prize, founded in 1996, include Zadie Smith, Tayari Jones and Barbara Kingsolver.

Last year, award organizers launched a companion Women’s Prize for Nonfiction to help rectify an imbalance in publishing. In 2022, only 26.5% of nonfiction books reviewed in Britain’s newspapers were by women, and male writers dominated established nonfiction writing prizes.

Winners of both nonfiction and fiction prizes will be announced on June 12 at a ceremony in London.