Does Human Growth Hormone Slow the Aging Process?

Does Human Growth Hormone Slow the Aging Process?
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Does Human Growth Hormone Slow the Aging Process?

Does Human Growth Hormone Slow the Aging Process?

Q. I haven't heard much about human growth hormone lately. Is there any new evidence to support its use in helping older men?

A. The pituitary gland in the brain makes and secretes natural growth hormone. In combination with other hormones, such as IGF-1 (insulin growth factor 1), it is responsible for body development early in life.

Throughout your life, growth hormone continues to play a role in protein production and helps the body use fat for energy. Children deficient in growth hormone do not grow to their full potential height and have short stature. The FDA approved a synthetic human growth hormone (HGH) as a replacement in these children, which helps them grow taller.

In the early 1980s, synthetic HGH became a popular but illegal performance-enhancing drug. The hype around HGH and superior athletic performance has always been greater than the reality. In fact, multiple clinical trials comparing HGH to a placebo have never shown an athletic advantage for people who use it.

As we age, the amount of growth hormone secreted by our pituitary gland naturally declines. By age 55, blood levels of growth hormone are about one-third lower than they are in people ages 18 to 35. This drop also coincides with the reduced muscle mass and increased body fat that happens with aging.

It's easy to see why HGH was touted as an "anti-aging" supplement. But does it make you feel and look 10 years younger, as some would suggest? We do know that healthy adults who take HGH can increase muscle by about 6% and reduce body fat by about the same amount. Strength also improves in some muscle groups, but not in all.

But there are downsides to using HGH. It can cause insulin to be less effective, which can raise blood sugar levels and increase the risk of diabetes. HGH also can lead to joint and muscle pain, breast enlargement, fluid retention, high blood pressure, and carpal tunnel syndrome. And then there is this: animal studies suggest that lower levels of growth hormone activity may lead to longer life. So, theoretically, HGH injections might actually shorten life span, challenging the notion that HGH is anti-aging.

The FDA has approved HGH in adults only for a few uncommon conditions, such as documented growth hormone deficiency. Synthetic human growth hormone is a prescription drug and cannot be obtained legally without a doctor's approval. To have any effect, it must be injected. Don't waste your money on pills containing HGH. The active ingredient is not absorbed when taken by mouth.

You can slow the tick of the clock with the time-tested formula of eating a healthy diet with enough protein and pursuing a regular program of aerobic and resistance exercise. This approach is better than any drug for enhancing your vigor and enjoyment of life.

by Howard LeWine, M.D.
Editor in Chief, Harvard Men's Health Watch



Cologne Starts Its Biggest Evacuation Since 1945 To Defuse WWII Bombs 

One of the three unexploded bombs from the Second World War is fenced off with screens as specialists prepare to defuse them in Cologne, Tuesday, June 3, 2025. (Thomas Banneyer/dpa via AP)
One of the three unexploded bombs from the Second World War is fenced off with screens as specialists prepare to defuse them in Cologne, Tuesday, June 3, 2025. (Thomas Banneyer/dpa via AP)
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Cologne Starts Its Biggest Evacuation Since 1945 To Defuse WWII Bombs 

One of the three unexploded bombs from the Second World War is fenced off with screens as specialists prepare to defuse them in Cologne, Tuesday, June 3, 2025. (Thomas Banneyer/dpa via AP)
One of the three unexploded bombs from the Second World War is fenced off with screens as specialists prepare to defuse them in Cologne, Tuesday, June 3, 2025. (Thomas Banneyer/dpa via AP)

More than 20,000 residents were being evacuated from part of Cologne's city center on Wednesday as specialists prepared to defuse three unexploded US bombs from World War II that were unearthed earlier this week.

Even 80 years after the end of the war, unexploded bombs dropped during wartime air raids are frequently found in Germany.

Disposing of them sometimes entails large-scale precautionary evacuations such as the one on Wednesday, though the location this time was unusually prominent and this is Cologne's biggest evacuation since 1945. There have been bigger evacuations in other cities.

Authorities on Wednesday morning started evacuating about 20,500 residents from an area within a 1,000-meter (3,280-foot) radius of the bombs, which were discovered on Monday during preparatory work for road construction. They were found in the Deutz district, just across the Rhine River from Cologne's historic center.

As well as homes, the area includes 58 hotels, nine schools, several museums and office buildings and the Messe/Deutz train station.

It also includes three bridges across the Rhine, among them the heavily used Hohenzollern railway bridge, which leads into Cologne's central station and is being shut during the defusal work itself.

Shipping on the Rhine will also be suspended.

The plan is for the bombs to be defused during the course of the day. When exactly that happens depends on how long it takes for authorities to be sure that everyone is out of the evacuation zone.