Does Human Growth Hormone Slow the Aging Process?

Does Human Growth Hormone Slow the Aging Process?
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Does Human Growth Hormone Slow the Aging Process?

Does Human Growth Hormone Slow the Aging Process?

Q. I haven't heard much about human growth hormone lately. Is there any new evidence to support its use in helping older men?

A. The pituitary gland in the brain makes and secretes natural growth hormone. In combination with other hormones, such as IGF-1 (insulin growth factor 1), it is responsible for body development early in life.

Throughout your life, growth hormone continues to play a role in protein production and helps the body use fat for energy. Children deficient in growth hormone do not grow to their full potential height and have short stature. The FDA approved a synthetic human growth hormone (HGH) as a replacement in these children, which helps them grow taller.

In the early 1980s, synthetic HGH became a popular but illegal performance-enhancing drug. The hype around HGH and superior athletic performance has always been greater than the reality. In fact, multiple clinical trials comparing HGH to a placebo have never shown an athletic advantage for people who use it.

As we age, the amount of growth hormone secreted by our pituitary gland naturally declines. By age 55, blood levels of growth hormone are about one-third lower than they are in people ages 18 to 35. This drop also coincides with the reduced muscle mass and increased body fat that happens with aging.

It's easy to see why HGH was touted as an "anti-aging" supplement. But does it make you feel and look 10 years younger, as some would suggest? We do know that healthy adults who take HGH can increase muscle by about 6% and reduce body fat by about the same amount. Strength also improves in some muscle groups, but not in all.

But there are downsides to using HGH. It can cause insulin to be less effective, which can raise blood sugar levels and increase the risk of diabetes. HGH also can lead to joint and muscle pain, breast enlargement, fluid retention, high blood pressure, and carpal tunnel syndrome. And then there is this: animal studies suggest that lower levels of growth hormone activity may lead to longer life. So, theoretically, HGH injections might actually shorten life span, challenging the notion that HGH is anti-aging.

The FDA has approved HGH in adults only for a few uncommon conditions, such as documented growth hormone deficiency. Synthetic human growth hormone is a prescription drug and cannot be obtained legally without a doctor's approval. To have any effect, it must be injected. Don't waste your money on pills containing HGH. The active ingredient is not absorbed when taken by mouth.

You can slow the tick of the clock with the time-tested formula of eating a healthy diet with enough protein and pursuing a regular program of aerobic and resistance exercise. This approach is better than any drug for enhancing your vigor and enjoyment of life.

by Howard LeWine, M.D.
Editor in Chief, Harvard Men's Health Watch



Indonesia: Residents Wear Masks as Volcanic Ash Blankets Villages Near Erupting Volcano

A handout photo made available by Indonesia's Volcanology and Geological Hazard Mitigation Center (PVMBG) shows Mount Lewitobi Lake-laki spewing ash during its eruption in East Flores, Indonesia, 07 July 2025. EPA/PVMBG HANDOUT
A handout photo made available by Indonesia's Volcanology and Geological Hazard Mitigation Center (PVMBG) shows Mount Lewitobi Lake-laki spewing ash during its eruption in East Flores, Indonesia, 07 July 2025. EPA/PVMBG HANDOUT
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Indonesia: Residents Wear Masks as Volcanic Ash Blankets Villages Near Erupting Volcano

A handout photo made available by Indonesia's Volcanology and Geological Hazard Mitigation Center (PVMBG) shows Mount Lewitobi Lake-laki spewing ash during its eruption in East Flores, Indonesia, 07 July 2025. EPA/PVMBG HANDOUT
A handout photo made available by Indonesia's Volcanology and Geological Hazard Mitigation Center (PVMBG) shows Mount Lewitobi Lake-laki spewing ash during its eruption in East Flores, Indonesia, 07 July 2025. EPA/PVMBG HANDOUT

Residents wore masks to protect themselves from thick volcanic ash that blanketed roads and green rice fields in villages in south-central Indonesia as rumbling Mount Lewotobi Laki Laki erupted Tuesday for a second straight day.

The eruption at dawn sent lava and clouds of ash up to 4 kilometers (2.4 miles) high. That followed an eruption around midday Monday that sent a column of volcanic materials up to 18 kilometers (11 miles) into the sky and an evening burst that spewed lava and send volcanic ash as high as 13 kilometers (8 miles) into the air, The Associated Press reported.

Photos and videos circulating on social media showed terrified residents ran for their lives under the rain of ash and gravel and motorists struggled to drive motorbikes and cars in the reduced visibility as the ash clouds from Monday's eruption expanded into a mushroom shape.

No casualties have been reported from the latest eruptions of the volcano that has been at the highest alert level since June 18 when its no-go zone was expanded to a 7-kilometer (4.3-mile) radius, said Abdul Muhari, the National Disaster Mitigation Agency spokesperson.

“People around the volcano have increasingly understood how to minimize the impact of disaster risks as eruptions became more frequent since the end of 2023,” Muhari said in a statement.

The eruptions of the volcano on Flores Island affected more than 10,000 people in 10 villages in East Flores and Sikka districts, according to initial assessments by the local disaster management agency.

Thick volcanic ash and rocks were reported to have fallen in villages of Nawakote, Klantanio, Hokeng Jaya, Boru, Pululera and Wulanggitang, where roads and green rice fields were transformed into grey thick mud and rocks, said Very Awales, an public information official at Sikka district administration, adding that schools were closed in those affected areas since Monday to protect students and staff from various hazards due to volcanic activities.

“The smell of sulfur and ash hung so thickly in the air that breathing was painful,” Awales said.

Authorities distributed 50,000 masks and urged residents to limit outdoor activities to protect themselves from volcanic materials. Residents were also urged to be vigilant about heavy rainfall that could trigger lava flows in rivers originating from the volcano.

The eruption of Lewotobi Laki Laki followed its eruption in November 2024 that killed nine people and injured dozens.

The Geology Agency recorded an avalanche of searing gas clouds mixed with rocks and lava traveling up to 5 kilometers (3 miles) down the slopes of the 1,584-meter (5,197-foot) mountain Monday. Observations from drones showed lava filling the crater, indicating deep movement of magma that set off volcanic earthquakes. Volcanic materials, including hot thumb-size gravel, were thrown up to 8 kilometers (5 miles) from the crater.

Muhari said two airports in the cities of Maumere and Larantuka in East Nusa Tenggara province remained closed Tuesday.

Dozens of flights to and from the Ngurah Rai international airport on the resort island of Bali were delayed or canceled, but airport spokesperson Ahmad Syaugi Shahab said the airport was running normally despite the cancellations, as monitoring showed the volcanic ash had not affected Bali’s airspace.