Dubai-based Emirates has suspended flights to Australia's three largest cities.
The carrier was one of the last to maintain routes into and out of the country's east coast throughout most of the pandemic but on Friday evening told travelers a handful of planned flights next week would be the last.
"Due to operational reasons, Emirates flights to/from Sydney, Brisbane and Melbourne will be suspended until further notice," Emirates said on its website.
The airline will still run two flights a week to Perth.
Australia's borders have effectively been closed since March to curb the spread of the coronavirus, with the government even limiting the number of citizens allowed to return.
Last week travel restrictions were further tightened, with arrival numbers slashed and all travelers into the country requiring a negative Covid-19 test before flying.
In making the changes, Prime Minister Scott Morrison cited a growing number of people in quarantine testing positive for new strains of Covid-19.
