Magical Effects of Psychedelics Can Transform Psychiatry

Illustrative Ecstasy pills. (AP)
Illustrative Ecstasy pills. (AP)
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Magical Effects of Psychedelics Can Transform Psychiatry

Illustrative Ecstasy pills. (AP)
Illustrative Ecstasy pills. (AP)

Imagine a medicine that could help people process disturbing memories, sparking behavioral changes rather than merely burying and suppressing symptoms and trauma. For the millions suffering with post-traumatic stress disorder (PTSD) and depression, such remedies for their daily struggles could be on the horizon. Psychiatry is rapidly heading towards a new frontier – and it's all thanks to psychedelics, The Guardian reported.

In an advanced phase trial published in Nature in May, patients in the US, Israel and Canada who received doses of the psychedelic stimulant Ecstasy (MDMA), alongside care from a therapist, were more than twice as likely as the placebo group to no longer have PTSD - for which there is currently no effective treatment - months later.

The researchers concluded that the findings, which reflected those of six earlier-stage trials, cemented the treatment as a startlingly successful potential breakthrough therapy. There are now hopes that MDMA therapy could receive approval for certain treatments from US regulators by 2023, or perhaps even earlier – with psilocybin, the active ingredient of magic mushrooms, not far behind in the process. A small study at Johns Hopkins University, published last year, suggested it could be four times more effective than traditional antidepressants.

You could say interest in psychedelics is mushrooming. Last month, in a first for psychedelics since the war on drugs was launched in the 1970s, US federal funding was granted for a psilocybin study to treat tobacco addiction following pressure by lawmakers, including Alexandria Ocasio-Cortez.

This marks a jaw-dropping turnaround for hallucinogenic drugs. Even 10 years ago, they were effectively taboo in many academic fields and halls of power. But as the intellectual rationale behind the war on drugs has become increasingly untenable, hundreds of millions of dollars have been pumped into psychedelic pharmaceutical research.



Italy Oyster Farmers Dream of Pearls from Warming Mediterranean 

A pearl oyster called Pinctada radiata is shown next to a farming site in the gulf of poets at La Spezia, Italy, August 29, 2024. (Paolo Varrella/Handout via Reuters) 
A pearl oyster called Pinctada radiata is shown next to a farming site in the gulf of poets at La Spezia, Italy, August 29, 2024. (Paolo Varrella/Handout via Reuters) 
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Italy Oyster Farmers Dream of Pearls from Warming Mediterranean 

A pearl oyster called Pinctada radiata is shown next to a farming site in the gulf of poets at La Spezia, Italy, August 29, 2024. (Paolo Varrella/Handout via Reuters) 
A pearl oyster called Pinctada radiata is shown next to a farming site in the gulf of poets at La Spezia, Italy, August 29, 2024. (Paolo Varrella/Handout via Reuters) 

Pearls may soon be cultivated in European seas for the first time ever, as Italian oyster farmers seek to exploit an unexpected opportunity offered by the rapidly warming Mediterranean.

In late 2023, the first specimens of Pinctada radiata, a pearl oyster native to the Red Sea, were spotted in the Gulf of Poets, a popular tourist area around 100 kilometers (62 miles) from Genoa on Italy's north-western coast.

Less than a year later, they are proliferating in what have always been some of the Mediterranean's coldest waters, more normally associated with other types of oyster used for food rather than jewellery.

"We are looking into the possibility of producing cultivated pearls here," said Paolo Varrella, the head of a cooperative that has been breeding food oysters in the area since 2011.

The group has already made contact with pearl oyster farmers in Mexico to get tips on production techniques, Varrella said.

"The Pinctada radiata has been reported in the Ionian Sea around the island of Sicily since the 1970s, but only in the last decade has it moved north" to the cooler Tyrrhenian and Ligurian seas that lap the western Italian mainland, said Salvatore Giacobbe, professor of ecology at the University of Messina.

It is the latest in a succession of alien warm-water species to enter the Mediterranean as it heats up due to climate change.

Manuela Falautano, a scientist at the Italian environmental research and protection institute ISPRA, said this trend had seen "an exponential increase" in the last decade.

Some of these species are aggressive and disrupt delicate ecosystems. In a few cases, such the spotted puffer fish and the scorpion fish, they are also dangerous to humans.

The 2.5 million square kilometer (970,000 square mile) expanse of water that separates southern Europe from Africa and the Middle East is heating up faster than the average of the world's seas, Falautano said.

BIG MONEY

Pearl production, more readily associated with Polynesian atolls than the northern Mediterranean, has an annual global turnover of 11 billion dollars, and Italian oyster farmers are keen to cash in.

Adriano Genisi, a pearl importer for more than 30 years, said the Radiata may produce gems similar to Japan's renowned "Akoya" pearls which have a diameter of 5-9 millimeters and a white color with shades of grey, pink and green.

If all goes well the first pearls could be harvested in about a year, he said.

The rising temperature of the Mediterranean is also blamed for an increase in violent storms such as the one that sank the luxury yacht of British tech entrepreneur Mike Lynch off Sicily last month, killing six passengers and the boat's cook.

Franco Reseghetti, a researcher at Italy's National Institute for Geophysics and Vulcanology, said measurements taken in the Tyrrhenian in December at depths of between 300 and 800 meters showed the highest temperatures since 2013, and he expected to see a further increase this year.

"The huge amount of energy behind this heating can act as a fuel for devastating atmospheric phenomena" such as the violent storm which appeared to have sunk the yacht off Sicily, Reseghetti said.