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GSK Halts 3 Trials of Respiratory Virus Vaccine in Pregnant Women

GSK logo is displayed in this illustration taken January 17, 2022. (Reuters)
GSK logo is displayed in this illustration taken January 17, 2022. (Reuters)
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GSK Halts 3 Trials of Respiratory Virus Vaccine in Pregnant Women

GSK logo is displayed in this illustration taken January 17, 2022. (Reuters)
GSK logo is displayed in this illustration taken January 17, 2022. (Reuters)

Britain's GSK said on Monday it had halted enrollment and vaccination in three trials of its experimental vaccine against the respiratory syncytial virus (RSV) in pregnant women, the latest setback in developing a vaccine for the microbe.

GSK said on Feb. 18 that it had paused a late-stage trial, dubbed "GRACE," as well as two other studies, based on safety recommendations from an independent committee but did not give further details on what had prompted the recommendations.

RSV is a leading cause of pneumonia in toddlers and the elderly, but vaccine development has been plagued by setbacks for decades. However, many drugmakers are now working to bring a candidate to the market over the next few years.

GSK, the world's biggest vaccine maker by sales, reiterated on Monday that the halts did not affect another trial of its RSV vaccine candidate for adults aged 60 and over, adding that analysis of the safety data from the maternal trials is ongoing.

RSV vaccines are seen as an opportunity for GSK to deliver on pledges to boost its drug development success rate, where it has long lagged industry peers. GSK's shot for pregnant women was aimed at conferring immunity to protect unborn children.

Its vaccine for the elderly, another major vulnerable population, has been regarded by analysts as a potential big RSV market, with trial results expected in the first half this year.

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Warm Clothing, Hot Pot and Even Ice Cream Bars Feature at China’s Ice Capital

Visitors tour by the ice structures during the Harbin Ice and Snow World in Harbin, China's Heilongjiang province on Monday, Jan. 6, 2025. (AP)
Visitors tour by the ice structures during the Harbin Ice and Snow World in Harbin, China's Heilongjiang province on Monday, Jan. 6, 2025. (AP)
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Warm Clothing, Hot Pot and Even Ice Cream Bars Feature at China’s Ice Capital

Visitors tour by the ice structures during the Harbin Ice and Snow World in Harbin, China's Heilongjiang province on Monday, Jan. 6, 2025. (AP)
Visitors tour by the ice structures during the Harbin Ice and Snow World in Harbin, China's Heilongjiang province on Monday, Jan. 6, 2025. (AP)

Faced with temperatures dipping to -30 Celsius (-22 Fahrenheit), visitors to China's wintertime resort city of Harbin often make a beeline for stalls selling padded clothing to augment their wardrobes.

Oddly perhaps for some, frozen ice cream bars are also considered a key part of the visit.

Each winter, the industrial city in China's northeast turns into a magnet for those from China's balmier regions wanting to experience the extreme cold and take in the sculptures built from ice blocks carved from the Songhua River, which freezes from late October to late March.

“I searched for tips on the internet and am now wearing knitted wool pants and the thickest sweater possible,” said Jin Yiting, who was visiting with her parents from the financial hub of Shanghai, where a light jacket is usually sufficient winter garb.

Jin Yanlong runs a stall selling winter hats, gloves and boots in the park. He said that most of his customers are tourists from southern China who underestimate the frigid weather in Harbin.

“Some of the tourists wear ‘too thin.’ They come here immediately from the airport. They would find us to buy warm trousers padded with cotton,” Jin said.

Despite the freezing weather, some curious tourists are brave enough to taste the cold itself. Zhuang Chang and his friend enjoyed their Madie’er ice cream bars while strolling on a commercial street whose architecture reflects the Russian influence on the city. The brand was established in 1900s by a Russian company and has steadily grown in popularity among tourists.

“It’s cold, but my heart is warm,” Zhuang said. He also compared the humid cold months of his hometown in Zhejiang province, where “people would be frozen to the core when being hit by wind.”

“But here only my hands and face feel cold,” Zhuang said.

For those seeking a warmer alternative, there are hot drinks and steaming hot pot, a kind of stew mixing meat, vegetables, tofu and other favorites.

Restaurant owner Chi Xuewen claims to own the world's largest hot pot, where 18 individual pots featuring a variety of flavors circle the giant bowl.

“Eating anything in a hot pot makes people warm,” Chi said.

Li Long’s restaurant uses wood both to cook the food and warm the air in the ice block structure.

“The pot also radiates heat,” Li said. “Once the pot cover is lifted, customers see the hot food. In one word, it just feels hot.”

Prolonged cold has left local residents with few options for fresh vegetables, so frozen food has become an alternative. Frozen tofu left outside overnight becomes porous and is particularly good at soaking up soup and flavor, local resident Liu Xiaohui said.