Herbal Compound Helps Reduce Tumor Cells in Mice

Research assistant Katie McCullough holds up a mouse for Jake Litvag, 16, to see inside a Washington University lab (AP)
Research assistant Katie McCullough holds up a mouse for Jake Litvag, 16, to see inside a Washington University lab (AP)
TT

Herbal Compound Helps Reduce Tumor Cells in Mice

Research assistant Katie McCullough holds up a mouse for Jake Litvag, 16, to see inside a Washington University lab (AP)
Research assistant Katie McCullough holds up a mouse for Jake Litvag, 16, to see inside a Washington University lab (AP)

The active compound in Chinese herbs called emodin, also found in some fruits and vegetables, can reduce colon cancer cells in mice, according to researchers at the University of South Carolina School of Medicine.

Physiologists conducting this study involving mice say this is likely due to emodin's ability to reduce the number of pro-tumor macrophages (a type of immune cell that can promote tumorigenesis). The new study was published by the American Physical Society (APS) ahead of print in the American Journal of Physiology-Gastrointestinal and Liver Physiology.

The researchers studied two groups of mice, one of them was treated with emodin. The results showed that mice treated with emodin "exhibited lower protumorigenic M2-like macrophages in the colon."

The team hope their findings could be used soon in human therapeutics.

Colon cancer is the third most common cancer in men and women, and the third leading cause of cancer-related deaths in the US, according to the US Centers for Disease Control and Prevention. It is expected to cause more than 52,000 deaths in the US in 2022.

According to the American Cancer Society, colon cancer risk factors include obesity, physical inactivity, diets high in red meat, smoking, and alcohol use.

“Approximately 70% of colon cancer cases can be attributed to diet or other lifestyle factors. This study raises hope that daily consumption of fresh fruits and vegetables containing emodin could prevent colon cancer in humans,” said Angela Murphy, co-author of the study from the department of pathology, microbiology, and immunology at the University of South Carolina School of Medicine.



India’s Monsoon Rains Arrive 8 Days Early, Earliest in 16 Years

Dark monsoon clouds hover over the city skyline in Mumbai on May 22, 2025. (AFP)
Dark monsoon clouds hover over the city skyline in Mumbai on May 22, 2025. (AFP)
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India’s Monsoon Rains Arrive 8 Days Early, Earliest in 16 Years

Dark monsoon clouds hover over the city skyline in Mumbai on May 22, 2025. (AFP)
Dark monsoon clouds hover over the city skyline in Mumbai on May 22, 2025. (AFP)

Monsoon rains hit the coast of India's southernmost state of Kerala on Saturday, eight days earlier than usual, marking the earliest arrival in 16 years and providing the promise of a bumper harvest and relief from a grueling heatwave.

The monsoon, the lifeblood of the country's $4 trillion economy, delivers nearly 70% of the rain that India needs to water farms and replenish aquifers and reservoirs. Nearly half of India's farmland, without any irrigation cover, depends on the annual June-September rains to grow a number of crops.

Summer rains usually begin to lash Kerala around June 1 before spreading nationwide by mid-July, allowing farmers to plant crops such as rice, corn, cotton, soybeans and sugarcane.

The onset of the southwest monsoon over Kerala on May 24 is its earliest onset since May 23, 2009, the India Meteorological Department (IMD) said on Saturday.

The monsoon has covered Kerala and parts of neighboring Tamil Nadu and Karnataka, as well as parts of the northeastern state of Mizoram, the IMD said.

Conditions are favorable for the monsoon's further spread into Goa, parts of Maharashtra, Andhra Pradesh, the northeastern states, West Bengal, and the remaining parts of Karnataka and Tamil Nadu over the next 2 to 3 days.

Surplus pre-monsoon rainfall and an early monsoon onset will help farmers, especially in the southern and central states, to sow summer crops earlier than usual, said Ashwini Bansod, vice president for commodities research at Phillip Capital India, a Mumbai-based brokerage.

"Abundant soil moisture and early sowing could potentially boost crop yields," Bansod said.

Last year, the monsoon reached the coast of Kerala on May 30, and overall summer rains were the highest since 2020, supporting recovery from a drought in 2023.

The IMD last month forecast above-average monsoon rains for the second straight year in 2025.

The department defines average or normal rainfall as ranging between 96% and 104% of a 50-year average of 87 cm (35 inches) for the four-month season.