Herbal Compound Helps Reduce Tumor Cells in Mice

Research assistant Katie McCullough holds up a mouse for Jake Litvag, 16, to see inside a Washington University lab (AP)
Research assistant Katie McCullough holds up a mouse for Jake Litvag, 16, to see inside a Washington University lab (AP)
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Herbal Compound Helps Reduce Tumor Cells in Mice

Research assistant Katie McCullough holds up a mouse for Jake Litvag, 16, to see inside a Washington University lab (AP)
Research assistant Katie McCullough holds up a mouse for Jake Litvag, 16, to see inside a Washington University lab (AP)

The active compound in Chinese herbs called emodin, also found in some fruits and vegetables, can reduce colon cancer cells in mice, according to researchers at the University of South Carolina School of Medicine.

Physiologists conducting this study involving mice say this is likely due to emodin's ability to reduce the number of pro-tumor macrophages (a type of immune cell that can promote tumorigenesis). The new study was published by the American Physical Society (APS) ahead of print in the American Journal of Physiology-Gastrointestinal and Liver Physiology.

The researchers studied two groups of mice, one of them was treated with emodin. The results showed that mice treated with emodin "exhibited lower protumorigenic M2-like macrophages in the colon."

The team hope their findings could be used soon in human therapeutics.

Colon cancer is the third most common cancer in men and women, and the third leading cause of cancer-related deaths in the US, according to the US Centers for Disease Control and Prevention. It is expected to cause more than 52,000 deaths in the US in 2022.

According to the American Cancer Society, colon cancer risk factors include obesity, physical inactivity, diets high in red meat, smoking, and alcohol use.

“Approximately 70% of colon cancer cases can be attributed to diet or other lifestyle factors. This study raises hope that daily consumption of fresh fruits and vegetables containing emodin could prevent colon cancer in humans,” said Angela Murphy, co-author of the study from the department of pathology, microbiology, and immunology at the University of South Carolina School of Medicine.



Should You Stretch before Exercise? After? Never? Here’s What to Know

 Philadelphia Eagles stretch as they get ready during practice at NFL football training camp, Thursday, July 25, 2024, in Philadelphia. (AP)
Philadelphia Eagles stretch as they get ready during practice at NFL football training camp, Thursday, July 25, 2024, in Philadelphia. (AP)
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Should You Stretch before Exercise? After? Never? Here’s What to Know

 Philadelphia Eagles stretch as they get ready during practice at NFL football training camp, Thursday, July 25, 2024, in Philadelphia. (AP)
Philadelphia Eagles stretch as they get ready during practice at NFL football training camp, Thursday, July 25, 2024, in Philadelphia. (AP)

For many people of a certain age, high school gym class began with reaching for their toes. Then, over the years, we were told it was better to stretch after exercise.

It turns out, both those things can be true, but the differing advice has created some confusion.

Stretching can help make you more flexible, improve range of motion in your joints — and feel good. David Behm, who researches human kinetics at Memorial University of Newfoundland in St. John’s, Canada, offers this advice on when to stretch and how to do it safely:

Warm up first

It’s almost always good to stretch, but it’s better if you warm up first, said Behm, author of "The Science and Physiology of Flexibility and Stretching." He recommends a light aerobic activity such as jogging, walking or cycling for five or 10 minutes.

Follow that with some static stretching, the traditional way of reaching and holding a position (think back to that gym class). You can then do activity-specific dynamic stretching, in which you warm up the muscles with repetitive movements like leg lifts.

Behm says one minute is "the magic number" for how long to do static stretching per muscle group without fatigue.

Expand your definition of 'stretching'

Should you always stretch before exercising? If it's traditional stretching, not necessarily.

The better question, Behm says, is, "Should people increase their range of motion? Should people have better flexibility? And that is yes, because it helps prevent injuries. It helps with health. But you don’t have to stretch to achieve that."

Resistance training, for instance, can be an effective form of stretching, he said. Doing a chest press increases range of motion in your deltoids and pecs, whether with barbells, dumbbells or machines, so there is no need to stretch beforehand. Just make sure to start with a small amount of weight to warm up and then add more to train.

"You probably don’t have to do extra stretching unless you’re a gymnast, a figure skater, or even a golfer who needs a great range of motion through that swing," Behm said.

Nor do you need to stretch first if you’re going for a leisurely run. Simply start with a slow jog to warm up and then increase the pace.

Don't do it if it hurts

After exercise, "light stretching is OK, as long as you don't reach a point where you're feeling pain," Behm said. Since your muscles will be warm by that point, overdoing it makes you more likely to injure yourself.

Foam rollers can help with muscle recovery and have been shown to increase range of motion as well as stretching.

Do some static stretching before sports

If you’re playing a sport, Behm said, static stretching beforehand helps reduce muscle and tendon injury.

"If you’re going to do an explosive movement, change of direction, agility, sprint, any of these explosive activities that involve your muscles and tendons," he said, "you’re going to be stronger if you do static stretching."

People can especially get in trouble when they go back to a sport they used to play, whether it's tennis, surfing or any sort of team activity.

Also, stretch both sides equally. Lacking flexibility on one side also can lead to injury.

Sounds simple. Why all the confusion? Different studies over the years have either encouraged or discouraged stretching before exercise. Behm says that partly because some studies didn't reflect real-life conditions, or were designed with elite athletes in mind, not regular people.

"If you’re Usain Bolt, it makes a difference," said Behm. Not so much for the rest of us.