Toxins of New Zealand Tree Could Help Produce Painkillers

Illustration photo shows various medicine pills in their original packaging in Brussels, Belgium August 9, 2019. REUTERS/Yves Herman/Illustration/File Photo
Illustration photo shows various medicine pills in their original packaging in Brussels, Belgium August 9, 2019. REUTERS/Yves Herman/Illustration/File Photo
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Toxins of New Zealand Tree Could Help Produce Painkillers

Illustration photo shows various medicine pills in their original packaging in Brussels, Belgium August 9, 2019. REUTERS/Yves Herman/Illustration/File Photo
Illustration photo shows various medicine pills in their original packaging in Brussels, Belgium August 9, 2019. REUTERS/Yves Herman/Illustration/File Photo

Researchers at The University of Queensland (UQ) have found that a native New Zealand stinging tree produces toxins that could hold clues for future pain medication. The findings were announced in the journal Biological Chemistry on July 27.

In a quest to find new molecules that affect pain pathways, Dr. Thomas Durek, Dr. Sam Robinson and a team from UQ's Institute for Molecular Bioscience (IMB) studied toxins from the tree nettle known as ongaonga, one of New Zealand's most poisonous plants that can cause painful stings that last for days, and in severe cases can even be fatal.

Dr. Robinson and a team from UQ previously investigated toxins found in an Australian gympie-gympie stinging tree but found the New Zealand tree nettle toxins activated pain receptors in a new way.

"We discovered that the New Zealand nettle tree toxins target the same receptor as their Australian counterparts, but they cause pain in a different way, " Robinson said in a report published on the university’s website.

The Australian stinging tree and New Zealand tree nettle are both members of the nettle family but separated millions of years ago and have evolved differently.

The New Zealand tree nettle can grow up to four meters tall and its leaves and stems are covered with stinging hairs that pierce the skin and deliver venom which causes long-lasting pain.

Fossil remains show that the large flightless bird, the Moa, had a liking for eating the tree nettle and it's likely the strong toxins evolved to fend off the now-extinct bird.

The team faced challenges during the study due to international COVID travel restrictions.

"COVID made it difficult to source nettles, but to keep our research going through the pandemic, we managed to source seeds from the New Zealand tree nettle and grow the plant under quarantine in the lab," Robinson said.

Professor Irina Vetter, director of IMB's Centre for Pain Research and co-author on the study, said understanding pain pathways was key to finding new ways to treat chronic pain



North Riyadh Geopark, Salma Geopark Join UNESCO’s Global Geoparks List

The newly recognized geoparks will serve as key destinations for local and international visitors, offering an opportunity to explore the Kingdom’s geological wonders while fostering scientific and cultural awareness of geodiversity conservation - SPA
The newly recognized geoparks will serve as key destinations for local and international visitors, offering an opportunity to explore the Kingdom’s geological wonders while fostering scientific and cultural awareness of geodiversity conservation - SPA
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North Riyadh Geopark, Salma Geopark Join UNESCO’s Global Geoparks List

The newly recognized geoparks will serve as key destinations for local and international visitors, offering an opportunity to explore the Kingdom’s geological wonders while fostering scientific and cultural awareness of geodiversity conservation - SPA
The newly recognized geoparks will serve as key destinations for local and international visitors, offering an opportunity to explore the Kingdom’s geological wonders while fostering scientific and cultural awareness of geodiversity conservation - SPA

The United Nations Educational, Scientific and Cultural Organization (UNESCO) has officially designated the North Riyadh Geopark and Salma Geopark as part of its UNESCO Global Geoparks Network, marking a significant milestone for Saudi Arabia in preserving geoheritage and promoting sustainable development.
The recognition follows UNESCO’s stringent selection criteria, which emphasize the comprehensive management of geoparks. These criteria ensure a balance between conservation, education, and sustainable development while actively involving local communities.
CEO of the National Center for Vegetation Cover Development and Combating Desertification (NCVC) Khaled Al-Abdulkader praised the announcement as a testament to Saudi Arabia’s dedication to protecting its natural and historical heritage, SPA reported.
He attributed the achievement to the steadfast support of the Saudi leadership in enhancing environmental initiatives and promoting sustainability.
He also underscored NCVC’s efforts to preserve the country’s unique natural landscapes, particularly its geological sites, in line with Vision 2030’s sustainable development goals.
Senior Director of the Saudi Geoparks Initiative Hussam Al-Turki emphasized that the inclusion of North Riyadh Geopark and Salma Geopark is a moment of national pride. He noted that this milestone not only reinforces Saudi Arabia’s commitment to preserving its cultural and natural identity but also strengthens its role as a global leader in geoheritage conservation and sustainable development.
With this designation, Saudi Arabia reaffirms its commitment to global environmental efforts.

According to SPA, the newly recognized geoparks will serve as key destinations for local and international visitors, offering an opportunity to explore the Kingdom’s geological wonders while fostering scientific and cultural awareness of geodiversity conservation.
Beyond geotourism, geoparks play a vital role in sustainable natural resource management by connecting geotourism with local economic development, creating jobs, and fostering environmental education. This initiative represents a collaborative effort among government bodies, the private sector, and non-profit organizations, enhancing Saudi Arabia’s contribution to both national and sustainable development goals.