FIFA President Gianni Infantino wrote to the presidents of the Palestinian and Israeli Football Federations on Friday calling for "the immediate end of hostilities".
Infantino offered "our deepest condolences to the Israel Football Association and the Palestine Football Association in light of the horrendous violence that has been occurring over the past days."
The letter was sent to Moshe Shino Zuares, head of Israel's FA and Jibril Rajoub, the president of the Palestinian FA.
"FIFA joins in calling for the immediate end of hostilities and the immediate relief of the suffering of the people of both Israel and Palestine," AFP quoted Infantino.
Infantino said football can be a "vehicle for peace."
"It is as heart-breaking as it is shocking to see a region, whose people have known such profound suffering over far too long, suffer even more.
"Of course, we know that football cannot solve the problems of the World, but it can play even a small part in bringing a light of hope where there appears to be only darkness ahead," Infantino wrote