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Scientists Create ‘Robotic Pill’ to Treat Osteoporosis

An illustration picture taken in Lille on May 7, 2017 shows pills, tablets, caplets and capsules of medicine. / AFP PHOTO / PHILIPPE HUGUEN
An illustration picture taken in Lille on May 7, 2017 shows pills, tablets, caplets and capsules of medicine. / AFP PHOTO / PHILIPPE HUGUEN
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Scientists Create ‘Robotic Pill’ to Treat Osteoporosis

An illustration picture taken in Lille on May 7, 2017 shows pills, tablets, caplets and capsules of medicine. / AFP PHOTO / PHILIPPE HUGUEN
An illustration picture taken in Lille on May 7, 2017 shows pills, tablets, caplets and capsules of medicine. / AFP PHOTO / PHILIPPE HUGUEN

A proven and effective medication for osteoporosis, which is currently only available as an injection, can be administered orally using a novel “robotic pill”, according to a study presented Saturday at ENDO 2023, the Endocrine Society's annual meeting in Chicago.

“We believe this study provides the first clinical evidence of safe and successful delivery of the osteoporosis drug teriparatide through an oral robotic pill,” said Arvinder Dhalla, who leads Clinical Development at Rani Therapeutics, the company that developed the technology. “Data from this study are very encouraging and should give hope to those suffering from chronic conditions that require painful injections, like osteoporosis,” she added.

When a person swallows the robotic pill, it moves through the stomach intact. In the intestine the pill releases a self-inflating balloon with a microsyringe, which injects a drug-filled microneedle and delivers the medication.

“The intestines do not have pain response to needles, so the injection is painless. The needle rapidly dissolves, and the medication is absorbed while the delivery mechanism deflates and is safely passed out of the body,” Dhalla explained.

“The robotic pill, which is essentially a swallowable auto-injector in the form of a pill, is designed to deliver the drug safely and efficiently as a painless intestinal injection,” she said.

The study of 39 healthy women evaluated the safety, tolerability and movement through the body of the robotic pill known as RT-102, containing a dose of the drug teriparatide (PTH 1-34).

Teriparatide is a synthetic form of the natural human parathyroid hormone. It has been in clinical use for decades as an injectable medication (under the brand name Forteo) for rebuilding brittle bones of osteoporosis patients. It is taken as a daily injection for up to two years.

Study participants were divided into three groups. Two groups received either a lower or higher dose delivered with the robotic pill, and the third group received a standard injection of teriparatide. Fluoroscopic imaging was used to track the robotic pill through and out the body. Drug concentrations were measured in blood samples collected over six hours.

The study found the bioavailability (the ability of the drug to be absorbed and used by the body) of the drug delivered by the robotic pill was comparable to or better than the drug given via the injection.

“This breakthrough technology of converting injections into oral pills is a significant step forward towards ending the burden of painful injections for millions of patients suffering from chronic diseases,” Dhalla concluded.

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Water Levels Plummet at Drought-Hit Iraqi Reservoir

Kochar Jamal Tawfeeq, director of the Dukan Dam facility, gives an interview by the reservoir northwest of Iraq's northeastern city of Sulaimaniyah in the autonomous Kurdistan region on June 4, 2025, where waters have been receding due to a mix of factors including lower rainfall, severe drought, and diversion of inflowing rivers from Iran. (AFP)
Kochar Jamal Tawfeeq, director of the Dukan Dam facility, gives an interview by the reservoir northwest of Iraq's northeastern city of Sulaimaniyah in the autonomous Kurdistan region on June 4, 2025, where waters have been receding due to a mix of factors including lower rainfall, severe drought, and diversion of inflowing rivers from Iran. (AFP)
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Water Levels Plummet at Drought-Hit Iraqi Reservoir

Kochar Jamal Tawfeeq, director of the Dukan Dam facility, gives an interview by the reservoir northwest of Iraq's northeastern city of Sulaimaniyah in the autonomous Kurdistan region on June 4, 2025, where waters have been receding due to a mix of factors including lower rainfall, severe drought, and diversion of inflowing rivers from Iran. (AFP)
Kochar Jamal Tawfeeq, director of the Dukan Dam facility, gives an interview by the reservoir northwest of Iraq's northeastern city of Sulaimaniyah in the autonomous Kurdistan region on June 4, 2025, where waters have been receding due to a mix of factors including lower rainfall, severe drought, and diversion of inflowing rivers from Iran. (AFP)

Water levels at Iraq's vast Dukan Dam reservoir have plummeted as a result of dwindling rains and further damming upstream, hitting millions of inhabitants already impacted by drought with stricter water rationing.

Amid these conditions, visible cracks have emerged in the retreating shoreline of the artificial lake, which lies in northern Iraq's autonomous Kurdistan region and was created in the 1950s.

Dukan Lake has been left three quarters empty, with its director Kochar Jamal Tawfeeq explaining its reserves currently stand at around 1.6 billion cubic meters of water out of a possible seven billion.

That is "about 24 percent" of its capacity, the official said, adding that the level of water in the lake had not been so low in roughly 20 years.

Satellite imagery analyzed by AFP shows the lake's surface area shrank by 56 percent between the end of May 2019, the last year it was completely full, and the beginning of June 2025.

Tawfeeq blamed climate change and a "shortage of rainfall" explaining that the timing of the rains had also become irregular.

Over the winter season, Tawfeeq said the Dukan region received 220 millimeters (8.7 inches) of rain, compared to a typical 600 millimeters.

- 'Harvest failed' -

Upstream damming of the Little Zab River, which flows through Iran and feeds Dukan, was a secondary cause of the falling water levels, Tawfeeq explained.

Also buffeted by drought, Iran has built dozens of structures on the river to increase its own water reserves.

Baghdad has criticized these kinds of dams, built both by Iran and neighboring Türkiye, accusing them of significantly restricting water flow into Iraq via the Tigris and Euphrates rivers.

Iraq, and its 46 million inhabitants, have been intensely impacted by the effects of climate change, experiencing rising temperatures, year-on-year droughts and rampant desertification.

At the end of May, the country's total water reserves were at their lowest level in 80 years.

On the slopes above Dukan lies the village of Sarsian, where Hussein Khader Sheikhah, 57, was planting a summer crop on a hectare of land.

The farmer said he hoped a short-term summer crop of the kind typically planted in the area for an autumn harvest -- cucumbers, melons, chickpeas, sunflower seeds and beans -- would help him offset some of the losses over the winter caused by drought.

In winter, in another area near the village, he planted 13 hectares mainly of wheat.

"The harvest failed because of the lack of rain," he explained, adding that he lost an equivalent of almost $5,700 to the poor yield.

"I can't make up for the loss of 13 hectares with just one hectare near the river," he added.

- 'Stricter rationing' -

The water shortage at Dukan has affected around four million people downstream in the neighboring Sulaimaniyah and Kirkuk governorates, including their access to drinking water.

For more than a month, water treatment plants in Kirkuk have been trying to mitigate a sudden, 40 percent drop in the supplies reaching them, according to local water resource official Zaki Karim.

In a country ravaged by decades of conflict, with crumbling infrastructure and floundering public policies, residents already receive water intermittently.

The latest shortages are forcing even "stricter rationing" and more infrequent water distributions, Karim said.

In addition to going door-to-door to raise awareness about water waste, the authorities were also cracking down on illegal access to the water network.

In the province of roughly two million inhabitants, the aim is to minimize the impact on the provincial capital of Kirkuk.

"If some treatment plants experience supply difficulties, we will ensure that there are no total interruptions, so everyone can receive their share," Karim said.