Syria's Ancient Adobe Houses Threatened by War, Displacement

The village once had more than 3,000 residents but, after fighting raged there, 'everyone left', says a local man - AFP
The village once had more than 3,000 residents but, after fighting raged there, 'everyone left', says a local man - AFP
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Syria's Ancient Adobe Houses Threatened by War, Displacement

The village once had more than 3,000 residents but, after fighting raged there, 'everyone left', says a local man - AFP
The village once had more than 3,000 residents but, after fighting raged there, 'everyone left', says a local man - AFP

Traditional mud-brick houses that the people of northern Syria have built for thousands of years risk disappearing, as 12 years of war have emptied villages and left the buildings crumbling.

Also knowns as "beehive houses", the conical adobe structures are designed to keep cool in the blazing desert sun, while their thick walls also retain warmth in the winter.

Umm Amuda Kabira village in Aleppo province is among a handful of places where residents long used to live in the small domed houses, made of mud mixed with brittle hay.

"Our village once had 3,000 to 3,500 residents and some 200 mud houses," said Mahmud al-Mheilej, standing beside deserted homes with weeds growing out of the roofs.

"Everyone left" after the region saw heavy fighting and was overrun by Islamic State group jihadists, the schoolteacher in his 50s told AFP.

Aleppo province was the scene of fierce battles between Syrian government forces, opposition and ISIS extremists from 2012 until Russian-backed government forces gradually ousted them.

While the violence has waned in the area, instability and economic hardship have long become a fact of life across Syria.

"No more than 200 of us have returned" to the village, said Mheilej, who now lives in a concrete building close by.

Inside one traditional house, crevasses snaked along white walls riddled with holes.

All of the mud-brick homes have been abandoned, Mheilej said, pointing at a tumbledown wall, the remnants of a collapsed house.

"There is no one left to take care of the houses, that's why they are decaying," he added. "In time, they will disappear without a trace."

Syria's war broke out in 2011 and quickly escalated into a conflict that pulled in foreign powers and militants.

The fighting has killed more than 500,000 people, and millions have been displaced.

"We were born and raised inside the mud houses," said Jamal al-Ali, 66, from outside the ancestral home his family was forced to abandon in nearby Haqla.

The domed structure kept inhabitants cool in the summer and warm in the winter, said Ali, as he shared a meal with his family on a straw carpet.

Local masons were among those who fled the fighting, leaving the region short of their ancestral know-how.

Issa Khodr, 58, who took refuge in neighbouring Lebanon, is one of the last Syrians with expertise in building the structures, which require regular upkeep.

With support from local charity Arcenciel, he has recreated the rustic dwellings in the Bekaa Valley, home to a large Syrian refugee population.

"I learnt the trade in the village when I was 14 because every time someone wanted to build a mud house, others would help," said the former civil servant.

"Because of the war, the houses are disappearing, and so is our profession," said Khodr.

Lebanese architect Fadlallah Dagher said the construction technique "is believed to have originated during the Neolithic period some 8,000 years ago".

The project aims to pass on knowledge among the refugees, Dagher said, so that "once they return to their devastated country, which lacks resources, they can build their own homes".



Innovative Drug Lowers Triglycerides, Other Blood Lipids

High levels of triglycerides in the blood increase the risk of heart disease (Monash University) 
High levels of triglycerides in the blood increase the risk of heart disease (Monash University) 
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Innovative Drug Lowers Triglycerides, Other Blood Lipids

High levels of triglycerides in the blood increase the risk of heart disease (Monash University) 
High levels of triglycerides in the blood increase the risk of heart disease (Monash University) 

A study led by researchers from the Ecole Polytechnique Fédérale de Lausanne (EPFL) in Switzerland, revealed a new liver- and gut-targeted oral drug that can safely lower triglycerides and other blood lipids.

Researchers of the study, published last Friday in Nature Medicine, said the innovative drug could represent a breakthrough in treating metabolic diseases related to high triglycerides in the body.

The study said that when we eat, our bodies convert extra calories, especially from carbs, sugar, fats, and alcohol, into molecules called “triglycerides.”

Triglycerides are a form of fat or “lipid,” which the body stores away into its fat cells as an energy fuel for energy between meals.

But, excess amounts of fat in the body can be dangerous, causing a condition known as “hypertriglyceridemia” (“excess triglycerides in the blood”), which significantly increases the risk of heart disease, stroke, and pancreatitis.

This is why we are universally advised to make healthy lifestyle choices in diet, exercise, while particularly bad cases require medication.

The study also found that keeping blood fats in check depends on a careful balance.

It said the liver and intestine release fat particles into the bloodstream, while enzymes work to break them down and clear them away.

When fat production outpaces clearance, triglycerides build up, setting the stage for metabolic diseases like dyslipidemia, acute pancreatitis, and metabolic dysfunction-associated steatotic liver disease (MASLD).

One of the master switches in this system is a protein called Liver X Receptor, or LXR, which controls several genes that are involved in making and handling fats.

When LXR is active, triglycerides and cholesterol tend to rise.

Therefore, dialing it down through medication seems promising, but as LXR is also involved in protective cholesterol pathways elsewhere in the body, blocking it everywhere could do more harm than good.

Now, scientists have addressed this problem with an orally administered compound that can repress the activity of LXR specifically in the liver and gut to lower triglycerides without disrupting the body’s protective cholesterol pathways.

The compound, TLC‑2716, is what is known as an “inverse agonist” for the LXR. Unlike a “blocker” (“antagonist”) that merely stops a receptor from being activated, an “inverse agonist” makes the receptor signal the opposite effect to what it would normally do.

Clinical Trial

The lab findings set the stage for a randomized, placebo-controlled Phase 1 study in healthy adults. Participants received TLC‑2716 for 14 days given as a single dose per day and the trial focused first on safety and tolerability, and the authors report that the drug met these primary endpoints.

But even this short trial had clear effects: participants who received higher doses of TLC‑2716 showed notable drops in triglycerides as well as remnant cholesterol.

At the highest doses of TLC‑2716 (12mg), triglycerides fell by up to 38.5%, while postprandial (“after eating”) remnant cholesterol dropped by as much as 61%.

This happened despite participants starting with relatively normal lipid levels and without the use of other lipid-lowering drugs, the study showed.

Also, the treatment sped up triglyceride clearance by reducing the activity of two proteins that normally slow it down, ApoC3 and ANGPTL3.

At the same time, the study did not detect reductions in blood-cell expression of ABCA1 and ABCG1, genes used here as markers linked to reverse cholesterol transport.

Researchers said larger trials will be needed, but, for now, the concept has its first human proof of principle.


Small Part of Sunshine State Becomes Snowy State as Florida Gets Snow Second Year in a Row

A rare snow is seen in Holt, Florida, on Sunday, Jan. 18, 2026. (Danielle Brahier via AP)
A rare snow is seen in Holt, Florida, on Sunday, Jan. 18, 2026. (Danielle Brahier via AP)
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Small Part of Sunshine State Becomes Snowy State as Florida Gets Snow Second Year in a Row

A rare snow is seen in Holt, Florida, on Sunday, Jan. 18, 2026. (Danielle Brahier via AP)
A rare snow is seen in Holt, Florida, on Sunday, Jan. 18, 2026. (Danielle Brahier via AP)

A small part of Florida is the Snowy State for the second year in a row.

Snow briefly covered the grass and rooftops in parts of the western Florida Panhandle on Sunday morning as just enough frigid air rushed in behind a cold front to turn the last rain showers into snowflakes in the Sunshine State.

And it wasn't a once-in-a-lifetime thing. Less than a year ago, on Jan. 21, 2025, some of those same areas saw up to 8 inches (20 centimeters) of snow in what was the most significant snowfall in many places since the late 1800s.

Snow photos flooded social media. There were a few flakes on the beach and snow nestled into palm fronds. It was too warm to stick to the roads, but a dusting of snow sat on the grass for a little while before mostly melting.

The rare snow in the South wasn't just in Florida. Southeastern Alabama and southern Georgia also reported snow in areas that also got to celebrate a second winter wonderland in less than a year.

Snow covered the ground in Columbus and Macon, Georgia, and officials warned enough might fall to make travel treacherous.


Shark Mauls Boy in Sydney Harbor

 This photo shows an aerial view of Bondi Beach and Sydney Harbor as seen from a plane flying over Sydney on January 14, 2026. (AFP)
This photo shows an aerial view of Bondi Beach and Sydney Harbor as seen from a plane flying over Sydney on January 14, 2026. (AFP)
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Shark Mauls Boy in Sydney Harbor

 This photo shows an aerial view of Bondi Beach and Sydney Harbor as seen from a plane flying over Sydney on January 14, 2026. (AFP)
This photo shows an aerial view of Bondi Beach and Sydney Harbor as seen from a plane flying over Sydney on January 14, 2026. (AFP)

A shark mauled a boy swimming in Sydney Harbor on Sunday, leaving him in critical condition with serious leg injuries, authorities said.

The predator bit the boy, believed to be about 13 years old, during the late afternoon off Shark Beach, New South Wales state police said.

"The injuries are consistent with what is believed to have been a large shark," police said in a statement.

Officers pulled the boy from the water off the harbor beach within minutes of being alerted to the incident, police said.

They gave the boy first aid for "serious" leg injuries while he was aboard a police boat, applying two medical tourniquets.

Paramedics transported him to Sydney Children's Hospital, where he was said to be in critical condition.

"Swimmers are advised to avoid entering nearby waters at this time," police said.

Shark Beach, in Sydney's eastern suburb of Vaucluse, was closed and police evacuated nearby beaches in the harbor, the state government said.

Wildlife experts were working to identify the shark species involved, it said in a statement.

"This is a tragic shark attack on a young boy having a swim on a Sunday afternoon near a harbor beach in Sydney's east," New South Wales Agriculture Minister Tara Moriarty said.

"Our thoughts are with the young boy and his family. I understand there were also other young people with him at the time of the attack, our thoughts are also with them."

There have been more than 1,280 shark incidents around Australia since 1791, of which more than 250 resulted in death, according to a database of the predators' encounters with humans.

Increasingly crowded waters and rising ocean temperatures that appear to be swaying sharks' migratory patterns may be contributing to a rise in attacks despite overfishing depleting some species, scientists say.

A great white shark mauled surfer Mercury Psillakis to death at a popular northern Sydney ocean beach in September.

Two months later, a bull shark killed a woman swimming off a remote beach north of Sydney.