Drug Protects Kidneys, Heart in Diabetic Patients

This Jan. 3, 2009, file photo shows a person with diabetes testing his blood sugar level in Kamen, Germany. (AP)
This Jan. 3, 2009, file photo shows a person with diabetes testing his blood sugar level in Kamen, Germany. (AP)
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Drug Protects Kidneys, Heart in Diabetic Patients

This Jan. 3, 2009, file photo shows a person with diabetes testing his blood sugar level in Kamen, Germany. (AP)
This Jan. 3, 2009, file photo shows a person with diabetes testing his blood sugar level in Kamen, Germany. (AP)

A recent Canadian study has found that a drug prescribed to treat heart failure could protect kidney and heart health in individuals with type 2 diabetes and chronic kidney disease.

Results from the study were presented on November 4, at ASN Kidney Week 2023 organized by the American Society of Nephrology, in Philadelphia.

The study of a drug named “Sotagliflozin”, which has been approved by the FDA in May as a heart failure treatment, also involved non-diabetic patients.

Sotagliflozin is a Sodium-glucose cotransporter-2 (SGLT2) inhibitor, which lowers blood sugar by inhibiting glucose absorption in the kidneys, and can also be used to treat type 2 diabetes.

Researchers have found that these drugs provide kidney- and heart-related benefits to patients with and without diabetes.

During the study, the research team observed 10,584 patients with type 2 diabetes, chronic kidney disease and cardiovascular factors to receive sotagliflozin or placebo.

Over a median follow-up of 16 months, the researchers found sotagliflozin reduced the risk of glomerular filtration by 50 percent, and dialysis or kidney transplant by 38 percent.

They also found that compared to placebo, sotagliflozin reduced the risk of heart and kidney problems, as well as cardiovascular diseases-related deaths by 23 percent.

“These effects add to the already reported benefits of sotagliflozin in reducing both heart failure and ischemic events such as myocardial infarction or stroke,” said corresponding author David Cherney of the University of Toronto.

“Sotagliflozin is now FDA approved to reduce the risk of cardiovascular death and heart failure events with a broad label that includes patients with heart failure or chronic kidney disease, so the drug is now an option for nephrologists and cardiologists, as well as primary care physicians, to prescribe,” he told the York Alert website.



Cities Around the World Welcome 2026 with Fireworks and Heightened Security

Fireworks are seen over Sydney Harbour during the New Year's Eve midnight display, at Mrs Macquaries Point in Sydney, 01 January 2026. EPA/DAN HIMBRECHTS
Fireworks are seen over Sydney Harbour during the New Year's Eve midnight display, at Mrs Macquaries Point in Sydney, 01 January 2026. EPA/DAN HIMBRECHTS
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Cities Around the World Welcome 2026 with Fireworks and Heightened Security

Fireworks are seen over Sydney Harbour during the New Year's Eve midnight display, at Mrs Macquaries Point in Sydney, 01 January 2026. EPA/DAN HIMBRECHTS
Fireworks are seen over Sydney Harbour during the New Year's Eve midnight display, at Mrs Macquaries Point in Sydney, 01 January 2026. EPA/DAN HIMBRECHTS

From Sydney to Paris to New York City, crowds rang in the new year with exuberant celebrations filled with thunderous fireworks or light shows, while others took a more subdued approach.

As the clock struck midnight in Japan, temple bells rang and some climbed mountains to see the year’s first sunrise, while a light show with somersaulting jet skis twinkled in Dubai. The countdown to 2026 was projected onto the Arc de Triomphe in Paris, while in Moscow people celebrated in the snow, The Associated Press reported.

In New York City's Times Square, revelers braved frigid temperatures to celebrate with the famed New Year’s Eve ball drop.

In Rio de Janeiro, crowds packed more than 4 kilometers (2 1/2 miles) of the city’s Copacabana Beach for concerts and a 12-minute fireworks show, despite high tides and large waves that rocked barges carrying fireworks.

Other events were more subdued. Hong Kong held limited celebrations following a recent fire at an apartment complex that killed 161 people.

Australia saluted the new year with defiance less than a month after its worst mass shooting in almost 30 years.

Crowds bundled up against the chilly temperatures cheered and embraced as the New Year’s Eve ball covered in more than 5,000 crystals descended down a pole and confetti fell in Times Square.

Revelers wearing tall celebratory hats and light-up necklaces had waited for hours to see the 12,350-pound (5,602-kilograms) ball drop. The festivities also included Tones and I performing John Lennon's “Imagine” just before midnight.

The television hosts interviewed visitors who were attending from such places as Florida, Mexico and South Korea, and read people's wishes for the new year.

A sixth grader from Dallas, Texas, told one of the hosts that he wants to get good grades in 2026 and have a better year.

Police in the city had planned additional anti-terrorism measures at the ball drop, with “mobile screening teams.” It was not in response to a specific threat, according to NYPD Commissioner Jessica Tisch.

Moments after the ball dropped it rose again, sparkling in red, white and blue, to mark the country’s upcoming 250th birthday.

A few miles away in a decommissioned subway station, Zohran Mamdani was sworn in as mayor during a private event just after midnight Thursday.

A heavy police presence monitored crowds watching fireworks in Sydney.

Many officers openly carried rapid-fire rifles, a first for the event, after two gunmen targeted a Hannukah celebration at Bondi Beach on Dec. 14, killing 15.

An hour before midnight, victims were commemorated with a minute of silence, and the crowd was invited to show solidarity with Australia’s Jewish community.

New South Wales Premier Chris Minns had urged residents not to stay away from festivities, saying extremists would interpret smaller crowds as a victory: “We have to show defiance in the face of this terrible crime."

Indonesia scaled back festivities in solidarity with communities devastated by floods and landslides in parts of Sumatra a month ago that killed over 1,100. Fireworks on the tourist island of Bali were replaced with traditional dances.

Hong Kong rang in 2026 without fireworks over Victoria Harbor after the massive fire in November. Facades of landmarks were turned into countdown clocks and a light show at midnight.

And in Gaza, Palestinians said they hope the new year brings an end to the conflict between Israel and Hamas.

“The war humiliated us,” said Mirvat Abed Al-Aal, displaced from the southern city of Rafah.

Around Europe Pope Leo XIV closed out the year with a plea for the city of Rome to welcome foreigners and the fragile. Fireworks erupted over European landmarks, from the Colosseum in Rome to the London Eye.

In Paris, revelers converged around the glittering Champs-Élysées avenue. Taissiya Girda, a 27-year-old tourist from Kazakhstan, expressed hope for a calmer 2026.

“I would like to see happy people around me, no war anywhere,” she said.

“Russia, Ukraine, Palestine, Israel, I want everybody to be happy and in peace."

In Scotland, where New Year’s is known as Hogmanay, First Minister John Swinney urged Scots to follow the message of “Auld Lang Syne” by national poet Robert Burns and show small acts of kindness.

Greece and Cyprus turned down the volume, replacing traditional fireworks with low-noise pyrotechnics in capitals. Officials said the change was intended to make celebrations more welcoming for children and pets.


Heavy Snow in Poland Leaves Drivers Stranded in Tailbacks of up to 20 Km

Cars drive on a road during heavy snowfall in central Warsaw, Poland, 30 December 2025. (EPA)
Cars drive on a road during heavy snowfall in central Warsaw, Poland, 30 December 2025. (EPA)
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Heavy Snow in Poland Leaves Drivers Stranded in Tailbacks of up to 20 Km

Cars drive on a road during heavy snowfall in central Warsaw, Poland, 30 December 2025. (EPA)
Cars drive on a road during heavy snowfall in central Warsaw, Poland, 30 December 2025. (EPA)

Heavy snowfall in Poland caused tailbacks stretching as far as 20 km (12.43 miles) on a motorway between ​the capital Warsaw and the Baltic port city of Gdansk during the night, police said on Wednesday.

While the situation left hundreds of people trapped in their cars in freezing conditions, by the early hours of ‌Wednesday morning traffic ‌was moving again, ‌according ⁠to ​police.

"The ‌difficult situation began yesterday after 4 p.m., when the first trucks on the S7 route... began having trouble approaching the slopes," said Tomasz Markowski, a spokesperson for police in the northern city of ⁠Olsztyn.

"This led to a traffic jam stretching approximately ‌20 kilometers overnight." Deputy Infrastructure Minister ‍Stanislaw Bukowiec ‍told a press conference that nobody had ‍been hurt as a result of the difficult situation on the roads.

Anna Karczewska, a spokesperson for police in Ostroda, said officers had ​tried to help drivers who found themselves stuck. Ostroda lies on ⁠the highway about 40 km west of Olsztyn.

"We helped as much as we could, and we had coffee and hot tea for the drivers, which the Ostroda City Hall had prepared for us," she said.

State news agency PAP reported that there had also been some disruption to railways and airports, ‌but that services were returning to normal.


Infant Screen Exposure Shapes Long-Term Brain Changes and Teen Anxiety, Study Finds  

The study concluded that children exposed to high levels of screen time before age two are exposed to endure adolescent mental health. (The University of Queensland)
The study concluded that children exposed to high levels of screen time before age two are exposed to endure adolescent mental health. (The University of Queensland)
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Infant Screen Exposure Shapes Long-Term Brain Changes and Teen Anxiety, Study Finds  

The study concluded that children exposed to high levels of screen time before age two are exposed to endure adolescent mental health. (The University of Queensland)
The study concluded that children exposed to high levels of screen time before age two are exposed to endure adolescent mental health. (The University of Queensland)

Children exposed to high levels of screen time before age two showed changes in brain development that were linked to slower decision-making and increased anxiety by their teenage years, according to new study released by the Agency for Science, Technology and Research in Singapore.

Prepared in collaboration with the National University of Singapore (NUS) Yong Loo Lin School of Medicine, the study focuses on infancy, a period when brain development is most rapid and especially sensitive to environmental influences.

The amount and type of screen exposure in infancy are largely determined by parental and caregiver awareness and parenting practices, highlighting a critical window for early guidance and intervention, showed the study, published in eBioMedicine on Tuesday.

It said the researchers followed 168 children before age two and conducted brain scans at three time points (ages 4.5, 6, and 7.5), which allowed them to track how brain networks developed over time rather than relying on a single snapshot.

Children with higher infant screen time showed an accelerated maturation of brain networks responsible for visual processing and cognitive control.

The researchers suggest this may result from the intense sensory stimulation that screens provide. Notably, screen time measured at ages three and four did not show the same effects, underscoring why infancy is a particularly sensitive period.

The study showed that children with high screen exposure, the networks controlling vision and cognition specialized faster, before they had developed the efficient connections needed for complex thinking. This can limit flexibility and resilience, leaving the child less able to adapt later in life.

It said this premature specialization came at a cost: children with these altered brain networks took longer to make decisions during a cognitive task at age 8.5, suggesting reduced cognitive efficiency or flexibility.

Those with slower decision-making, in turn, reported higher anxiety symptoms at age 13. These findings suggest that screen exposure in infancy may have effects that extend well beyond early childhood, shaping brain development and behavior years later.

In a related study, the same team found that infant screen time is also associated with alterations in brain networks that govern emotional regulation — but that parent-child reading could counteract some of these brain changes.

Researchers found that their results give a biological explanation for why limiting screen time in the first two years is crucial.

“But it also highlights the importance of parental engagement, showing that parent-child activities, like reading together, can make a real difference,” said Asst Prof Tan Ai Peng, Clinician-Scientist at NUS, and the study's senior author.

The study concluded that children exposed to high levels of screen time before age two are exposed to endure adolescent mental health, particularly on cognitive performance and anxiety levels.