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Drug Protects Kidneys, Heart in Diabetic Patients

This Jan. 3, 2009, file photo shows a person with diabetes testing his blood sugar level in Kamen, Germany. (AP)
This Jan. 3, 2009, file photo shows a person with diabetes testing his blood sugar level in Kamen, Germany. (AP)
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Drug Protects Kidneys, Heart in Diabetic Patients

This Jan. 3, 2009, file photo shows a person with diabetes testing his blood sugar level in Kamen, Germany. (AP)
This Jan. 3, 2009, file photo shows a person with diabetes testing his blood sugar level in Kamen, Germany. (AP)

A recent Canadian study has found that a drug prescribed to treat heart failure could protect kidney and heart health in individuals with type 2 diabetes and chronic kidney disease.

Results from the study were presented on November 4, at ASN Kidney Week 2023 organized by the American Society of Nephrology, in Philadelphia.

The study of a drug named “Sotagliflozin”, which has been approved by the FDA in May as a heart failure treatment, also involved non-diabetic patients.

Sotagliflozin is a Sodium-glucose cotransporter-2 (SGLT2) inhibitor, which lowers blood sugar by inhibiting glucose absorption in the kidneys, and can also be used to treat type 2 diabetes.

Researchers have found that these drugs provide kidney- and heart-related benefits to patients with and without diabetes.

During the study, the research team observed 10,584 patients with type 2 diabetes, chronic kidney disease and cardiovascular factors to receive sotagliflozin or placebo.

Over a median follow-up of 16 months, the researchers found sotagliflozin reduced the risk of glomerular filtration by 50 percent, and dialysis or kidney transplant by 38 percent.

They also found that compared to placebo, sotagliflozin reduced the risk of heart and kidney problems, as well as cardiovascular diseases-related deaths by 23 percent.

“These effects add to the already reported benefits of sotagliflozin in reducing both heart failure and ischemic events such as myocardial infarction or stroke,” said corresponding author David Cherney of the University of Toronto.

“Sotagliflozin is now FDA approved to reduce the risk of cardiovascular death and heart failure events with a broad label that includes patients with heart failure or chronic kidney disease, so the drug is now an option for nephrologists and cardiologists, as well as primary care physicians, to prescribe,” he told the York Alert website.

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1st Car Made during Soviet-era in Poland Goes on Display 73 Years Later

This Warszawa M-20 car with serial number 000001, based on a Soviet Union's model, was the first vehicle to leave a car factory in Poland after World War II, on Nov. 6, 1951 and now, 73 years later, it goes on public display at a private museum in Otrebusy, central Poland, on Wednesday, Nov. 6, 2024. (AP Photo/Czarek Sokolowski)
This Warszawa M-20 car with serial number 000001, based on a Soviet Union's model, was the first vehicle to leave a car factory in Poland after World War II, on Nov. 6, 1951 and now, 73 years later, it goes on public display at a private museum in Otrebusy, central Poland, on Wednesday, Nov. 6, 2024. (AP Photo/Czarek Sokolowski)
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1st Car Made during Soviet-era in Poland Goes on Display 73 Years Later

This Warszawa M-20 car with serial number 000001, based on a Soviet Union's model, was the first vehicle to leave a car factory in Poland after World War II, on Nov. 6, 1951 and now, 73 years later, it goes on public display at a private museum in Otrebusy, central Poland, on Wednesday, Nov. 6, 2024. (AP Photo/Czarek Sokolowski)
This Warszawa M-20 car with serial number 000001, based on a Soviet Union's model, was the first vehicle to leave a car factory in Poland after World War II, on Nov. 6, 1951 and now, 73 years later, it goes on public display at a private museum in Otrebusy, central Poland, on Wednesday, Nov. 6, 2024. (AP Photo/Czarek Sokolowski)

The very first car produced in Soviet-era Poland after World War II went on display Friday near Warsaw after it was tracked down in Finland during decades of searching and acquired after years of negotiations.

The chunky 1951 Warszawa M-20 bears the serial number 000001 it had when it left the FSO Passenger Car Factory in Warsaw on Nov. 6 of that year, exactly 73 years ago. It is a relic of the period of Poland’s post-war subordination to communist-ruled Soviet Union.

“We are extremely proud because now we count among the very few people in the world who have retrieved the very first vehicles of the series made in their countries,” said Zbigniew Mikiciuk, a co-founder of the private museum in Otrebusy.

The car was first given to the Soviet army marshal Konstantin Rokossovsky, who served as Poland’s defense minister after the war to seal the country’s dependency to Moscow. It eventually was discovered in the possession of the family of Finnish rally car driver Rauno Aaltonen, though the car's history in between remains unclear, Mikiciuk said.
It took more than two years of negotiations to obtain the vehicle from the Finnish owners, The Associated Press quoted him as saying.

The car's original light color has been painted over with a shade of brown that was fashionable in the 1970s and bears marks of once-intensive use that the museum has preserved to keep it authentic, but it is still "holding together” and is “cool” despite its age, Mikiciuk said.
The now-defunct FSO factory intensively sought the original model during the 1970s in hopes of using it to mark an anniversary. The company even offered a new car in exchange for it, at a time when cars were still a luxury in Poland, but to no avail.
The FSO factory was originally built in the late 1940s to make Italian Fiat 508 and 1100 cars, but Soviet leaders in Moscow objected to the ties with a Western company during the Cold War. They ordered production to be based on the Soviet Union's Pobeda (Victory) cars, with Moscow providing the technology and the production lines.
The car now joins the museum’s many historic vehicles, including a 1928 US-made Oakland brought to Poland before the war by a doctor’s family and a 1953 Buick that belonged to Poland’s communist-era Prime Minister Jozef Cyrankiewicz. The former leader brought the car to Poland via the Netherlands apparently to avoid a direct connection to the US during the Cold War.
The museum also displays a Volvo that was used by Poland’s communist leader, Gen. Wojciech Jaruzelski, known for having imposed martial law in 1981.
“We have been doing this for more than 50 years and we are not collecting cars you can see in the street but cars that have their history, their soul and their legend,” Mikiciuk said.
The museum owners hope that by displaying the initial Warszawa M-20 they can encourage members of the public to come forward and fill in more details of its history.