Drug Protects Kidneys, Heart in Diabetic Patients

This Jan. 3, 2009, file photo shows a person with diabetes testing his blood sugar level in Kamen, Germany. (AP)
This Jan. 3, 2009, file photo shows a person with diabetes testing his blood sugar level in Kamen, Germany. (AP)
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Drug Protects Kidneys, Heart in Diabetic Patients

This Jan. 3, 2009, file photo shows a person with diabetes testing his blood sugar level in Kamen, Germany. (AP)
This Jan. 3, 2009, file photo shows a person with diabetes testing his blood sugar level in Kamen, Germany. (AP)

A recent Canadian study has found that a drug prescribed to treat heart failure could protect kidney and heart health in individuals with type 2 diabetes and chronic kidney disease.

Results from the study were presented on November 4, at ASN Kidney Week 2023 organized by the American Society of Nephrology, in Philadelphia.

The study of a drug named “Sotagliflozin”, which has been approved by the FDA in May as a heart failure treatment, also involved non-diabetic patients.

Sotagliflozin is a Sodium-glucose cotransporter-2 (SGLT2) inhibitor, which lowers blood sugar by inhibiting glucose absorption in the kidneys, and can also be used to treat type 2 diabetes.

Researchers have found that these drugs provide kidney- and heart-related benefits to patients with and without diabetes.

During the study, the research team observed 10,584 patients with type 2 diabetes, chronic kidney disease and cardiovascular factors to receive sotagliflozin or placebo.

Over a median follow-up of 16 months, the researchers found sotagliflozin reduced the risk of glomerular filtration by 50 percent, and dialysis or kidney transplant by 38 percent.

They also found that compared to placebo, sotagliflozin reduced the risk of heart and kidney problems, as well as cardiovascular diseases-related deaths by 23 percent.

“These effects add to the already reported benefits of sotagliflozin in reducing both heart failure and ischemic events such as myocardial infarction or stroke,” said corresponding author David Cherney of the University of Toronto.

“Sotagliflozin is now FDA approved to reduce the risk of cardiovascular death and heart failure events with a broad label that includes patients with heart failure or chronic kidney disease, so the drug is now an option for nephrologists and cardiologists, as well as primary care physicians, to prescribe,” he told the York Alert website.



Tunisia Women Herb Harvesters Struggle with Drought and Heat

A woman harvests aromatic and medicinal plants in the mountains of Tbainia village near the city of Ain Drahem, in the northwest of Tunisia on November 6, 2024. (AFP)
A woman harvests aromatic and medicinal plants in the mountains of Tbainia village near the city of Ain Drahem, in the northwest of Tunisia on November 6, 2024. (AFP)
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Tunisia Women Herb Harvesters Struggle with Drought and Heat

A woman harvests aromatic and medicinal plants in the mountains of Tbainia village near the city of Ain Drahem, in the northwest of Tunisia on November 6, 2024. (AFP)
A woman harvests aromatic and medicinal plants in the mountains of Tbainia village near the city of Ain Drahem, in the northwest of Tunisia on November 6, 2024. (AFP)

On a hillside in Tunisia's northwestern highlands, women scour a sun-scorched field for the wild herbs they rely on for their livelihoods, but droughts and rising temperatures are making it ever harder to find the precious plants.

Yet the harvesters say they have little choice but to struggle on, as there are few opportunities in a country hit hard by unemployment, inflation and high living costs.

"There is a huge difference between the situation in the past and what we are living now," said Mabrouka Athimni, who heads a local collective of women herb harvesters named "Al Baraka" ("Blessing").

"We're earning half, sometimes just a third, of what we used to."

Tunisia produces around 10,000 tons of aromatic and medicinal herbs each year, according to official figures.

Rosemary accounts for more than 40 percent of essential oil exports, mainly destined for French and American markets.

For the past 20 years, Athimni's collective has supported numerous families in Tbainia, a village near the city of Ain Draham in a region with much higher poverty rates than the national average.

Women, who make up around 70 percent of the agricultural workforce, are the main breadwinners for their households in Tbainia.

- 'Yield less' -

Tunisia is in its sixth year of drought and has seen its water reserves dwindle, as temperatures have soared past 50 degrees Celsius (122 degrees Fahrenheit) in some areas during the summer.

The country has 36 dams, mostly in the northwest, but they are currently just 20 percent full -- a record low in recent decades.

The Tbainia women said they usually harvested plants like eucalyptus, rosemary and mastic year-round, but shrinking water resources and rare rainfall have siphoned oil output.

"The mountain springs are drying up, and without snow or rain to replenish them, the herbs yield less oil," said Athimni.

Mongia Soudani, a 58-year-old harvester and mother of three, said her work was her household's only income. She joined the collective five years ago.

"We used to gather three or four large sacks of herbs per harvest," she said. "Now, we're lucky to fill just one."

Forests in Tunisia cover 1.25 million hectares, about 10 percent of them in the northwestern region.

Wildfires fueled by drought and rising temperatures have ravaged these woodlands, further diminishing the natural resources that women like Soudani depend on.

In the summer of last year, wildfires destroyed around 1,120 hectares near Tbainia.

"Parts of the mountain were consumed by flames, and other women lost everything," Soudani recalled.

To adapt to some climate-driven challenges, the women received training from international organizations, such as the Food and Agriculture Organization (FAO), to preserve forest resources.

Still, Athimni struggles to secure a viable income.

"I can't fulfil my clients' orders anymore because the harvest has been insufficient," she said.

The collective has lost a number of its customers as a result, she said.

- 'No longer sustainable' -

A recent study by the Tunisian Forum for Economic and Social Rights (FTDES) highlighted how climate-induced damage to forests had severely impacted local communities.

"Women in particular suffer the consequences as their activities become more difficult and arduous," the study said.

Tunisia has ratified key international environmental agreements, including the 2015 Paris Climate Accord.

But environmental justice researcher Ines Labiadh, who oversaw the FTDES study, said implementation "remains incomplete".

In the face of these woes, the Tbainia harvesters, like many women working in the sector, will be forced to seek alternative livelihoods, said Labiadh.

"They have no choice but to diversify their activities," she said. "Relying solely on natural resources is no longer sustainable."

Back in the field, Bachra Ben Salah strives to collect whatever herbs she can lay her hands on.

"There's nothing we can do but wait for God's mercy," she said.