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Heat, Disease, Air Pollution: How Climate Change Impacts Health

Air pollution, such as the extremes seen in India's capital New Delhi, are just one way that fossil fuels affect human health. Arun SANKAR / AFP/File
Air pollution, such as the extremes seen in India's capital New Delhi, are just one way that fossil fuels affect human health. Arun SANKAR / AFP/File
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Heat, Disease, Air Pollution: How Climate Change Impacts Health

Air pollution, such as the extremes seen in India's capital New Delhi, are just one way that fossil fuels affect human health. Arun SANKAR / AFP/File
Air pollution, such as the extremes seen in India's capital New Delhi, are just one way that fossil fuels affect human health. Arun SANKAR / AFP/File

Growing calls for the world to come to grips with the many ways that global warming affects human health have prompted the first day dedicated to the issue at crunch UN climate talks starting next week.
Extreme heat, air pollution and the increasing spread of deadly infectious diseases are just some of the reasons why the World Health Organization has called climate change the single biggest health threat facing humanity.
Global warming must be limited to the Paris Agreement target of 1.5 degrees Celsius "to avert catastrophic health impacts and prevent millions of climate change-related deaths", according to the WHO.
However, under current national carbon-cutting plans, the world is on track to warm up to 2.9C this century, the UN said this week.
While no one will be completely safe from the effects of climate change, experts expect that most at risk will be children, women, the elderly, migrants and people in less developed countries which have emitted the least planet-warming greenhouse gases.
On December 3, the COP28 negotiations in Dubai will host the first "health day" ever held at the climate negotiations.
- Extreme heat -
This year is widely expected to be the hottest on record. And as the world continues to warm, even more frequent and intense heatwaves are expected to follow.
Heat is believed to have caused more than 70,000 deaths in Europe during summer last year, researchers said this week, revising the previous number up from 62,000.
Worldwide, people were exposed to an average of 86 days of life-threatening temperatures last year, according to the Lancet Countdown report earlier this week.
The number of people over 65 who died from heat rose by 85 percent from 1991-2000 to 2013-2022, it added.
And by 2050, more than five times more people will die from the heat each year under a 2C warming scenario, the Lancet Countdown projected.
More droughts will also drive rising hunger. Under the scenario of 2C warming by the end of the century, 520 million more people will experience moderate or severe food insecurity by 2050.
Meanwhile, other extreme weather events such as storms, floods and fires will continue to threaten the health of people across the world.
Air pollution
Almost 99 percent of the world's population breathes air that exceeds the WHO's guidelines for air pollution.
Outdoor air pollution driven by fossil fuel emissions kills more than four million people every year, according to the WHO.
It increases the risk of respiratory diseases, strokes, heart disease, lung cancer, diabetes and other health problems, posing a threat that has been compared to tobacco.
The damage is caused partly by PM2.5 microparticles, which are mostly from fossil fuels. People breathe these tiny particles into their lungs, where they can then enter the bloodstream.
While spikes in air pollution, such as extremes seen in India's capital New Delhi earlier this month, trigger respiratory problems and allergies, long-term exposure is believed to be even more harmful.
However it is not all bad news.
The Lancet Countdown report found that deaths from air pollution due to fossil fuels have fallen 16 percent since 2005, mostly due to efforts to reduce the impact of coal burning.
Infectious diseases
The changing climate means that mosquitoes, birds and mammals will roam beyond their previous habitats, raising the threat that they could spread infectious diseases with them.
Mosquito-borne diseases that pose a greater risk of spreading due to climate change include dengue, chikungunya, Zika, West Nile virus and malaria.
The transmission potential for dengue alone will increase by 36 percent with 2C warming, the Lancet Countdown report warned.
Storms and floods create stagnant water that are breeding grounds for mosquitoes, and also increase the risk of water-borne diseases such as cholera, typhoid and diarrhea.
Scientists also fear that mammals straying into new areas could share diseases with each other, potentially creating new viruses that could then jump over to humans.
Mental health
Worrying about the present and future of our warming planet has also provoked rising anxiety, depression and even post-traumatic stress -- particularly for people already struggling with these disorders, psychologists have warned.
In the first 10 months of the year, people searched online for the term "climate anxiety" 27 times more than during the same period in 2017, according to data from Google Trends cited by the BBC this week.

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Varieties

Rare Diseases often Go Undiagnosed or Untreated in Parts of Africa. A Project Seeks to Change That

Neurology student Henriette Dieng examines Abdou Diop, a patient with genetic neuropathy at Pedro Rodriguez's clinic in Dakar, Senegal, Friday, Jan. 10, 2025. (AP Photo/Annika Hammerschlag)
Neurology student Henriette Dieng examines Abdou Diop, a patient with genetic neuropathy at Pedro Rodriguez's clinic in Dakar, Senegal, Friday, Jan. 10, 2025. (AP Photo/Annika Hammerschlag)
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Rare Diseases often Go Undiagnosed or Untreated in Parts of Africa. A Project Seeks to Change That

Neurology student Henriette Dieng examines Abdou Diop, a patient with genetic neuropathy at Pedro Rodriguez's clinic in Dakar, Senegal, Friday, Jan. 10, 2025. (AP Photo/Annika Hammerschlag)
Neurology student Henriette Dieng examines Abdou Diop, a patient with genetic neuropathy at Pedro Rodriguez's clinic in Dakar, Senegal, Friday, Jan. 10, 2025. (AP Photo/Annika Hammerschlag)

Ndeye Lam visits the cemetery often, praying and gently touching the seashells laid out across her daughter’s gravesite.

“Mariama will always be here,” she said, stepping away from the grave and onto a path that winds through rows of monuments outlined with white tile, stone and sand.

At home, Lam and her husband Pathé smiled over an old video clip of their daughter beaming as she celebrated her 13th birthday with cake and sparklers. When the girl was little, she loved to play. By 13, her muscles had weakened, her spine had curved and stiffened and in her last months, she struggled increasingly to breathe.

She visited Fann hospital in Dakar, where neurologist Dr. Pedro Rodriguez Cruz measured her lung capacity. He suspects Mariama had SELENON-related myopathy, a muscular dystrophy that causes severe respiratory compromise. A new BiPAP machine might have helped to ease her breathing, but it was too late.

Globally, more than 350 million people live with rare diseases, most of them caused by a misstep hidden within their genes. Some conditions can be caught early and treated—but in parts of Africa where population data and resources are scarce, many people go undiagnosed. Rodriguez is trying to change that by connecting patients with genetic testing and medical support, while gathering key data from those patients and their families.

“Most rare disease data has been collected from people of European ancestry, so we have very little knowledge about what’s happening in other parts of the world, mainly in Africa,” Rodriguez said, The AP news reported.

His research is funded by organizations including the La Caixa Foundation in Spain and the National Ataxia Foundation in the United States. And he has consulted with scientists in China, France, Boston, and elsewhere around the world, documenting rare diseases and novel disease-causing gene variants.

That research is creating a library of genetic data for scientists and clinicians. Patients in Senegal are benefiting, too, with a path to diagnosis.

Genetic testing and diagnosis can be life-saving In Guediawaye, Fatoumata Binta Sané’s daughter Aissata has glutaric acidemia type I, an inherited disorder in which the body can’t process certain proteins properly. Her arms and legs are tightly drawn up toward her chest. She can’t walk or reach for things, speak, sit on her own or hold her head up. Sané cradles Aissata in her arms constantly, and the 8-year-old smiles at the sound of her mother’s voice.

In the U.S., newborns are screened for treatable genetic conditions. In Senegal, newborn screening is not routine. Infants who appear healthy at birth might go undiagnosed and experience irreversible decline. Glutaric acidemia type I, for example, can cause brain damage, seizures, coma and early death.

Sané is waiting for genetic testing results for Aissata’s one-year-old sister Aminata. Patients can live long, healthy lives if they start treatment before the onset of symptoms. That includes following a strict diet, avoiding protein-rich foods like nuts, fish and meat and taking the supplement L-carnitine. Though consultation with Rodriguez was free, lifelong treatment is not. If Aminata shares her sister’s disease, Sané will need government assistance to buy medication.

Prof. Moustapha Ndiaye, head of the neurology department at Fann, hopes young physicians will graduate prepared to assist rare disease patients not just in Senegal but in other African countries.

“Students travel from across Africa to study here,” Ndiaye said.

At the start of her career, Dr. Henriette Senghor saw patients who were hospitalized for months. Some died, and no one knew why.

“There was this problem—there was this void,” said Senghor, who’s now training with Rodriguez.

In 2021, Rodriguez established a partnership between the Cheikh Anta Diop University of Dakar and CNAG, the National Center for Genomic Analysis in Barcelona. Rodriguez collects patients’ blood samples and delivers the extracted DNA to Barcelona, where scientists sequence it, storing the answers it holds in a large database. Almost 1,300 participants—patients and families—have enrolled in his study of rare disease in West Africa.

Families cross borders for care In the Gambia, Fatou Samba’s sons Adama, 8, and Gibriel, 4, like to play soccer and feed the sheep in their backyard. On a recent afternoon, they took turns playing with a toy airplane and a globe. Adama, who hopes to be a pilot, pointed to where he wanted to go: the U.S. Outside, he started to climb a pile of bicycles propped up against the wall, and Gibriel followed.

“We’re climbing Mount Everest,” Adama said.

Standing on a bicycle wheel, Adama hesitated. Samba reached for him, setting him down on solid ground. There is a tiny scar on his forehead where broken skin has been stitched back together. Last year, Samba couldn’t explain his frequent falling, so she sought answers in Dakar. Rodriguez confirmed Adama had Duchenne muscular dystrophy. Gibriel's genetic test results are pending. Children often lose the ability to run or climb stairs first, and later can’t walk or raise their arms. In adulthood, they develop heart and breathing problems.

Both boys are taking corticosteroids, which can slow disease progression for patients diagnosed early.

“Without the medication, it would have been terrible. Once we started, after a few weeks we saw improvement,” Samba said. “Doctors are destined to investigate (the disease) and find a cure ... I pray doctors will find a cure.”

Data is the first step Back at Fann Hospital, Rodriguez and Senghor consult with Woly Diene, 25, and her mother and brother. When Diene was 15, she started falling at school. Soon, she felt pain throughout her body. She couldn’t move. She lost her hearing, the strength in her hands and control of the muscles in her face.

Diene, who comes from a rural village in Senegal, has riboflavin transporter deficiency. High doses of vitamin B2—a supplement available on Amazon—can slow, stop and even reverse damage from this condition that is fatal without treatment.

Diene took her first dose when she was diagnosed in August 2023. She still has some difficulty hearing, but Diene is walking again. She has regained the strength in her face and hands. Diene’s brother Thierno said vitamin B2 is expensive, but he knows his sister needs it for the rest of her life.

“I am happy,” Diene said, smiling. “I hope to keep improving.”

While efforts like these help patients, they also allow doctors to collect data—and that’s vital for rare disease research, policy and drug development, said Lauren Moore, chief scientific officer at the National Ataxia Foundation.

“The most prevalent diseases get the most attention and the most funding,” she said. “Data ... really is the first step.”

A $50,000 grant from the foundation allows Rodriguez and colleagues to enroll study participants in Senegal and Nigeria with inherited ataxias—which can lead to muscle weakness, loss of mobility, hearing and vision difficulties and life-shortening heart problems.

The USAID cuts have not affected his research, but grant awards are limited. Rodriguez, Senghor and Rokhaya Ndiaye, professor of human genetics at the University of Dakar, are making plans to ensure genetic testing continues in Senegal.

Global collaboration is essential, said Ndiaye—and strengthening local infrastructure is just as important.

“The need is there,” she said. “And we have a lot of hope.”