Mushers and Dogs Braved Horrific Alaska Winter to Deliver Lifesaving Serum 100 Years Ago

FILE - The snow-covered coastal plain area of the Arctic National Wildlife Refuge is seen, with the Brooks Range at right, Monday, Oct. 14, 2024, near Kaktovik, Alaska. (AP Photo/Lindsey Wasson)
FILE - The snow-covered coastal plain area of the Arctic National Wildlife Refuge is seen, with the Brooks Range at right, Monday, Oct. 14, 2024, near Kaktovik, Alaska. (AP Photo/Lindsey Wasson)
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Mushers and Dogs Braved Horrific Alaska Winter to Deliver Lifesaving Serum 100 Years Ago

FILE - The snow-covered coastal plain area of the Arctic National Wildlife Refuge is seen, with the Brooks Range at right, Monday, Oct. 14, 2024, near Kaktovik, Alaska. (AP Photo/Lindsey Wasson)
FILE - The snow-covered coastal plain area of the Arctic National Wildlife Refuge is seen, with the Brooks Range at right, Monday, Oct. 14, 2024, near Kaktovik, Alaska. (AP Photo/Lindsey Wasson)

The Alaska Gold Rush town of Nome faced a bleak winter. It was hundreds of miles from anywhere, cut off by the frozen sea and unrelenting blizzards, and under siege from a contagious disease known as the “strangling angel” for the way it suffocated children.
Now, 100 years later, Nome is remembering its saviors — the sled dogs and mushers who raced for more than five days through hypothermia, frostbite, gale-force winds and blinding whiteouts to deliver life-saving serum and free the community from the grip of diphtheria, The Associated Press reported.
Among the events celebrating the centennial of the 1925 “Great Race of Mercy” are lectures, a dog-food drive and a reenactment of the final leg of the relay, all organized by the Nome Kennel Club.
Remembering the mushers and dogs for ‘heroic effort’ “There’s a lot of fluff around celebrations like this, but we wanted to remember the mushers and their dogs who have been at the center of this heroic effort and ... spotlight mushing as a still-viable thing for the state of Alaska,” said Diana Haecker, a kennel club board member and co-owner of Alaska’s oldest newspaper, the Nome Nugget.
“People just dropped whatever they were doing," she said. "These mushers got their teams ready and went, even though it was really cold and challenging conditions on the trail.”
Other communities are also marking the anniversary — including the village of Nenana, where the relay began, and Cleveland, Ohio, where the serum run's most famous participant, a husky mix named Balto, is stuffed and displayed at a museum.
Jonathan Hayes, a Maine resident who has been working to preserve the genetic line of sled dogs driven on the run by famed musher Leonhard Seppala, is recreating the trip. Hayes left Nenana on Monday with 16 Seppala Siberian sled dogs, registered descendants of Seppala's team.
The historic trek to neutralize the diphtheria epidemic in Nome Diphtheria is an airborne disease that causes a thick, suffocating film to develop at the back of the throat; it was once a leading cause of death for children. The antitoxin used to treat it was developed in 1890, and a vaccine in 1923; it is now exceedingly rare in the U.S.
Nome, western Alaska’s largest community, had about 1,400 residents a century ago. Its most recent supply ship had arrived the previous fall, before the Bering Sea froze, without any doses of the antitoxin. Those the local doctor, Curtis Welch, had were outdated, but he wasn't worried. He hadn’t seen a case of diphtheria in the 18 years he had practiced in the area.
Within months, that changed. In a telegram, Welch pleaded with the U.S. Public Health Service to send serum: "An epidemic of diphtheria is almost inevitable here.”
The first death was a 3-year-old boy on Jan. 20, 1925, followed the next day by a 7-year-old girl. By the end of the month, there were more than 20 confirmed cases. The city was placed under quarantine.
West Coast hospitals had antitoxin doses, but it would take time to get them to Seattle and then onto a ship for Seward, an ice-free port south of Anchorage. In the meantime, enough for 30 people was found at an Anchorage hospital.
It still had to get to Nome. Airplanes with open-air cockpits were ruled out as unsuited for the weather. There were no roads or trains that reached Nome.
Instead, officials shipped the serum by rail to Nenana in interior Alaska, some 675 miles (1,086 kilometers) from Nome via the frozen Yukon River and mail trails.
Thanks to Alaska’s new telegraph lines and the spread of radio, the nation followed along, captivated, as 20 mushers — many of them Alaska Natives — with more than 150 dogs relayed the serum to Nome. They battled deep snow, whiteouts so severe they couldn’t see the dogs in front of them, and life-threatening temperatures that plunged at times to minus 60 degrees Fahrenheit (minus 51 degrees Celsius).
The antitoxin was transported in glass vials covered with padded quilts. Not a single vial broke.
Seppala, a Norwegian settler, left from Nome to meet the supply near the halfway point and begin the journey back. His team, led by his dog Togo, traveled more than 250 miles (320 kilometers) of the relay, including a treacherous stretch across frozen Norton Sound.
After about 5 1/2 days, the serum reached its destination on Feb. 2, 1925. A banner front-page headline in the San Francisco Chronicle proclaimed: “Dogs victors over blizzard in battle to succor stricken Nome.”
The official record listed five deaths and 29 illnesses. It’s likely the toll was higher; Alaska Natives were not accurately tracked.
Balto gains fame as unlikely dog to bring serum to Nome Seppala and Togo missed the limelight that went to his assistant, Gunnar Kaasen, who drove the dog team led by Balto into Nome. Balto was another of Seppala’s dogs, but was used to only haul freight after he was deemed too slow to be on a competitive team.
Balto was immortalized in movies and with statues in New York's Central Park and one in Anchorage intended as a tribute to all sled dogs. He received a bone-shaped key to the city of Los Angeles, where legendary movie actress Mary Pickford placed a wreath around his neck.
But he and several team members were eventually sold and kept in squalid conditions at a dime museum in Los Angeles. After learning of their plight, an Ohio businessman spearheaded an effort to raise money to bring them to Cleveland. After dying in 1933, Balto was mounted and placed on display at the Cleveland Museum of Natural History.
Iditarod pays homage to the serum run Today, the most famous mushing event in the world is the Iditarod Trail Sled Dog Race, which is not based on the serum run but on the Iditarod Trail, a supply route from Seward to Nome. Iditarod organizers are nevertheless marking the serum run's centennial, with a series of articles on its website and by selling replicas of the medallions each serum run musher received a century ago, race spokesperson Shannon Noonan said in an email. This year's Iditarod starts March 1.
“The Serum Run demonstrated the critical role sled dogs played in the survival and communication of remote Alaskan communities, while the Iditarod has evolved into a celebration of that tradition and Alaska’s pioneering spirit,” Noonan said.



Japan Approves Stem-cell Treatment for Parkinson's in World First

Parkinson's disease. John SAEKI, Adrian LEUNG / AFP
Parkinson's disease. John SAEKI, Adrian LEUNG / AFP
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Japan Approves Stem-cell Treatment for Parkinson's in World First

Parkinson's disease. John SAEKI, Adrian LEUNG / AFP
Parkinson's disease. John SAEKI, Adrian LEUNG / AFP

Japan has approved ground-breaking stem-cell treatments for Parkinson's and severe heart failure, one of the manufacturers and media reports said Friday, with the therapies expected to reach patients within months.

Pharmaceutical company Sumitomo Pharma said it received the green light for the manufacture and sale of Amchepry, its Parkinson's disease treatment that transplants stem cells into a patient's brain, said AFP.

Japan's health ministry also gave the go-ahead to ReHeart, heart muscle sheets developed by medical startup Cuorips that can help form new blood vessels and restore heart function, media reports said.

The treatments could be on the market and rolled out to patients as early as this summer, reports said, citing the health ministry, becoming the world's first commercially available medical products using (iPS) cells.

Japanese scientist Shinya Yamanaka won the Nobel Prize in 2012 for his research into iPS, which have the potential to develop into any cell in the body.

"I hope this will bring relief to patients not only in Japan but around the world," health minister Kenichiro Ueno told a press conference.

"We will promptly carry out all necessary procedures to ensure it reaches all patients without fail."

In a statement, Sumitomo Pharma said it had obtained "conditional and time-limited approval" for the manufacture and marketing of Amchepry under a system which is reportedly designed to get these products to patients as quickly as possible.

The approval is a kind of "provisional license", the Asahi newspaper said, after the safety and efficacy of the treatment was judged based on data from fewer patients than in ordinary clinical trials for drugs.

A trial led by Kyoto University researchers indicated that the company's treatment was safe and successful in improving symptoms.

The study involved seven Parkinson's patients aged between 50 and 69, with each receiving a total of either five million or 10 million cells implanted on both sides of the brain.

The iPS cells from healthy donors were developed into the precursors of dopamine-producing brain cells, which are no longer present in people with Parkinson's disease.

The patients were monitored for two years and no major adverse effects were found, the study said. Four patients showed improvements in symptoms.

Parkinson's disease is a chronic, degenerative neurological disorder that affects the body's motor system, often causing shaking and other difficulties in movement.

Worldwide, about 10 million people have the illness, according to the Parkinson's Foundation.

Currently available therapies "improve symptoms without slowing or halting the disease progression," the foundation says.

iPS cells are created by stimulating mature, already specialized, cells back into a juvenile state -- basically cloning without the need for an embryo.

The cells can be transformed into a range of different types of cells, and their use is a key sector of medical research.


Saudi Red Sea Authority Appoints Dr. Maryam Ali Ficociello as CEO

The Saudi Red Sea Authority (SRSA) logo
The Saudi Red Sea Authority (SRSA) logo
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Saudi Red Sea Authority Appoints Dr. Maryam Ali Ficociello as CEO

The Saudi Red Sea Authority (SRSA) logo
The Saudi Red Sea Authority (SRSA) logo

The Saudi Red Sea Authority (SRSA) has appointed Dr. Maryam Ali Ficociello as Chief Executive Officer effective March 22.

“Ficociello brings more than two decades of leadership experience spanning governance, risk management, resilience, and compliance across public and private sectors, including state-owned entities. She has also represented the Kingdom at various international forums,” SRSA said in a statement on Thursday.

Commenting on her appointment, Ficociello said: “It is an honor to join the Saudi Red Sea Authority at this pivotal stage in its journey. SRSA has a critical role in enabling a world-class coastal tourism sector that is safe, well-governed, and investment-ready, while protecting the Red Sea’s unique marine ecosystems.”

“I look forward to working with our stakeholders across government and industry to strengthen regulatory excellence, embed sustainability and resilience across the sector, and advance the Kingdom’s ambitions for responsible coastal tourism and the blue economy,” she added.


Tourism on Hold as Middle East War Casts Uncertainty

Tourism to the Middle East has boomed in recent years but war now threatens that success. Ryan Lim / AFP
Tourism to the Middle East has boomed in recent years but war now threatens that success. Ryan Lim / AFP
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Tourism on Hold as Middle East War Casts Uncertainty

Tourism to the Middle East has boomed in recent years but war now threatens that success. Ryan Lim / AFP
Tourism to the Middle East has boomed in recent years but war now threatens that success. Ryan Lim / AFP

Cancelled flights, postponed trips and a great deal of uncertainty: the war in the Middle East is casting a long shadow over the tourism outlook for a region that has become a prized destination for travelers worldwide.

"My last group of tourists left three days ago, and all the other groups planned for March have been cancelled," said Nazih Rawashdeh, a tour guide near Irbid, in northern Jordan.

"This is the start of the high season here. It's catastrophic," he told AFP.

"And yet there's no problem in Jordan. It's perfectly safe."

Across the world, tour operators are scrambling to find solutions for clients stranded in the region or who had trips planned there.

"The priority is getting those already there back home," said Alain Capestan, president of the French tour operator Comptoir des Voyages.

He said however that the war is also affecting customers who have travelled to other parts of the world, as the Gulf region is home to several major aviation hubs.

Like other companies, the German tour operators surveyed by AFP -- Alltours, Dertour, Schauinsland-Reisen -- announced they would cover the cost of extra nights for clients stranded in the Middle East. They also cancelled trips to the UAE and Oman until at least March 7.

The British travel industry association ABTA said agencies "would not be sending customers to the region for as long as the British Foreign Office advises against all non-essential travel".

Customers whose holidays were cancelled in recent days will be able to rebook or receive a refund, it said.

- Economic impact -

The war is disrupting a sector that had been booming in the region.

According to UN Tourism, in 2025 around 100 million tourists visited the Middle East -- nearly seven percent of all international tourists recorded worldwide. That figure had grown three percent year-on-year and 39 percent compared to the pre-pandemic period.

Depending on the destination, Europeans make up a large share of visitors, followed by tourists from South Asia, the Americas, and other Middle Eastern countries.

For example, nearby markets accounted for 26 percent of total visitors to Dubai in 2025, according to its Ministry of Tourism and Economy.

Against this backdrop analysts Oxford Economics warns that "a decline in tourist flows to the region will deal a more severe economic blow than in the past, as tourism's share of GDP has grown, as has employment in the sector".

"We estimate inbound arrivals to the Middle East could decline 11-27 percent year-on-year in 2026 due to the conflict, compared to our December forecast that projected 13 percent growth," said Director of Global Forecasting Helen McDermott.

That would translate, according to the firm, to between 23 and 38 million fewer international visitors compared to the prior scenario, and a loss of $34 to $56 billion in tourist spending.

After Covid and then the conflict in Gaza, tourists had been coming back, said Rawashdeh, the Jordanian tour guide.

"For the past six months, people working in tourism here had hope. And now there's a war. This is going to be terrible for the economy," he said.

"We've definitely noticed an understandable slowdown in new bookings from our partners right now, but we fully expect that to bounce back as soon as things settle down and travelers feel more confident," said Ibrahim Mohamed, marketing director of Middle East Travel Alliance, which offers direct tours to American and British operators.

He remains optimistic: "The Middle East has always been an incredibly resilient market, and demand always bounces back fast once stability returns."