3 days, 640,000 Children, 1.3M Doses...the Plan to Vaccinate Gaza's Young against Polio

FILE - Palestinians displaced by the Israeli air and ground offensive on the Gaza Strip, walk through a dark streak of sewage flowing into the streets of the southern town of Khan Younis, Gaza Strip, on July 4, 2024. Health authorities and aid agencies are racing to avert an outbreak of polio in the Gaza Strip after the virus was detected in the territory's wastewater and three cases with a suspected polio symptom have been reported. (AP Photo/Jehad Alshrafi, File)
TT

3 days, 640,000 Children, 1.3M Doses...the Plan to Vaccinate Gaza's Young against Polio

FILE - Palestinians displaced by the Israeli air and ground offensive on the Gaza Strip, walk through a dark streak of sewage flowing into the streets of the southern town of Khan Younis, Gaza Strip, on July 4, 2024. Health authorities and aid agencies are racing to avert an outbreak of polio in the Gaza Strip after the virus was detected in the territory's wastewater and three cases with a suspected polio symptom have been reported. (AP Photo/Jehad Alshrafi, File)

The UN health agency and partners are launching a campaign starting Sunday to vaccinate 640,000 Palestinian children in Gaza against polio, an ambitious effort amid a devastating war that has destroyed the territory's healthcare system.

The campaign comes after the first polio case was reported in Gaza in 25 years — a 10-month-old boy, now paralyzed in the leg. The World Health Organization says the presence of a paralysis case indicates there could be hundreds more who have been infected but aren’t showing symptoms.

Most people who have polio do not experience symptoms, and those who do usually recover in a week or so. But there is no cure, and when polio causes paralysis it is usually permanent. If the paralysis affects breathing muscles, the disease can be fatal.

The vaccination effort will not be easy: Gaza’s roads are largely destroyed, its hospitals badly damaged and its population spread into isolated pockets.

WHO said Thursday that it has reached an agreement with Israel for limited pauses in the fighting to allow for the vaccination campaign to take place. Even so, such a large-scale campaign will pose major difficulties in a territory blanketed in rubble, where 90% of Palestinians are displaced.

How long will it take? The three-day vaccination campaign in central Gaza will begin Sunday, during a “humanitarian pause” lasting from 6 a.m. until 3 p.m., and another day can be added if needed, said Dr. Rik Peeperkorn, WHO’s representative in the Palestinian territories.

In coordination with Israeli authorities, the effort will then move to southern Gaza and northern Gaza during similar pauses, he said during a news conference by video from Deir al-Balah in central Gaza, according to The AP.

Who will receive the vaccine? The vaccination campaign targets 640,000 children under 10, according to WHO. Each child will receive two drops of oral polio vaccine in two rounds, the second to be administered four weeks after the first.

Where are the vaccination sites? The vaccination sites span Gaza, both inside and outside Israeli evacuation zones, from Rafah in the south to the northern reaches of the territory.

The Ramallah-based Health Ministry said Friday that there would be over 400 “fixed” vaccination sites — the most in Khan Younis, where the population density is the highest and there are 239,300 children under 10. Fixed sites include healthcare centers, hospitals, clinics and field hospitals.

Elsewhere in the territory, there will also be around 230 “outreach” sites — community gathering points that are not traditional medical centers — where vaccines will be distributed.

Where are the vaccines now? Around 1.3 million doses of the vaccine traveled through the Kerem Shalom checkpoint and are currently being held in “cold-chain storage” in a warehouse in Deir al-Balah. That means the warehouse is able to maintain the correct temperature so the vaccines do not lose their potency.

Another shipment of 400,000 doses is set to be delivered to Gaza soon.

The vaccines will be trucked to distribution sites by a team of over 2,000 medical volunteers, said Ammar Ammar, a spokesperson for UNICEF.

What challenges lie ahead? Mounting any sort of campaign that requires traversing the Gaza strip and interacting with its medical system is bound to pose difficulties.

The UN estimates that approximately 65% of the total road network in Gaza has been damaged. Nineteen of the strip's 36 hospitals are out of service.

The north of the territory is cut off from the south, and travel between the two areas has been challenging throughout the war because of Israeli military operations. Aid groups have had to suspend trips due to security concerns, after convoys were targeted by the Israeli military.

Peeperkorn said Friday that WHO cannot do house-to-house vaccinations in Gaza, as they have in other polio campaigns. When asked about the viability of the effort, Peeperkorn said WHO thinks “it is feasible if all the pieces of the puzzle are in place. ”

How many doses do children need and what happens if they miss a dose? The World Health Organization says children typically need about three to four doses of oral polio vaccine — two drops per dose — to be protected against polio. If they don’t receive all of the doses, they are vulnerable to infection.

Doctors have previously found that children who are malnourished or who have other illnesses might need more than 10 doses of the oral polio vaccine to be fully protected.

Are there side effects? Yes, but they are very rare.

Billions of doses of the oral vaccine have been given to children worldwide and it is safe and effective. But in about 1 in 2.7 million doses, the live virus in the vaccine can paralyze the child who receives the drops.

How did this outbreak in Gaza start? The polio virus that triggered this latest outbreak is a mutated virus from an oral polio vaccine. The oral polio vaccine contains weakened live virus and in very rare cases, that virus is shed by those who are vaccinated and can evolve into a new form capable of starting new epidemics.



Experts: Baby in Gaza Has Strain of Polio Linked to Mistakes in Eradication Campaign

The mother of Palestinian boy Abdul Rahman Abu Al-Jidyan, who is the first person to contract polio in Gaza in 25 years, gestures as she looks after him in their tent, in Deir Al-Balah, in the central Gaza Strip August 28, 2024. REUTERS/Ramadan Abed
The mother of Palestinian boy Abdul Rahman Abu Al-Jidyan, who is the first person to contract polio in Gaza in 25 years, gestures as she looks after him in their tent, in Deir Al-Balah, in the central Gaza Strip August 28, 2024. REUTERS/Ramadan Abed
TT

Experts: Baby in Gaza Has Strain of Polio Linked to Mistakes in Eradication Campaign

The mother of Palestinian boy Abdul Rahman Abu Al-Jidyan, who is the first person to contract polio in Gaza in 25 years, gestures as she looks after him in their tent, in Deir Al-Balah, in the central Gaza Strip August 28, 2024. REUTERS/Ramadan Abed
The mother of Palestinian boy Abdul Rahman Abu Al-Jidyan, who is the first person to contract polio in Gaza in 25 years, gestures as she looks after him in their tent, in Deir Al-Balah, in the central Gaza Strip August 28, 2024. REUTERS/Ramadan Abed

The baby in Gaza who was recently paralyzed by polio was infected with a mutated strain of the virus that vaccinated people shed in their waste, according to scientists who say the case is the result of “an unqualified failure” of public health policy.
The infection, which marked the first detection of polio in the war-torn Palestinian territory in more than 25 years, paralyzed the lower part of one leg in the unvaccinated 10-month-old child. The baby boy was one of hundreds of thousands of children who missed vaccinations because of the fighting between Israel and Hamas.
Scientists who have been monitoring polio outbreaks said the baby's illness showed the failures of a global effort by the World Health Organization and its partners to fix serious problems in their otherwise largely successful eradication campaign, which has nearly wiped out the highly infectious disease. Separately, a draft report by experts deemed the WHO effort a failure and “a severe setback.”
The polio strain in question evolved from a weakened virus that was originally part of an oral vaccine credited with preventing millions of children worldwide from being paralyzed. But that virus was removed from the vaccine in 2016 in hopes of preventing vaccine-derived outbreaks.
Public health authorities knew that decision would leave people unprotected against that particular strain, but they thought they had a plan to ward off and quickly contain any outbreaks. Instead, the move resulted in a surge of thousands of cases, The Associated Press reported.
“It was a really horrible strategy,” said Columbia University virologist Vincent Racaniello, who was not involved with the report or the WHO. “The decision to switch vaccines was based on an incorrect assumption, and the result is now we have more polio and more paralyzed children.”
A draft copy of the report commissioned by the WHO and independent experts said the plan underestimated the amount of the strain in the environment and overestimated how well officials would be able to squash outbreaks.
The plan led to vaccine-linked polio outbreaks in 43 countries that paralyzed more than 3,300 children, the report concluded.
Even before the Gaza case was detected, officials reviewing the initiative to tinker with the vaccine concluded that “the worst-case scenario has materialized,” the report said.
The report has not yet been published, and some changes will likely be made before the final version is released next month, the WHO said.
The strain that infected the baby in Gaza had lingered in the environment and mutated into a version capable of starting outbreaks. It was traced to polio viruses spreading last year in Egypt, according to genetic sequencing, the WHO said.
In 2022, vaccine-linked polio viruses were found to be spreading in Britain, Israel and the US, where an unvaccinated man was paralyzed in upstate New York.
Scientists now worry that the emergence of polio in a war zone with an under-immunized population could fuel further spread.
Racaniello said the failure to track polio carefully and to sufficiently protect children against the strain removed from the vaccine has had devastating consequences.
“Only about 1% of polio cases are symptomatic, so 99% of infections are silently spreading the disease,” he said.
The oral polio vaccine, which contains a weakened live virus, was withdrawn in the US in 2000. Doctors continued to vaccinate children and eventually moved to an injected vaccine, which uses a dead virus and does not come with the risk that polio will be present in human waste. Such waste-borne virus could mutate into a form that triggers outbreaks in unvaccinated people.
The report's authors faulted leaders at the WHO and its partners, saying they were unable or unwilling “to recognize the seriousness of the evolving problem and take corrective action.”
WHO spokesman Oliver Rosenbauer acknowledged that the vaccine strategy “exacerbated” the risk of epidemics linked to the vaccine.
He said in an email that immunization “was not implemented in such a way to rapidly stop outbreaks or to prevent new strains from emerging.” Rosenbauer said not hitting vaccination targets was the biggest risk for allowing vaccine-linked viruses to emerge.
“You need to reach the children with the vaccines ... regardless of which vaccines are used,” he said.
The WHO estimates that 95% of the population needs to be immunized against polio to stop outbreaks. The UN health agency said only about 90% of Gaza’s population was vaccinated earlier this year.
To try to stop polio in Gaza and the wider region, the WHO and its partners plan two rounds of vaccination campaigns later this week and next month, aiming to cover 640,000 children. Authorities will use a newer version of the oral polio vaccine that targets the problematic strain. The weakened live virus in the new vaccine is less likely to cause vaccine-derived outbreaks, but they are still possible.
Racaniello said it was “unethical” that the WHO and its partners were using a vaccine that is unlicensed in rich countries precisely because it can increase the risk of polio in unvaccinated children.
The oral polio vaccine, which has reduced infections globally by more than 99%, is easy to make and distribute. Children require just two drops per dose that can be administered by volunteers. The oral vaccine is better at stopping transmission than the injected version, and it is cheaper and easier to administer.
But as the number of polio cases caused by the wild virus have plummeted in recent years, health officials have been struggling to contain the increasing spread of vaccine-linked cases, which now comprise the majority of polio infections in more than a dozen countries, in addition to Afghanistan and Pakistan, where transmission of the wild virus has never been stopped.
“This is the result of the Faustian bargain we made when we decided to use" the oral polio vaccine, said Dr. Paul Offit, director of the Vaccine Education Center at the University of Philadelphia. “If we really want to eradicate polio, then we need to stop using the vaccine with live (weakened) virus.”