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Oxford University to Test Universal Flu Vaccine in World First

A nurse vaccinates a patient as part of the start of the seasonal influenza vaccination campaign in Nice, southeastern France, October 21, 2015. REUTERS/Eric Gaillard
A nurse vaccinates a patient as part of the start of the seasonal influenza vaccination campaign in Nice, southeastern France, October 21, 2015. REUTERS/Eric Gaillard
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Oxford University to Test Universal Flu Vaccine in World First

A nurse vaccinates a patient as part of the start of the seasonal influenza vaccination campaign in Nice, southeastern France, October 21, 2015. REUTERS/Eric Gaillard
A nurse vaccinates a patient as part of the start of the seasonal influenza vaccination campaign in Nice, southeastern France, October 21, 2015. REUTERS/Eric Gaillard

A seasonal flu vaccine that would be the first in the world to fight all types of the virus is to be tested in a two-year clinical trial involving more than 2,000 patients by researchers in Oxford.

The so-called universal vaccine was developed by Oxford University’s Jenner Institute and Vaccitech, a spin-out biotech company founded by Jenner scientists.

Current flu vaccines have to be changed each year to match strains of virus circulating at the time and they do not always protect people that well, especially older patients with weak immune systems.

The new vaccine works by using proteins found in the core of the virus rather than those on its surface. Surface proteins stick out like pins from the virus and change all the time, while those in the core are stable.

Significantly, the new vaccine works by stimulating the immune system to boost virus-killing T-cells, instead of antibodies. Previous research has shown such T-cells can help fight more than one type of flu virus.

Researchers hope the new vaccine will provide better and longer-lasting protection when used alongside the regular seasonal flu shot.

“We’re hoping it will last two to three years - maybe even four years - but we really don’t know until we do the trials,” Vaccitech Chief Executive Tom Evans told Reuters.

The new vaccine has already been tested for safety in earlier trials. Now it is advancing into mid-stage Phase IIb testing, which will see the recruitment of at least 500 British subjects this season. The remainder will be recruited during the 2018/9 flu season.

It is the first time a universal flu vaccine has progressed beyond Phase I clinical testing.

Assuming it is successful in Phase IIb, the new shot will still have to go into much bigger and expensive final-stage testing and Evans said the plan would be to bring in a partner at this stage of development.

“We would look for a better-capitalized company to take this into final Phase III tests,” he said.

Leading manufacturers of seasonal flu vaccines include Sanofi, GlaxoSmithKline and CSL’s Seqirus, which includes the old Novartis flu vaccine business.

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Farmed Production of Some Fish - and Seaweed - is Soaring

Farmed salmon -- like the ones grown in pens here in the Australian island state of Tasmania -- are easier to grow than some other fish species. Gregory PLESSE / AFP/File
Farmed salmon -- like the ones grown in pens here in the Australian island state of Tasmania -- are easier to grow than some other fish species. Gregory PLESSE / AFP/File
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Farmed Production of Some Fish - and Seaweed - is Soaring

Farmed salmon -- like the ones grown in pens here in the Australian island state of Tasmania -- are easier to grow than some other fish species. Gregory PLESSE / AFP/File
Farmed salmon -- like the ones grown in pens here in the Australian island state of Tasmania -- are easier to grow than some other fish species. Gregory PLESSE / AFP/File

The amount of farmed seafood we consume -- as opposed to that taken wild from our waters -- is soaring every year, making aquaculture an ever-more important source for many diets, and a response to overfishing.

According to the UN's Food and Agriculture Organization, nearly 99 million tons of aquatic animals (fish, molluscs like oysters and mussels and crustaceans like prawns) were farmed around the world in 2023, five times more than three decades ago.

Since 2022, the farming of aquatic animals has been steadily overtaking fishing around the world -- but with large disparities from species to species.

Fast-growing species

The two biggest sellers on the market in 2023, carp and tilapia, mainly came from freshwater farming, while other widely-consumed fish, like herring, came just from deep sea fishing

Thierry Laugier, a researcher at Ifremer, France's national institute for ocean science and technology, told AFP that fish farmers choose species that grow quickly and with simple requirements, to be able to control the life cycle.

Sales of the most widely farmed fish in Europe, Atlantic salmon, came to 1.9 million tons in 2023, 99 percent of which were farmed.

"We know how to control the ageing or how to launch a reproduction cycle, through injecting hormones," Laugier said.

Asia main producer
Asia is by far the biggest producer of farmed fish, accounting for 92 percent of the 136 million tons -- of both animal and plant species -- produced under manmade conditions in 2023.

"For carp, it comes down to tradition, it has been farmed for thousands of years on the Asian continent," the Ifremer researcher said.

At the other end of the spectrum, sardines and herring are just fished in the oceans, mainly for profitability reasons as some fish grow very slowly.

"It takes around two years to get an adult-sized sardine," Laugier said.

He said farming of some fish has not yet been started as, "for a long time, we thought the ocean was an inexhaustible resource".

Seaweed

Little known in the West, seaweed nevertheless accounts for almost a third of world aquaculture production.

Almost exclusively from Asia, seaweed production increased by nearly 200 percent in two decades, to 38 million tons. It is mainly used in industry, in jellies, pharmaceuticals and cosmetics, the expert said.

He said seaweed also has the major advantage of absorbing not just CO2 in the oceans, but also nitrogen and certain pollutants.

"And from an ecological point of view it is better to farm macroalgae than salmon," Laugier said.