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Arthritis Drugs May Treat Depression

Close-up of doctor holding a pills in the hands (iStock)
Close-up of doctor holding a pills in the hands (iStock)
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Arthritis Drugs May Treat Depression

Close-up of doctor holding a pills in the hands (iStock)
Close-up of doctor holding a pills in the hands (iStock)

Scientists at the University of Cambridge said anti-inflammatory drugs could offer hope for people with depression.

New avenues for potential treatment were highlighted after the examination of genetic data from 370,000 Britons to explore the condition’s links to heart disease and inflammation, they explained.

The research led by Dr. Golam Khandaker of the University of Cambridge, suggests that blood proteins linked to inflammation are likely to play a part in causing depression, adding that the work offered a "new explanation for a major mental illness."

It has been known for decades that people with heart disease are more likely to suffer from depression, but the biological link was not understood.

The study published in the journal "Molecular Psychiatry" suggests that inflammation, which is a natural response against harmful environmental factors, anxiety or infection - is a key link to depression.

Khandaker is currently testing the tocilizumab, an anti-inflammatory drug used for the treatment of rheumatoid arthritis, to see if reducing inflammation leads to improvement in mood and cognitive function in patients with depression.

If the test goes well, the results could alter the treatments of depression, as the majority of drugs used to cure depression affect the way the brain works and transmits serotonin.

The new research also answers some questions such as why do exercises that reduce inflammation improve depression symptoms. It also assumes that avoiding sugar, fat and smoking - all of which increase inflammation - promotes mental and psychological health.

First, the team looked at whether family history of coronary heart disease was associated with risk of major depression. They found that people who reported at least one parent having died of heart disease were 20 percent more likely to develop depression at some point in their life.

Next, the researchers calculated a genetic risk score for coronary heart disease, but they found no strong association between heart disease and the likelihood of experiencing depression.

Later, the team investigated 15 biomarkers - biological 'red flags' - associated with increased risk of coronary heart disease. They found that triglycerides and the inflammation-related proteins IL-6 and CRP were also risk factors for depression. Both IL-6 and CRP are inflammatory markers that are produced in response to damaging stimuli, such as infection, stress or smoking.

"It is possible that heart disease and depression share a biological mechanism with a key link that leads to the emergence of two types of disease in two different organs of the body : the heart, blood vessels, and brain. Our study assumes that inflammation may reflect this common link," The Times newspaper quoted Khandaker as saying.

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An Iconic Puzzle Comes Home as Production of the Rubik’s Cube Returns to Hungary

Hungarian architect and inventor Ernő Rubik attends the opening event of Rubik's Cube production line of the Jasz-Plasztik plastic processing company in Jaszbereny, Hungary, 10 November 2026. (EPA)
Hungarian architect and inventor Ernő Rubik attends the opening event of Rubik's Cube production line of the Jasz-Plasztik plastic processing company in Jaszbereny, Hungary, 10 November 2026. (EPA)
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An Iconic Puzzle Comes Home as Production of the Rubik’s Cube Returns to Hungary

Hungarian architect and inventor Ernő Rubik attends the opening event of Rubik's Cube production line of the Jasz-Plasztik plastic processing company in Jaszbereny, Hungary, 10 November 2026. (EPA)
Hungarian architect and inventor Ernő Rubik attends the opening event of Rubik's Cube production line of the Jasz-Plasztik plastic processing company in Jaszbereny, Hungary, 10 November 2026. (EPA)

More than half a century ago, a Hungarian architect, sculptor and professor invented what would become one of the world's most popular and beloved puzzles whose appeal has spanned generations: the colorful, mind-bending, six-sided Rubik's Cube.

Now, after selling more than half a billion units and becoming a worldwide cultural touchstone, production of the cube is returning to Hungary, where its inventor, Ernő Rubik, first conceived of the iconic object that bears his name.

Hungary “is the home of the cube. The cube was born here,” Rubik, 82, said on Tuesday at the opening of a new, fully automated Rubik's Cube production line in the Hungarian city of Jászberény.

The journey of the Rubik's Cube began in 1974, when Rubik was teaching design at the Academy of Applied Arts and Design in Budapest. Seeking to create a three-dimensional object that was “infinite,” he said, he completed a prototype — then made of wood — of a cube that could rotate on multiple axes and was made up of 27 blocks.

Recognizing its consumer value, Rubik soon began producing more of the puzzles. Beginning in 1977, an initial 5,000 units of what was then called the “Magic Cube” were sold at specialty shops in the Hungarian capital.

The invention — or what Rubik prefers to describe as a “discovery” — gained popularity, and after having difficulties procuring materials for the cubes in then-socialist Hungary, he realized: “We were not prepared for that size of production ... We can’t fulfill the needs of the market worldwide.”

The cube was licensed to a British and then a US toy company, and its production was moved abroad. By the early 1980s, its popularity had exploded in what Rubik called “the first big wave,” in which he said 200 million units were sold between 1980 and 1983.

While sales of the cube dipped after its initial success, it still attracts plenty of users eager to try their hand at solving the puzzle. Millions are sold every year.

At the new production line in Hungary, a series of robotic arms assembles the cubes and tests them for functionality and durability — a level of automation Rubik said was “very different” than in the early days when the cubes were assembled by hand.

The new line in Jászberény plans to produce 1 million cubes annually.

Steve Radewych, a senior vice president with Canadian toy company Spin Master, which owns the Rubik's Cube trademark, said at Tuesday's opening that the theme of the day was: “Back to its roots: The cube comes home.”

“Ernő, your discovery is more than a toy,” Radewych told Rubik. “It's a global social phenomenon.”

Radewych noted the “incredible staying power” of the Rubik's Cube, and the fact that the puzzle continues to hold the fascination of young people even today.

“The cube represents an intellectual journey, a symbol of intelligence, problem-solving and cognitive discipline,” he added, which “has brought joy — and frustration — to many generations.”

The cube has enjoyed another surge in popularity in recent years as global competitions have proliferated, measuring who can solve the puzzle the fastest.

The current record, set only last month in China by nine-year-old Xuanyi Geng, is 2.51 seconds, according to the World Cube Association, which organizes and certifies competitions across the world.

Rubik, who does not consider himself a speed competitor, said that for him, the cube represents a “transformable sculpture,” the place where art and engineering meet and users can manipulate and change the cube in nearly endless variations.

“If you are doing something, creating something, you have the chance to do something that is meaningful — that’s one part — and beautiful,” he said.

Varieties

SpaceX Starship Test to Attempt First-Ever Spaceship ‘Catch'

SpaceX's mega rocket Starship is stacked and prepared for a test flight from Starbase, Texas, Thursday, Nov. 12, 2026. (AP)
SpaceX's mega rocket Starship is stacked and prepared for a test flight from Starbase, Texas, Thursday, Nov. 12, 2026. (AP)
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SpaceX Starship Test to Attempt First-Ever Spaceship ‘Catch'

SpaceX's mega rocket Starship is stacked and prepared for a test flight from Starbase, Texas, Thursday, Nov. 12, 2026. (AP)
SpaceX's mega rocket Starship is stacked and prepared for a test flight from Starbase, Texas, Thursday, Nov. 12, 2026. (AP)

Elon Musk's SpaceX was poised Friday to carry out its latest test of the world's biggest and most powerful rocket, the Starship, with plans for a groundbreaking "catch" of the spaceship following a day in orbit.

A successful capture of the Starship upper stage would mark a significant milestone in the space industry's decades-long pursuit of fully reusable spacecraft that can drastically reduce mission costs and make frequent travel possible.

"If successful, this will mark the first full recovery of an orbital launch system and a breakthrough moment in making Starship a reliable, rapidly reusable rocket," SpaceX said.

For the 15th Starship test flight Friday, SpaceX aims to recover both stages of the massive 124-meter (407-foot) launch vehicle.

The company has caught the booster, dubbed Super Heavy, on three previous occasions, with the first stage descending vertically back to the launch site shortly after blastoff and nestling into mechanical "chopstick" arms.

It will now attempt to do the same with the spaceship. Some versions of the vessel are designed to launch internet satellites and data centers into orbit, while others will be made to ferry people to the Moon and Mars.

A spacecraft that can be fully reused is the "Holy Grail" of the space industry, said Clayton Swope, an aerospace expert at the Center for Strategic and International Studies.

"No one's really been able to do that so far," he said. "People have been trying to do that since the (NASA) space shuttle. But the space shuttle ended up being kind of a compromise because a lot of the vehicle wasn't reusable."

Reusing the Starship spacecraft would require the vessel to withstand the extreme heat of reentering Earth's atmosphere and then return to service without extensive refurbishment.

- Refueling challenge -

Musk, the world's richest person, has already revolutionized the space sector with the partially reusable Falcon rockets, which are regularly employed to launch satellites and carry astronauts to the International Space Station.

The Starship project, however, has been plagued by years-long delays as SpaceX grapples with novel engineering challenges -- even as NASA is counting on the spaceship to serve as a lunar lander for its Artemis program.

Other technical challenges include transferring fuel to Starship in orbit -- a requirement for any journey to the Moon or Mars.

Following SpaceX's high-profile stock market debut in June, the company carried out the first orbital flight of Starship in September, though the mission was cut short due to an engine issue.

It is also investing heavily in additional launch sites for its mega-rocket in Louisiana and Florida.

- Complex capture -

Friday's launch is scheduled to take place at SpaceX's "Starbase" in southern Texas at 4:45 pm (2245 GMT).

Following liftoff and the mid-air separation of the two stages, SpaceX plans to bring Super Heavy back to Earth six and a half minutes later, catching it at the launch site on the Gulf of Mexico coastline.

The spaceship will continue to reach Earth's orbit, where it will deploy 26 satellites into Musk's Starlink satellite internet constellation that has become a major revenue stream for SpaceX.

It will then circle the planet 14 times, before returning 22 hours later and -- SpaceX hopes -- descending safely into the chopstick arms.

This capture attempt is more complex than that of the booster, as the spaceship will be descending much faster and from a much greater altitude.

SpaceX has said it would proceed with these maneuvers only if conditions are optimal, and in the past has made last-minute changes to test flights under Musk's "fail fast" strategy of learning through crashes, explosions and other mishaps.

As of late Thursday, the US Federal Aviation Administration had not yet given its final approval for the test flight.

Varieties

Delhi Overtakes Lahore as World’s Most Polluted City as Air Quality Drops

Traffic moves on a smoggy morning as air pollution spikes in New Delhi, India, November 13, 2026. (Reuters)
Traffic moves on a smoggy morning as air pollution spikes in New Delhi, India, November 13, 2026. (Reuters)
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Delhi Overtakes Lahore as World’s Most Polluted City as Air Quality Drops

Traffic moves on a smoggy morning as air pollution spikes in New Delhi, India, November 13, 2026. (Reuters)
Traffic moves on a smoggy morning as air pollution spikes in New Delhi, India, November 13, 2026. (Reuters)

India's capital Delhi overtook Lahore in Pakistan to become the world's most polluted city on Friday, with air quality reaching hazardous levels and visibility dropping as smog blanketed the city of 20 million people.

Air quality index (AQI) in Delhi was "hazardous" at 334, making ‌it the ‌most polluted global major ‌city, ⁠according to Swiss group ⁠IQAir, which measures air quality levels based on the concentration of toxins.

An AQI reading up to 50 is considered good with little or no ⁠health risk.

India's official ‌Central Pollution ‌Control Board pegged the AQI higher at ‌403 and rated it "severe".

The ‌Swiss and Indian readings vary due to the different AQI scales and methodologies used to calculate and ‌classify air pollution levels.

Cars and motorcycles emerged from dense ⁠smog, ⁠which also appeared to obscure streetlights on the city's main roads, videos from news agency ANI showed.

Pollution is a seasonal problem in many parts of northern India and neighboring Pakistan, as the cold, heavy air of winter traps vehicle emissions, construction dust and smoke from agricultural burning.