A Soyuz rocket blasted off on Wednesday from the Baikonur space center in Kazakhstan carrying an Emirati who is set to make history as the first Arab on the International Space Station.
The Russian rocket carrying the three-member crew -- including Hazzaa al-Mansoori of the United Arab Emirates -- took off as scheduled at 1357 GMT.
Mansoori, 35, is accompanied by Russia's Oleg Skripochka and NASA astronaut Jessica Meir.
They are expected to dock at the station just under six hours after launch.
"Everything continues to go smoothly for this ride," a commentator said on NASA television seven minutes after the launch.
Russia's Roscosmos space agency said on Twitter that the spacecraft had successfully reached orbit.
Mansoori received support from around the world before what he described as his "dream" mission.
He was seen showing his fist in the air before the launch.
In Dubai, a crowd gathered at the Mohammed Bin Rashid Space Centre to watch the launch, erupting in cheers and dubbing Mansoori a national hero. Some carried UAE flags.
Dubai's iconic Burj Khalifa, the world's tallest skyscraper, lit up the moment of blast-off.
Mansoori will spend eight days on the ISS and will be the first Emirati and the first Arab on the orbiting laboratory, but not the first Muslim.
Writing on Twitter before the launch, the former pilot in the UAE armed forces said he was "filled with this indescribable feeling of glory and awe".
"Today I carry the dreams and ambition of my country to a whole new dimension. May Allah grant me success in this mission," he said.
The day before the launch, he said he would record his prayer routine on the ISS and broadcast it to people on Earth.
"As a fighter pilot I already prayed in my aircraft," he said, explaining that he had experience of prayers at high speed.
Mansoori plans to conduct experiments and said he would take Emirati food with him to share with the crew.
Skripochka, first-time flyer Meir and Mansoori will join a six-member crew on the ISS and for a brief period of time the ISS will be home to nine astronauts.
At a pre-flight conference, Meir, 42, said the crew communicated by using "Runglish" - a mixture of Russian and English.
"We still need to work on our Arabic," she joked.
Mansoori is set to return to Earth with NASA's Nick Hague and Russian cosmonaut Alexey Ovchinin on October 3. Skripochka and Meir are set to remain on the ISS until the spring of 2020.
The first Arab in outer space was Saudi Arabia's Sultan bin Salman Al-Saud, who flew on a US shuttle mission in 1985.
Two years later, Syrian air force pilot Muhammed Faris spent a week aboard the Soviet Union's Mir space station.
As part of its space plans, the UAE has also announced its aim to become the first Arab country to send an unmanned probe to orbit Mars by 2021, naming it "Hope".
The International Space Station -- a rare example of cooperation between Russia and the West -- has been orbiting Earth at about 28,000 kilometers (17,000 miles) per hour since 1998.
Russia is resolved to keep its position as a leader of the space industry, particularly for manned space flights.