Does Human Growth Hormone Slow the Aging Process?

Does Human Growth Hormone Slow the Aging Process?
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Does Human Growth Hormone Slow the Aging Process?

Does Human Growth Hormone Slow the Aging Process?

Q. I haven't heard much about human growth hormone lately. Is there any new evidence to support its use in helping older men?

A. The pituitary gland in the brain makes and secretes natural growth hormone. In combination with other hormones, such as IGF-1 (insulin growth factor 1), it is responsible for body development early in life.

Throughout your life, growth hormone continues to play a role in protein production and helps the body use fat for energy. Children deficient in growth hormone do not grow to their full potential height and have short stature. The FDA approved a synthetic human growth hormone (HGH) as a replacement in these children, which helps them grow taller.

In the early 1980s, synthetic HGH became a popular but illegal performance-enhancing drug. The hype around HGH and superior athletic performance has always been greater than the reality. In fact, multiple clinical trials comparing HGH to a placebo have never shown an athletic advantage for people who use it.

As we age, the amount of growth hormone secreted by our pituitary gland naturally declines. By age 55, blood levels of growth hormone are about one-third lower than they are in people ages 18 to 35. This drop also coincides with the reduced muscle mass and increased body fat that happens with aging.

It's easy to see why HGH was touted as an "anti-aging" supplement. But does it make you feel and look 10 years younger, as some would suggest? We do know that healthy adults who take HGH can increase muscle by about 6% and reduce body fat by about the same amount. Strength also improves in some muscle groups, but not in all.

But there are downsides to using HGH. It can cause insulin to be less effective, which can raise blood sugar levels and increase the risk of diabetes. HGH also can lead to joint and muscle pain, breast enlargement, fluid retention, high blood pressure, and carpal tunnel syndrome. And then there is this: animal studies suggest that lower levels of growth hormone activity may lead to longer life. So, theoretically, HGH injections might actually shorten life span, challenging the notion that HGH is anti-aging.

The FDA has approved HGH in adults only for a few uncommon conditions, such as documented growth hormone deficiency. Synthetic human growth hormone is a prescription drug and cannot be obtained legally without a doctor's approval. To have any effect, it must be injected. Don't waste your money on pills containing HGH. The active ingredient is not absorbed when taken by mouth.

You can slow the tick of the clock with the time-tested formula of eating a healthy diet with enough protein and pursuing a regular program of aerobic and resistance exercise. This approach is better than any drug for enhancing your vigor and enjoyment of life.

by Howard LeWine, M.D.
Editor in Chief, Harvard Men's Health Watch



S.Africa's Iconic Protea Flower Relocates as Climate Warms

Protea flower grower Nico Thuynsma cultivates the blooms north of Johannesburg, 1,500 km (930 miles) from their natural home at the southern tip of Africa. Phill Magakoe / AFP
Protea flower grower Nico Thuynsma cultivates the blooms north of Johannesburg, 1,500 km (930 miles) from their natural home at the southern tip of Africa. Phill Magakoe / AFP
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S.Africa's Iconic Protea Flower Relocates as Climate Warms

Protea flower grower Nico Thuynsma cultivates the blooms north of Johannesburg, 1,500 km (930 miles) from their natural home at the southern tip of Africa. Phill Magakoe / AFP
Protea flower grower Nico Thuynsma cultivates the blooms north of Johannesburg, 1,500 km (930 miles) from their natural home at the southern tip of Africa. Phill Magakoe / AFP

On his farm two hours north of Johannesburg, Nico Thuynsma gestured towards thousands of orange, yellow and pink proteas in flower and thriving 1,500 kilometers (930 miles) from their natural home at the southern tip of Africa.

"They're all different," the 55-year-old farmer said of the assorted blooms from the diverse Proteaceae family that has more than 350 species in South Africa, from firework-like "pincushion" varieties to delicate "blushing brides".

He picked out a majestic pink and white crown, nearly the size of his head, that has taken four years to reach its impressive size. "The King Proteas are very slow to grow," Thuynsma said.

The largest of the proteas, the King Protea, is South Africa's national flower.

It has lent its name to the national cricket team and countless brands. It features on the currency and is the logo for South Africa's presidency this year of the G20 group of leading economies, which convenes a summit in November.

It is also the country's largest flower export with more than 10 million stems sent abroad last year, worth close to 275 million rand ($15 million), according to the Cape Flora industry organization, said AFP.

Its status offers the King Protea some protection but almost half of South Africa's other protea species face extinction because of pressures on their native habitats in the mountains of the Cape, according to South Africa's National Biodiversity Institute (SANBI).

These include habitat loss to agriculture, the proliferation of invasive alien species and "changes to natural fire cycles", SANBI said in a 2021 report.

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"People come to South Africa to see proteas," Nigel Barker, a professor in plant sciences at the University of Pretoria, told AFP. "It's the plant equivalent of the elephant or the lion."

Most proteas are endemic or semi-endemic to the Cape Floral Kingdom biome of "fynbos" ("fine bush") that stretches across the southern tip of South Africa and is one of the world's richest flora biodiversity hotspots.

But climate projections predict "hotter, drier conditions", Barker said. "We'll be looking at a completely different vegetation type in the future, semi-desert almost in some places."

"Many species, because they're so range-restricted, will probably go extinct under those scenarios," he said.

"The only solution we have is to cultivate them artificially... in greenhouses or farms where you control irrigation," Barker said.

An example is Thuynsma's farm in the grasslands of the north, where he began planting proteas three decades ago.

Here, winters are dry and frosty, and the summers rainy -- conditions very different to those in the far south where the proteas are at home.

Gel for irrigation

Through trial and error, Thuynsma has been able to cultivate close to 200 protea varieties, including some long forgotten and abandoned by farmers in their original habitats.

In his latest experiment, he has planted 36 varieties with just two liters (four pints) of saturated gel for irrigation.

"I hope to unlock the power of some of these varieties," Thuynsma said. "They come from the Western Cape out of very harsh conditions, so they do have it in them."

"I learn from them, I learn with them. And, hopefully, in the future I can advise my nursery public -- and even estates -- how to plant this lovely fynbos without irrigation," he said.

"I don't think I have a solution for climate change," he joked, crouched over a small seedling in freshly turned soil. "But I do have a solution: to plant proteas."

A few meters (yards) away, in a warm nursery, thousands of protea sprouts awaited their turn in the soil.

"I love them, I protect them, I collect them," Thuynsma said. "The protea is part of South Africa's DNA."