Human Saliva Has Potential to Evolve Into Venom

 Snakes hang from a wooden cabinet marked with the Chinese
characters "poisonous snake", at a snake soup shop ahead of the Spring
Festival in Hong Kong. Photo: Reuters
Snakes hang from a wooden cabinet marked with the Chinese characters "poisonous snake", at a snake soup shop ahead of the Spring Festival in Hong Kong. Photo: Reuters
TT
20

Human Saliva Has Potential to Evolve Into Venom

 Snakes hang from a wooden cabinet marked with the Chinese
characters "poisonous snake", at a snake soup shop ahead of the Spring
Festival in Hong Kong. Photo: Reuters
Snakes hang from a wooden cabinet marked with the Chinese characters "poisonous snake", at a snake soup shop ahead of the Spring Festival in Hong Kong. Photo: Reuters

Humans have the potential to become venomous due the genetic similarities between our saliva glands and a snake's venom glands, say scientists.

A joint research team from Japan's Okinawa Institute of Science and Technology Graduate University (OIST) and the Australian National University, found that the genetic foundation required for oral venom to evolve is present in both reptiles and mammals.

Reporting this in the journal PNAS on April 6, the researchers provided the first concrete evidence of an underlying molecular link between venom glands in snakes and salivary glands in mammals.

Venoms are a cocktail of proteins that animals have weaponized to immobilize and kill prey, as well as for self-defense. What's interesting about venom is that it has arisen in so many different animals: jellyfish, spiders, scorpions, snakes, and even some mammals. Although these animals evolved different ways to deliver venom, an oral system, where venom is injected through a bite is one of the most common.

In the study, the team looked at the genes that played important roles in protecting the cells from stress caused by producing lots of proteins. The genes were also key in regulating protein modification and folding. The scientists used venom glands collected from the Taiwan habu snake, a pit viper found in Asia.

The researchers identified around 3,000 of these 'cooperating' genes. Then, they studied the genomes of other creatures across the animal kingdom, including mammals like dogs, chimpanzees and humans, and found that they contained their own versions of these genes.

When the team looked at the salivary gland tissues within mammals, they found that the genes had a similar pattern of activity to that seen in snake venom glands. The scientists therefore think that salivary glands in mammals and venom glands in snakes share an ancient functional core that has been maintained since the two lineages split hundreds of millions of years ago.



Oleg Gordievsky, Britain’s Most Valuable Cold War Spy inside the KGB, Dies at 86

Former Russian KGB Colonel Oleg Gordievsky receives the Companion of the Most Distinguished Order of St Michael and Saint George from Queen Elizabeth II at Buckingham Palace in London, October 18, 2007. (AFP)
Former Russian KGB Colonel Oleg Gordievsky receives the Companion of the Most Distinguished Order of St Michael and Saint George from Queen Elizabeth II at Buckingham Palace in London, October 18, 2007. (AFP)
TT
20

Oleg Gordievsky, Britain’s Most Valuable Cold War Spy inside the KGB, Dies at 86

Former Russian KGB Colonel Oleg Gordievsky receives the Companion of the Most Distinguished Order of St Michael and Saint George from Queen Elizabeth II at Buckingham Palace in London, October 18, 2007. (AFP)
Former Russian KGB Colonel Oleg Gordievsky receives the Companion of the Most Distinguished Order of St Michael and Saint George from Queen Elizabeth II at Buckingham Palace in London, October 18, 2007. (AFP)

Oleg Gordievsky, a Soviet KGB officer who helped change the course of the Cold War by covertly passing secrets to Britain, has died. He was 86.

Gordievsky died March 4 in England, where he had lived since defecting in 1985. Police said Saturday that they are not treating his death as suspicious.

Historians consider Gordievsky one of the era’s most important spies. In the 1980s, his intelligence helped avoid a dangerous escalation of nuclear tensions between the USSR and the West.

Born in Moscow in 1938, Gordievsky joined the KGB in the early 1960s, serving in Moscow, Copenhagen and London, where he became KGB station chief.

He was one of several Soviet agents who grew disillusioned with the USSR after Moscow’s tanks crushed the Prague Spring freedom movement in 1968, and was recruited by Britain's MI6 in the early 1970s.

The 1990 book “KGB: The Inside Story,” co-authored by Gordievsky and British intelligence historian Christopher Andrew, says Gordievsky came to believe that “the Communist one-party state leads inexorably to intolerance, inhumanity and the destruction of liberties.” He decided that the best way to fight for democracy “was to work for the West.”

He worked for British intelligence for more than a decade during the chilliest years of the Cold War.

In 1983, Gordievsky warned the UK and US that the Soviet leadership was so worried about a nuclear attack by the West that it was considering a first strike. As tensions spiked during a NATO military exercise in Germany, Gordievsky helped reassure Moscow that it was not precursor to a nuclear attack.

Soon after, US President Ronald Reagan began moves to ease nuclear tensions with the Soviet Union.

In 1984, Gordievsky briefed soon-to-be Soviet leader Mikhail Gorbachev ahead of his first visit to the UK — and also briefed the British on how to approach the reformist Gorbachev. Gorbachev's meeting with Prime Minister Margaret Thatcher was a huge success.

Most senior Soviet spy to defect Ben Macintyre, author of a book about the double agent, “The Spy and the Traitor,” told the BBC that Gordievsky managed “in a secret way to launch the beginning of the end of the Cold War.”

Gordievsky was called back to Moscow for consultations in 1985, and decided to go despite fearing — correctly — that his role as a double agent had been exposed. He was drugged and interrogated but not charged, and Britain arranged an undercover operation to spirit him out of the Soviet Union — smuggled across the border to Finland in the trunk of a car.

He was the most senior Soviet spy to defect during the Cold War. Documents declassified in 2014 showed that Britain considered Gordievsky so valuable that Thatcher sought to cut a deal with Moscow: If Gordievsky’s wife and daughters were allowed to join him in London, Britain would not expel all the KGB agents he had exposed.

Moscow rejected the offer, and Thatcher ordered the expulsion of 25 Russians, despite objections from Foreign Secretary Geoffrey Howe, who fared it could scuttle relations just as Gorbachev was easing the stalemate between Russia and the West.

Moscow responded by expelling 25 Britons, sparking a second round in which each side kicked out six more officials. But, despite Howe’s fears, diplomatic relations were never severed.

Gordievsky’s family was kept under 24-hour KGB surveillance for six years before being allowed to join him in England in 1991. He lived the rest of his life under UK protection in the quiet town of Godalming, 40 miles (64 kilometers) southwest of London.

In Russia, Gordievsky was sentenced to death for treason. In Britain, Queen Elizabeth II appointed him a Companion of the Order of St. Michael and St. George in 2007 for “services to the security of the United Kingdom.” It is the same accolade held by the fictional British spy James Bond.

In 2008, Gordievsky claimed he had been poisoned and spent 34 hours in a coma after taking tainted sleeping pills given to him by a Russian business associate.

The risks he faced were underscored in 2018 when former Russian intelligence officer Sergei Skripal and his daughter were poisoned and seriously sickened with a Soviet-made nerve agent in the English city of Salisbury, where he had been living quietly for years.

The Surrey Police force said officers were called to an address in Godalming on March 4, where “an 86-year-old man was found dead at the property.”

It said counterterrorism officers are leading the investigation, but “the death is not currently being treated as suspicious” and “there is nothing to suggest any increased risk to members of the public.”