Drug Prescribed for Rheumatoid Arthritis Cures Eczema in 16 Weeks

Pedestrians stand outside Mount Sinai Medical Center. (AP Photo/John Minchillo)
Pedestrians stand outside Mount Sinai Medical Center. (AP Photo/John Minchillo)
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Drug Prescribed for Rheumatoid Arthritis Cures Eczema in 16 Weeks

Pedestrians stand outside Mount Sinai Medical Center. (AP Photo/John Minchillo)
Pedestrians stand outside Mount Sinai Medical Center. (AP Photo/John Minchillo)

A US research team found that a pill called upadacitinib, already approved for treating rheumatoid arthritis, might also ease another common immunological condition—eczema.

In three two-phase clinical trials in the Mount Sinai Hospital, New York, around 1,700 patients with moderate to severe eczema showed rapid and significant improvements after taking the drug. The findings were published in the Lancet Journal, on May 22.

"The results of these trials were so incredible that by week 16, most patients with moderate to severe atopic dermatitis [eczema] either had a 90% disease clearance, or even 100% disease clearance," Dr. Guttman Yassky, professor and chair of the department of dermatology at Mount Sinai, said in a news release.

According to the National Eczema Association, "people with eczema tend to have an over-reactive immune system that when triggered by a substance outside or inside the body, responds by producing inflammation. It is this inflammation that causes the red, itchy and painful skin symptoms common to most types of eczema."

Eczema affects more that 31 million American adults and between 10 to 20% of children, the study authors noted. The two new clinical trials involved a total of almost 1,700 patients and took place between 2018 and 2020.

Besides the rapid disease clearance noted in patients, "the itch improvements already started to be significant within days from the beginning of the trials, and the maximum clinical efficacy was obtained early, at week 4, and maintained to week 16," Guttman Yassky said.

The drug was well tolerated by patients who received the two highest doses of the drug—15 milligrams and 30 milligrams—and no significant safety risks were seen, she added.

Upadacitinib is already approved and marketed for use against rheumatoid arthritis under the brand name Rinvoq. It works by blocking what are known as multiple cytokine-signaling pathways—parts of the immune system that can malfunction and cause eczema.



Aloha, Bavaria! Munich Surfers Riding Wild River Wave Again

Aloha, Bavaria! Munich Surfers Riding Wild River Wave Again
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Aloha, Bavaria! Munich Surfers Riding Wild River Wave Again

Aloha, Bavaria! Munich Surfers Riding Wild River Wave Again

Surfing enthusiasts have cheered the reopening of a beloved whitewater site in downtown Munich, the German city better known for partying at Oktoberfest than splashing in the waves.

The Eisbach ("ice brook") standing wave in the city's Englischer Garten park was closed after tragedy struck in April when a 33-year-old woman drowned during a nighttime winter surf.

After a safety review and a petition to keep it open, the site -- just a stone's throw from an art museum and shopping streets -- was reopened by authorities in recent weeks.

Putting on a wetsuit and taking a board out of its bag after a day's work, Moritz, 43, said he's a regular at the surf spot on an arm of the Isar river.

"It's amazing. A wave right in the city center is something very special," he said. "I missed it during the closure."

Nearby, surfers performed tricks with virtuosity on the powerful wave, formed by the presence of rocks on the riverbed near a bridge.

"It's completely different from the ocean," said Moritz.

"Even if you know how to surf very well in the sea, you don't necessarily know how to do it here where the water comes from the front and not from behind."

Another surfer, Irina, 34, said she tries to come three times a week, "before work, because it gives you energy".

She finds "the power of the wave is good" and said she feels safe at this unique spot, even if "there are rocks at the bottom and you have to be a little careful when you fall".

A German surfer lost her life during a night session in April after being trapped underwater for nearly 30 minutes, her leash caught on an unidentified object.

Friends and emergency services rushed to help her, but she died a week after her accident.

An investigation found no safety breaches on the part of the city or state, which had always warned surfers to attempt the challenge "at their own risk".

New guidelines have, however, been issued: night surfing is banned between 10:00 pm and 5:30 am, and the minimum age for braving the wave is 14.

Surfers must also use a system that allows their leash to be detached in case of emergency.

These rules are "largely reasonable", said Franz Fasel, head of the local surfers' association IGSM, who said between 3,000 and 5,000 local surfers use the Eisbach site.

"Surfing is simply part of the lifestyle in Munich," he said. "Not just for the surfers themselves, but also for the city's image."

It was not always this way. In the past, the Eisbach wave was entirely natural and surfable only occasionally, for example, when gravel accumulated in the riverbed.

Surfers took matters into their own hands in the 1980s, installing a river crossing and adding objects to improve the wave, not all well received by the authorities.

The site is now promoted by the tourist office as one of Munich's top attractions.

Bavaria's state premier Markus Soeder proudly declared during a recent visit that "Munich is a surfer's paradise" and Bavaria "a bit like the California of Germany".