Could the Omicron Variant Bring Milder Illness?

Syringes with needles are seen in front of a displayed stock graph and words "Omicron SARS-CoV-2" in this illustration taken, November 27, 2021. (Reuters)
Syringes with needles are seen in front of a displayed stock graph and words "Omicron SARS-CoV-2" in this illustration taken, November 27, 2021. (Reuters)
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Could the Omicron Variant Bring Milder Illness?

Syringes with needles are seen in front of a displayed stock graph and words "Omicron SARS-CoV-2" in this illustration taken, November 27, 2021. (Reuters)
Syringes with needles are seen in front of a displayed stock graph and words "Omicron SARS-CoV-2" in this illustration taken, November 27, 2021. (Reuters)

The Omicron variant, spreading now in southern Africa and detected in over 30 other countries, has prompted fears it could significantly undermine the effectiveness of vaccines against COVID-19.

Yet as scientists race to understand the full consequences of Omicron, some are also asking whether this new version of coronavirus might cause milder illness than its predecessors. While they caution that it is far too early to draw conclusions, here is what is known so far:

What do the data show?

Evidence from initial cases of the new variant is limited.

Among 70 cases reported in Europe that included information on disease severity, half of the patients had no symptoms and half had mild symptoms, according to a report on Thursday by the European Center for Disease Prevention and Control.

There were no cases of severe disease, hospitalization, or death. However, the European agency said it would require data on hundreds of cases to accurately assess disease complications, estimating that could take several weeks. In addition, most cases detected in Europe so far have been in younger people who were fully vaccinated, making them less likely to suffer severe illness.

In South Africa, where the daily number of reported COVID-19 cases doubled on Wednesday to 8,561, symptoms for reinfected patients and those infected after vaccination appear to be mild.

"Some evidence from South Africa suggests that it may actually cause more mild illness but ... I caution you that a lot of the patients South Africa initially were among young university students," Dr. Carlos Del Rio, an infectious diseases expert at Emory University in Atlanta, said on Thursday during an online briefing from the Infectious Diseases Society of America.

Is omicron a ‘less fit’ version of coronavirus?

While data on real world infections continues to emerge, scientists are conducting laboratory studies to decipher Omicron. The variant has about 50 mutations not seen in combination before, including more than 30 mutations on the spike protein the coronavirus uses to attach to human cells. Vaccines in current use target that spike protein.

"Typically when viruses accumulate a lot of mutations they lose some fitness," said Dr. John Wherry, director of the Penn Institute for Immunology in Philadelphia. Certain Omicron mutations may impair the ability of the virus to cleave, changing the behavior of the spike protein, he said.

Some scientists have theorized Omicron may have developed over a period of months in an immunocompromised individual, such as an HIV patient in southern Africa. If so, "the virus adapted not to kill that host," Wherry said.

There are competing theories that the latest variant evolved from an animal host.

Will omicron become the dominant variant?

The other central question surrounding Omicron is whether it will overtake the Delta variant, which still accounts for the overwhelming majority of known infections worldwide. If Omicron does become dominant, but causes milder illness, it could mark a turning point toward the virus eventually becoming a seasonal threat, like influenza, said Sumit Chanda, an infectious disease researcher at the Scripps Research Department of Immunology and Microbiology in San Diego.

The European Union's public health agency said on Thursday the Omicron variant could be responsible for more than half of all COVID-19 infections in Europe within a few months.

While the research into Omicron is underway, disease experts say people must remain vigilant against the coronavirus by getting either initial vaccinations or booster shots, as well as wearing masks in indoor or crowded settings, ventilating rooms and washing hands.



As the UN Turns 80, Its Crucial Humanitarian Aid Work Faces a Clouded Future

Students in an English class at a primary school run by URWA for Palestinian refugees at the Mar Elias refugee camp in Beirut, Lebanon, Monday, June 2, 2025. (AP Photo/Hassan Ammar)
Students in an English class at a primary school run by URWA for Palestinian refugees at the Mar Elias refugee camp in Beirut, Lebanon, Monday, June 2, 2025. (AP Photo/Hassan Ammar)
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As the UN Turns 80, Its Crucial Humanitarian Aid Work Faces a Clouded Future

Students in an English class at a primary school run by URWA for Palestinian refugees at the Mar Elias refugee camp in Beirut, Lebanon, Monday, June 2, 2025. (AP Photo/Hassan Ammar)
Students in an English class at a primary school run by URWA for Palestinian refugees at the Mar Elias refugee camp in Beirut, Lebanon, Monday, June 2, 2025. (AP Photo/Hassan Ammar)

At a refugee camp in northern Kenya, Aujene Cimanimpaye waits as a hot lunch of lentils and sorghum is ladled out for her and her nine children — all born while she has received United Nations assistance since fleeing her violence-wracked home in Congo in 2007.

“We cannot go back home because people are still being killed,” the 41-year-old said at the Kakuma camp, where the UN World Food Program and UN refugee agency help support more than 300,000 refugees, The Associated Press said.

Her family moved from Nakivale Refugee Settlement in neighboring Uganda three years ago to Kenya, now home to more than a million refugees from dozens of conflict-hit east African countries.

A few kilometers (miles) away at the Kalobeyei Refugee Settlement, fellow Congolese refugee Bahati Musaba, a mother of five, said that since 2016, “UN agencies have supported my children’s education — we get food and water and even medicine,” as well as cash support from WFP to buy food and other basics.

This year, those cash transfers — and many other UN aid activities — have stopped, threatening to upend or jeopardize millions of lives.

As the UN marks its 80th anniversary this month, its humanitarian agencies are facing one of the greatest crises in their history: The biggest funder — the United States — under the Trump administration and other Western donors have slashed international aid spending. Some want to use the money to build up national defense.

Some UN agencies are increasingly pointing fingers at one another as they battle over a shrinking pool of funding, said a diplomat from a top donor country who spoke on condition of anonymity to comment freely about the funding crisis faced by some UN agencies.

Such pressures, humanitarian groups say, diminish the pivotal role of the UN and its partners in efforts to save millions of lives — by providing tents, food and water to people fleeing unrest in places like Myanmar, Sudan, Syria and Venezuela, or helping stamp out smallpox decades ago.

“It’s the most abrupt upheaval of humanitarian work in the UN in my 40 years as a humanitarian worker, by far,” said Jan Egeland, a former UN humanitarian aid chief who now heads the Norwegian Refugee Council. “And it will make the gap between exploding needs and contributions to aid work even bigger.”

‘Brutal’ cuts to humanitarian aid programs UN Secretary-General Antonio Guterres has asked the heads of UN agencies to find ways to cut 20% of their staffs, and his office in New York has floated sweeping ideas about reform that could vastly reshape the way the United Nations doles out aid.

Humanitarian workers often face dangers and go where many others don’t — to slums to collect data on emerging viruses or drought-stricken areas to deliver water.

The UN says 2024 was the deadliest year for humanitarian personnel on record, mainly due to the war in Gaza. In February, it suspended aid operations in the stronghold of Yemen’s Houthi group, who have detained dozens of UN and other aid workers.

Proponents say UN aid operations have helped millions around the world affected by poverty, illness, conflict, hunger and other troubles.

Critics insist many operations have become bloated, replete with bureaucratic perks and a lack of accountability, and are too distant from in-the-field needs. They say postcolonial Western donations have fostered dependency and corruption, which stifles the ability of countries to develop on their own, while often UN-backed aid programs that should be time-specific instead linger for many years with no end in sight.

In the case of the Nobel Peace Prize-winning WFP and the UN’s refugee and migration agencies, the US has represented at least 40% of their total budgets, and Trump administration cuts to roughly $60 billion in US foreign assistance have hit hard. Each UN agency has been cutting thousands of jobs and revising aid spending.

“It's too brutal what has happened,” said Egeland, alluding to cuts that have jolted the global aid community. “However, it has forced us to make priorities ... what I hope is that we will be able to shift more of our resources to the front lines of humanity and have less people sitting in offices talking about the problem.”

With the UN Security Council's divisions over wars in Ukraine and the Middle East hindering its ability to prevent or end conflict in recent years, humanitarian efforts to vaccinate children against polio or shelter and feed refugees have been a bright spot of UN activity. That's dimming now.

Not just funding cuts cloud the future of UN humanitarian work

Aside from the cuts and dangers faced by humanitarian workers, political conflict has at times overshadowed or impeded their work.

UNRWA, the aid agency for Palestinian refugees, has delivered an array of services to millions — food, education, jobs and much more — in Lebanon, Syria and Jordan as well as in the West Bank and Gaza since its founding in 1948.

Israel claims the agency's schools fan antisemitic and anti-Israel sentiment, which the agency denies. Israel says Hamas siphons off UN aid in Gaza to profit from it, while UN officials insist most aid gets delivered directly to the needy.

“UNRWA is like one of the foundations of your home. If you remove it, everything falls apart,” said Issa Haj Hassan, 38, after a checkup at a small clinic at the Mar Elias Palestinian refugee camp in Beirut.

UNRWA covers his diabetes and blood pressure medication, as well as his wife’s heart medicine. The United States, Israel's top ally, has stopped contributing to UNRWA; it once provided a third of its funding. Earlier this year, Israel banned the aid group, which has strived to continue its work nonetheless.

Ibtisam Salem, a single mother of five in her 50s who shares a small one-room apartment in Beirut with relatives who sleep on the floor, said: “If it wasn’t for UNRWA we would die of starvation. ... They helped build my home, and they give me health care. My children went to their schools.”

Especially when it comes to food and hunger, needs worldwide are growing even as funding to address them shrinks.

“This year, we have estimated around 343 million acutely food insecure people,” said Carl Skau, WFP deputy executive director. “It’s a threefold increase if we compare four years ago. And this year, our funding is dropping 40%. So obviously that’s an equation that doesn’t come together easily.”

Billing itself as the world's largest humanitarian organization, WFP has announced plans to cut about a quarter of its 22,000 staff.

The aid landscape is shifting

One question is how the United Nations remains relevant as an aid provider when global cooperation is on the outs, and national self-interest and self-defense are on the upswing.

The United Nations is not alone: Many of its aid partners are feeling the pinch. Groups like GAVI, which tries to ensure fair distribution of vaccines around the world, and the Global Fund, which spends billions each year to help battle HIV, tuberculosis and malaria, have been hit by Trump administration cuts to the US Agency for International Development.

Some private-sector, government-backed groups also are cropping up, including the divisive Gaza Humanitarian Foundation, which has been providing some food to Palestinians. But violence has erupted as crowds try to reach the distribution sites.

The future of UN aid, experts say, will rest where it belongs — with the world body's 193 member countries.

“We need to take that debate back into our countries, into our capitals, because it is there that you either empower the UN to act and succeed — or you paralyze it,” said Achim Steiner, administrator of the UN Development Program.