Syria's Foreign Minister Faisal al-Mekdad arrived in Tehran on Sunday for a two-day visit at the invitation of his Iranian counterpart Hossein Amir-Abdollahian.
The visit aims to boost strategic relations between the two countries, according to Syria's al-Watan newspaper.
Deputy Foreign Minister Bashar al-Jaafari is accompanying Mekdad, who is heading an official delegation, on the trip.
The visit comes days after Damascus received an Iranian economic delegation headed by the Iranian Minister of Industry, Mine, and Trade Reza Fatemi Amin.
The delegation met several senior officials in Damascus at the opening of the exhibition of Iranian products and services in the capital.
They also launched the Syrian-Iranian Investment Forum last week, in conjunction with the announcement of a joint bank to facilitate trade and financial exchange between the two countries.
The Syrian-Iranian economic and diplomatic activity witnessed a remarkable increase, with the gradual return of Arab economic-diplomatic relations, especially from the United Arab Emirates.
Last week, Damascus hosted its first Arab economic conference since the outbreak of the Syrian conflict in 2011.
Iran's state-owned IRNA reported that the UAE's National Security Adviser, Tahnoun bin Zayed Al Nahyan, will visit Iran Monday at the invitation of the Secretary of the Supreme National Security Council Ali Shamkhani to discuss expanding bilateral ties.