Remotely Heated Seeds to Treat Brain Tumors

A tumor seen on an MRI scan. (Getty/iStock)
A tumor seen on an MRI scan. (Getty/iStock)
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Remotely Heated Seeds to Treat Brain Tumors

A tumor seen on an MRI scan. (Getty/iStock)
A tumor seen on an MRI scan. (Getty/iStock)

A tiny magnetic seed could hold the key to treating tumors in some of the most inaccessible parts of the body. According to Sky News, minimally invasive image-guided ablation, or "Minima", is a new therapy which sees the 2mm seed guided through the brain to heat and destroy tumors.

Tested on mice, it involves using an MRI scanner to navigate the seed's path to the tumor, before heating it remotely and using this heat to kill off the cancer cells. The technique could mean more effective treatment, reduced recovery times, and less chance of side effects.

It could be used against hard-to-reach glioblastoma - the most common form of brain cancer - as well as prostate cancer and other tumors that would benefit from less invasive treatment. The findings are detailed in a study published in the journal Advanced Science. Senior author, Professor Mark Lythgoe from the UCL Centre for Advanced Biomedical Imaging, told the PA news agency: "By having precise remote control of the seed using the MRI scanner, we can destroy only the cancer cells. This means that we will be able to preserve the healthy tissue.”

"In terms of neurosurgery this means that we will be able to preserve motor function and cognitive function which not only contribute to the quality of life and recovery time but can contribute to the long-term survival of the patient," he added.

Co-author Dr. Lewis Thorne is a consultant neurosurgeon at the National Hospital for Neurology and Neurosurgery who treats patients with glioblastoma.

"Minima can successfully destroy cancer in a mouse and has the potential to extend survival and limit damage to adjacent brain tissues in patients," Lythgoe added.
Professor Mark Emberton, UCL Division of Surgery and Interventional Science - lead cancer clinician in the study, said: "Improving the precision of our cancer treatments is arguably one of the greatest unmet needs we have today. "

One in eight men will be diagnosed with prostate cancer.

"While treatments such as radiotherapy and surgery can be effective, they often cause unwanted and debilitating side effects such as incontinence and impotence. Minima may allow us to precisely target and destroy prostate tumor tissue, reducing harm to normal cells,” Emberton concluded.



10 Native Spring Ephemerals that Bring Early Color to the Garden

This July 12, 2005, image provided by Bugwood.org shows dutchman's breeches (Dicentra cucullaria). (Joseph OBrien/USDA Forest Service/Bugwood.org via AP)
This July 12, 2005, image provided by Bugwood.org shows dutchman's breeches (Dicentra cucullaria). (Joseph OBrien/USDA Forest Service/Bugwood.org via AP)
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10 Native Spring Ephemerals that Bring Early Color to the Garden

This July 12, 2005, image provided by Bugwood.org shows dutchman's breeches (Dicentra cucullaria). (Joseph OBrien/USDA Forest Service/Bugwood.org via AP)
This July 12, 2005, image provided by Bugwood.org shows dutchman's breeches (Dicentra cucullaria). (Joseph OBrien/USDA Forest Service/Bugwood.org via AP)

Spring brings the return of color to the garden as bulbs bloom, perennials re-emerge, and new annuals settle in. But there’s a less common category of plants that’s also worth knowing: native spring ephemerals.

Compared to most garden plants, ephemerals are fleeting, but their role in bridging the gap between winter and spring is invaluable.

Ephemerals come to life in very early spring to take advantage of the season’s increased soil moisture, early spring rains and the availability of sunlight under leafless trees.

They poke up, grow quickly, put on a colorful show and then go dormant all within 6 to 8 weeks, typically from when the last snow melts to when the trees leaf out. And unlike plants that leave fading foliage behind, ephemerals retreat without a trace — or nearly so — allowing you to take advantage of the precious real estate left behind for later-season, shade-loving perennials, The AP news reported.

Early food for insects, and a sight for sore eyes Native ephemerals' role in nature is to feed starving insects that emerge from dormancy at a time when other food is scarce. But they also provide flowery accents for garden-starved humans at a time when landscape color is scarce.

Plant potted ephemerals or their corms or rhizomes in either spring or early fall. If sowing seeds, do so in late summer or early fall to allow time for growth and root establishment before winter. Either way, select a spot under deciduous trees that receives temporary spring sunlight and has well-draining, acidic soil (exceptions are noted below).

A generous helping of compost, mixed into the soil, will provide nutrients, and a 2-inch layer of mulch will insulate and protect roots while dormant.

Fertilizer isn’t absolutely necessary, but a dose provided when buds begin to form in spring will boost flower size.

In fall, dig up and divide overgrown ephemerals, if necessary, and give the area a good watering to help prepare them for winter. Because the plants will likely disappear underground by mid-summer, marking their spots with popsicle sticks in spring will make finding them easier.

Here are 10 native spring ephemerals to consider: Azure bluet (Houstonia caerulea) — Small, pale-blue flower with yellow center and rosette leaves. Sow seeds just below the soil surface. Grow in rock gardens or in the lawn, but don’t mow until plants have set seed for the following year. Grows 8 inches tall.

Bloodroot (Sanguinaria canadensis) — One large, broad leaf and one orange-centered white flower per plant, each on its own stem. Spreads quickly to form a ground cover. Grows 12-14 inches tall.

Calypso orchid, fairy slipper (Calypso bulbosa) — A single, dainty, purple-magenta-yellow-white blossom atop a slender stem with a single leaf. Thrives best in shade or part shade and can handle alkaline soil. Grows 2-8 inches tall.

Dutchman’s breeches (Dicentra cucullaria) — Deep-cut, feathery foliage, slender stems and drooping, fragrant white flowers. Note to parents and pet owners: All of its parts are toxic, but only if consumed in large quantities; causes minor skin irritation when touched. Beneficial to bumblebees. Grows 10 inches tall.

Fringed bleeding hearts (Dicentra eximia) — Not to be confused with the Asian bleeding heart (Lamprocapnos spectabilis), this US native has light-green, fernlike foliage and clusters of drooping, heart-shaped pink flowers on mounding plants. Thrives in moist, rocky soil and prefers part-shade to shade. Attracts birds. Grows 1-2 feet tall.

Great white trillium (Trillium grandiflorum) — A triplet of oval leaves surrounds a solitary large white flower that turns pink as it matures. Berries and roots have a low toxicity, but only if eaten. Thrives in sun to shade. Grows 1-3 feet tall.

Virginia bluebells (Mertensia virginica) — Pink, but opens to reveal blue flowers on arching, branched stems. Prefers part shade or shade, and moist, rocky soil. A colonizing, rapid spreader. Grows 1-3 feet tall.

Rue anemone (Thalictrum thalictroides) — Pink or white flowers on maroon stems with whorled leaves. Prefers partly shady conditions. Note to parents and pet owners: All parts of this plant are toxic, but only if eaten in large quantities; contact with sap will cause irritation. Grows 9 inches tall.

Trout lily (Erythronium americanum) — Blotchy leaves and red-tinged, nodding yellow flowers with curled-back petals. Will perform best in full sun but can handle part shade. Does not transplant well, so leave it in place once planted. Grows 8 inches tall.

Twinleaf (Jeffersonia diphylla) — Each leaf is divided into two lung-shaped leaflets, with white, star-shaped flowers atop leafless flower stalks. Petals are delicate and can be blown off by wind. Grows 1-3 feet tall.