AstraZeneca's Enhertu Shows Promise for Broader Breast Cancer Use

Test tubes are seen in front of a displayed AstraZeneca logo in this illustration taken, May 21, 2021. (Reuters)
Test tubes are seen in front of a displayed AstraZeneca logo in this illustration taken, May 21, 2021. (Reuters)
TT

AstraZeneca's Enhertu Shows Promise for Broader Breast Cancer Use

Test tubes are seen in front of a displayed AstraZeneca logo in this illustration taken, May 21, 2021. (Reuters)
Test tubes are seen in front of a displayed AstraZeneca logo in this illustration taken, May 21, 2021. (Reuters)

AstraZeneca said its Enhertu cancer drug has been shown to significantly help women suffering from a type of breast cancer that leaves them with poor treatment options, opening the door to a much larger potential patient group.

AstraZeneca, which is working on the drug with Japan's Daiichi Sankyo, said on Monday that Enhertu prolonged survival and slowed the progression of metastatic breast cancer with low levels of a protein known as HER2.

The improvement was "clinically meaningful" when compared with standard chemotherapy, it said, adding that detailed trial results would be presented at an as-yet undisclosed medical conference.

While the study was limited to low-HER2 patients whose tumors had spread to other parts of the body, analysts have said a positive trial read-out could portend future use at an earlier stage of the disease with potentially hundreds of thousands of new eligible patients per year.

AstraZeneca has predicted a decline in sales of its widely used COVID-19 vaccine this year.

However, brisk revenue growth from new cancer drugs has prompted analysts to rank the Anglo-Swedish company as one of the world's fastest growing major pharma groups.

Enhertu belongs to a promising class of therapies called antibody drug conjugates (ADC), which are engineered antibodies that bind to tumors cells and then release cell-killing chemicals.

AstraZeneca secured rights to the Daiichi Sankyo compound three years ago in a deal worth up to $6.9 billion, challenging the world's biggest cancer drug maker, Roche.

Enhertu has since been shown to help women with breast cancer characterized by high levels of HER2, a cell receptor that leads to uncontrolled tissue growth, when compared to Roche's ADC drug Kadcyla. This led to initial market approvals in late 2019.

Astra's drug is also being tested against gastric, lung and colorectal cancers.



As Baboons Become Bolder, Cape Town Battles for Solutions

A group of baboons move through the main shopping street of Simon's Town outside of Cape Town on October 31, 2024. (AFP)
A group of baboons move through the main shopping street of Simon's Town outside of Cape Town on October 31, 2024. (AFP)
TT

As Baboons Become Bolder, Cape Town Battles for Solutions

A group of baboons move through the main shopping street of Simon's Town outside of Cape Town on October 31, 2024. (AFP)
A group of baboons move through the main shopping street of Simon's Town outside of Cape Town on October 31, 2024. (AFP)

On a sunny afternoon in Cape Town's seaside village of Simon's Town, three young chacma baboons cause a commotion, clambering on roofs, jumping between buildings and swinging on the gutters.

Enchanted tourists stop to photograph the troop crossing the road. Locals are less impressed: it's a daily scene in the charming village nestled between the Atlantic Ocean and Table Mountain National Park.

About 500 chacma baboons -- among the largest monkey species and weighing up to 40 kilos (88 pounds) -- roam the peninsula south of Cape Town, says the South African National Biodiversity Institute.

And as human development pushes up the mountain into their natural habitat, the animals are increasingly entering plush properties to forage in gardens and take the pickings from the bins. Some manage to sneak into houses where they can wreak havoc.

Many locals are fond of the creatures, giving them pet names and following their daily adventures on social media.

But others are increasingly frustrated.

"They've become so bold now. They're more domesticated than they should be," said Duncan Low, 60, who runs an ice cream shop.

The intruders have even started raiding kitchens and grabbing food from plates in restaurants. "They're on a sugar and fast-food rush," Low said.

In 2021, the city put down a notorious alpha-male monkey who had terrorized residents with more than 40 raids for food in rubbish bins, from lawns and porches, sometimes entering homes while people were inside.

- Monkey management -

Tension between humans and baboons is "the highest it's ever been", said ecologist Justin O'Riain, who directs the Institute for Communities and Wildlife in Africa at the University of Cape Town.

A baboon on the edge of a wild and an urban area is "the most difficult animal in the world to manage", O'Riain said.

"They are strong, they can climb... and they can learn from each other: there's no landscape that they can't conquer."

As human settlement of the Cape has expanded, the baboons have been "pushed higher and higher up the mountain" where foraging conditions are harder, O'Riain added.

The lush gardens that people have built, with fruit trees and swimming pools, are tempting attractions.

The City of Cape Town, in partnership with park authorities, has for years run a program to manage the marauding monkeys that relies on teams of baboon monitors.

They employ a primarily non-lethal approach, O'Riain said.

However, some techniques, such as firing paintball guns to keep troops away or culling a particularly problematic animal, have come under fire.

Amid an increasingly emotional outcry, vociferous campaigner Baboon Matters announced court action against the city and parks authorities in May for failing to implement what it considers more acceptable control measures, such as baboon-proof fencing and bins.

Facing criticism and funding limits, the authorities said the baboon management program would be wound down by the end of the year as they investigate other "more sustainable urban solutions".

It will however remain in place through December -- a particularly busy month for tourists -- but with fewer rangers, it said.

"We're going to lose our first line of defense," O'Riain said, with more baboons already entering urban areas often at risk to their lives.

- Deaths highest in 10 years -

Thirty-three baboons were known to have died between July 2023 and June 2024, the highest number in 10 years, city authorities say.

Nearly half the deaths were caused by human factors, including shooting with pellet guns, collisions with vehicles and dog attacks.

Coexistence with baboons should come with "a degree of human compliance", starting with managing food waste, conservation activist Lynda Silk, head of the Cape Peninsula Civil Conservation group, said.

"We don't need to be in competition with our natural resources: there can be ways that we can manage our lifestyles to minimize the negative impacts," she said.

For O'Riain, the only viable solution to the baboon battle is to erect fencing in certain areas that is made up of electric wiring and underground mesh to prevent the animals from digging underneath.

A prototype installed 11 years ago had shown great success, with almost no animals entering the area, he said. A 2023 report already suggested where the fencing should be placed.

"Baboons can come and forage right up to the edge of the fence and no one will disturb them," said O'Riain.

"It's a completely peaceful interaction, a win-win for people and for baboons."