GSK Halts 3 Trials of Respiratory Virus Vaccine in Pregnant Women

GSK logo is displayed in this illustration taken January 17, 2022. (Reuters)
GSK logo is displayed in this illustration taken January 17, 2022. (Reuters)
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GSK Halts 3 Trials of Respiratory Virus Vaccine in Pregnant Women

GSK logo is displayed in this illustration taken January 17, 2022. (Reuters)
GSK logo is displayed in this illustration taken January 17, 2022. (Reuters)

Britain's GSK said on Monday it had halted enrollment and vaccination in three trials of its experimental vaccine against the respiratory syncytial virus (RSV) in pregnant women, the latest setback in developing a vaccine for the microbe.

GSK said on Feb. 18 that it had paused a late-stage trial, dubbed "GRACE," as well as two other studies, based on safety recommendations from an independent committee but did not give further details on what had prompted the recommendations.

RSV is a leading cause of pneumonia in toddlers and the elderly, but vaccine development has been plagued by setbacks for decades. However, many drugmakers are now working to bring a candidate to the market over the next few years.

GSK, the world's biggest vaccine maker by sales, reiterated on Monday that the halts did not affect another trial of its RSV vaccine candidate for adults aged 60 and over, adding that analysis of the safety data from the maternal trials is ongoing.

RSV vaccines are seen as an opportunity for GSK to deliver on pledges to boost its drug development success rate, where it has long lagged industry peers. GSK's shot for pregnant women was aimed at conferring immunity to protect unborn children.

Its vaccine for the elderly, another major vulnerable population, has been regarded by analysts as a potential big RSV market, with trial results expected in the first half this year.



Scientists Drill Nearly 2 Miles Down to Pull 1.2 Million-year-old Ice Core from Antarctic

An international team of scientists announced successfully drilled one of the oldest ice cores yet - The AP
An international team of scientists announced successfully drilled one of the oldest ice cores yet - The AP
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Scientists Drill Nearly 2 Miles Down to Pull 1.2 Million-year-old Ice Core from Antarctic

An international team of scientists announced successfully drilled one of the oldest ice cores yet - The AP
An international team of scientists announced successfully drilled one of the oldest ice cores yet - The AP

An international team of scientists announced Thursday they’ve successfully drilled one of the oldest ice cores yet, penetrating nearly 2 miles (2.8 kilometers) to Antarctic bedrock to reach ice they say is at least 1.2 million years old.

Analysis of the ancient ice is expected to show how Earth's atmosphere and climate have evolved. That should provide insight into how Ice Age cycles have changed, and may help in understanding how atmospheric carbon changed climate, they said, The AP reported.

“Thanks to the ice core we will understand what has changed in terms of greenhouse gases, chemicals and dusts in the atmosphere,” said Carlo Barbante, an Italian glaciologist and coordinator of Beyond EPICA, the project to obtain the core. Barbante also directs the Polar Science Institute at Italy's National Research Council.

The same team previously drilled a core about 800,000 years old. The latest drilling went 2.8 kilometers (about 1.7 miles) deep, with a team of 16 scientists and support personnel drilling each summer over four years in average temperatures of about minus-35 Celsius (minus-25.6 Fahrenheit).

Italian researcher Federico Scoto was among the glaciologists and technicians who completed the drilling at the beginning of January at a location called Little Dome C, near Concordia Research Station.

“It was a great a moment for us when we reached the bedrock,” Scoto said. Isotope analysis gave the ice's age as at least 1.2 million years old, he said.

Both Barbante and Scoto said that thanks to the analysis of the ice core of the previous Epica campaign they have assessed that concentrations of greenhouse gases, such as carbon dioxide and methane, even during the warmest periods of the last 800,000 years, have never exceeded the levels seen since the Industrial Revolution began.

“Today we are seeing carbon dioxide levels that are 50% above the highest levels we’ve had over the last 800,000 years," Barbante said.

The European Union funded Beyond EPICA (European Project for Ice Coring in Antarctica) with support from nations across the continent. Italy is coordinating the project.

The announcement was exciting to Richard Alley, a climate scientist at Penn State who was not involved with the project and who was recently awarded the National Medal of Science for his career studying ice sheets.

Alley said advancements in studying ice cores are important because they help scientists better understand the climate conditions of the past and inform their understanding of humans’ contributions to climate change in the present. He added that reaching the bedrock holds added promise because scientists may learn more about Earth’s history not directly related to the ice record itself.

“This is truly, truly, amazingly fantastic,” Alley said. “They will learn wonderful things.”