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Key to Alzheimer’s Lies in Gut Not Brain, Says New Study

This undated image courtesy of, Dr. Timothy Rittman, University of Cambridge, shows an MRI image of a healthy brain (L) and an Alzheimer's brain (R) with large black gaps where brain has shrunk. (AFP)
This undated image courtesy of, Dr. Timothy Rittman, University of Cambridge, shows an MRI image of a healthy brain (L) and an Alzheimer's brain (R) with large black gaps where brain has shrunk. (AFP)
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Key to Alzheimer’s Lies in Gut Not Brain, Says New Study

This undated image courtesy of, Dr. Timothy Rittman, University of Cambridge, shows an MRI image of a healthy brain (L) and an Alzheimer's brain (R) with large black gaps where brain has shrunk. (AFP)
This undated image courtesy of, Dr. Timothy Rittman, University of Cambridge, shows an MRI image of a healthy brain (L) and an Alzheimer's brain (R) with large black gaps where brain has shrunk. (AFP)

The key to stopping dementia could lie in the gut rather than the brain, new research suggests. Decades of studies from around the world costing billions of pounds have so far failed to uncover a way of tackling the memory-robbing disease. But the gut “represents an alternative target that may be easier to influence with drugs or diet changes”, experts have said.

A series of experiments linking the gut to the development of Alzheimer's were presented at the Alzheimer's Research UK 2022 Conference in Brighton on March 1, The Daily Mail reported.

One revealed how the microbiomes — the community of bacteria in the gut — of patients with the condition can differ massively to those without the disorder.

Another found rodents given fecal transplants directly from Alzheimer's patients perform worse on memory tests. A third study saw brain stem cells treated with blood from patients with the disorder were less able to grow new nerve cells.

In theory, the patients' gut bacteria influence the levels of inflammation in the body which then impacts the brain via the blood supply. Inflammation is considered a key contributor to the development of Alzheimer's. The disease is the most common type of dementia, and one of the leading causes of death in the UK.

Charities estimate roughly 900,000 people in Britain and 5million in the US are living with the disorder, with that number growing every year as we live longer.

Dr. Edina Silajdžić, a neuroscientist from King's College London, involved in the analysis of samples from Alzheimer's patients, said: “Most people are surprised that their gut bacteria could have any bearing on the health of their brain. But the evidence is mounting — and we are building an understanding of how this comes about.”

“This leads us to believe inflammation associated with gut bacteria can affect the brain via the blood,” Silajdžić noted.

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Animals Found Living Underground Near Deep-sea Hydrothermal Vents

Giant tubeworms on the seafloor surface at 2,500 meters water depth at the East Pacific Rise, a volcanically active ridge located where two tectonic plates meet on the floor of the Pacific Ocean in this undated photograph.CC BY-NC-SA Schmidt Ocean Institute/Handout via REUTERS
Giant tubeworms on the seafloor surface at 2,500 meters water depth at the East Pacific Rise, a volcanically active ridge located where two tectonic plates meet on the floor of the Pacific Ocean in this undated photograph.CC BY-NC-SA Schmidt Ocean Institute/Handout via REUTERS
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Animals Found Living Underground Near Deep-sea Hydrothermal Vents

Giant tubeworms on the seafloor surface at 2,500 meters water depth at the East Pacific Rise, a volcanically active ridge located where two tectonic plates meet on the floor of the Pacific Ocean in this undated photograph.CC BY-NC-SA Schmidt Ocean Institute/Handout via REUTERS
Giant tubeworms on the seafloor surface at 2,500 meters water depth at the East Pacific Rise, a volcanically active ridge located where two tectonic plates meet on the floor of the Pacific Ocean in this undated photograph.CC BY-NC-SA Schmidt Ocean Institute/Handout via REUTERS

A deep-diving robot that chiseled into the rocky Pacific seabed at a spot where two of the immense plates comprising Earth's outer shell meet has unearthed a previously unknown realm of animal life thriving underground near hydrothermal vents.

Giant tubeworms - the world's heftiest worms - and other marine invertebrates such as snails and bristle worms were found using the remotely operated underwater vehicle SuBastian. They were living inside cavities within the Earth's crust at an ocean-floor site where the Pacific is 1.56 miles (2,515 meters) deep. All the species were previously known to have lived near such vents, but never underground, Reuters reported.

"We discovered vent animal life in the cavities of the ocean's crust. We now know that the unique hydrothermal vent ecosystem extends into the ocean's crust," said marine biologist Sabine Gollner of the Royal Netherlands Institute for Sea Research, one of the leaders of the study published this week in the journal Nature Communications.

"To our knowledge, it is the first time that animal life has been discovered in the ocean crust," Gollner added.

The exploration was conducted at the East Pacific Rise, a volcanically active ridge on the floor of the southeastern Pacific, running approximately parallel to South America's west coast. Earth's rigid outer part is divided into colossal plates that move gradually over time in a process called plate tectonics. The East Pacific Rise is located where two such plates are gradually spreading apart.

This area contains many hydrothermal vents, fissures in the seafloor situated where seawater and magma beneath the Earth's crust come together. Magma refers to molten rock that is underground, while lava refers to molten rock that reaches the surface, including the seafloor. New seafloor forms in places where magma is forced upward toward the surface at a mid-ocean ridge and cools to form volcanic rock.

The hydrothermal vents spew into the cold sea the super-heated and chemical-rich water that nourishes microorganisms.

"The warm venting fluids are rich in energy - for example, sulfide - that can be used by microbes, which form the basis of the food-chain," Gollner said.

Life flourishes around the vents - including giant tubeworms reaching lengths of 10 feet (3 meters), mussels, crabs, shrimp, fish and other organisms beautifully adapted to this extreme environment. The giant tubeworms do not eat as other animals do. Instead, bacteria residing in their body in a sack-like organ turn sulfur from the water into energy for the animal.

The researchers deployed SuBastian from the Schmidt Ocean Institute research vessel Falkortoo to the vent site deep below. The robot was equipped with arms that wielded a chisel that the researchers used to dig into the crust and uncover warm and fluid-filled cavities where the tubeworms, bristle worms and snails were spotted.

"We used a chisel to break the rock. We dug about 20 cm (8 inches). The lava plates were about 10 cm (4 inches) thick. The cavities below the lava plates were about 10 cm in height," Gollner said.

Larvae from these animals may invade these subseafloor habitats, the researchers said, in an example of connectivity between the seafloor and underground ecosystems.

"It changed our view on connectedness in the ocean," Gollner said of discovering the subsurface lair.