‘Spider Silk’ Could be Used to Treat Cancer, New Study Suggests

Drops of water are seen on a spider's web during harvest at
Chateau du Pavillon in Sainte-Croix-Du-Mont vineyard, France, October
22, 2018. REUTERS/Regis Duvignau/File Photo
Drops of water are seen on a spider's web during harvest at Chateau du Pavillon in Sainte-Croix-Du-Mont vineyard, France, October 22, 2018. REUTERS/Regis Duvignau/File Photo
TT

‘Spider Silk’ Could be Used to Treat Cancer, New Study Suggests

Drops of water are seen on a spider's web during harvest at
Chateau du Pavillon in Sainte-Croix-Du-Mont vineyard, France, October
22, 2018. REUTERS/Regis Duvignau/File Photo
Drops of water are seen on a spider's web during harvest at Chateau du Pavillon in Sainte-Croix-Du-Mont vineyard, France, October 22, 2018. REUTERS/Regis Duvignau/File Photo

A research team from the Karolinska Institutet, Sweden, used spider silk to address a problem that challenged researchers for years: the inability to benefit from a key weapon in their fight against cancer, the protein p53.

The p53 protein protects our cells from cancer and is an interesting target for cancer treatments. The problem is, however, that it breaks down rapidly in the cell. Researchers at Karolinska Institutet in Sweden have now found an unusual way of stabilizing the protein and making it more potent. By adding a spider silk protein to p53, they show that it is possible to create a protein that is more stable and capable of killing cancer cells.

The study is published in the journal Structure. P53 plays a key role in the body's defense against cancer, in part by discovering and preventing genetic mutations that can lead to cancer. If a cell is lacking functional p53, it quickly becomes a cancer cell that starts to divide uncontrollably.

Researchers around the world are therefore trying to develop cancer treatments that in some way target p53.

"The problem is that cells only make small amounts of p53 and then quickly break it down as it is a very large and disordered protein. We've been inspired by how nature creates stable proteins and have used spider silk protein to stabilize p53. Spider silk consists of long chains of highly stable proteins and is one of nature's strongest polymers,” says Michael Landreh, researcher at the Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet.

During the study, the researchers attached a small section of a synthetic spider silk protein onto the human p53 protein. When they then introduced it into cells, they found that the cells started to produce it in large quantities.

The new protein also proved to be more stable than ordinary p53 and capable of killing cancer cells. Using electron microscopy, computer simulations, and mass spectrometry, they were able to show that the likely reason for this was the way the spider silk part managed to give structure to p53's disordered sections.



The Next Round of Bitter Cold and Snow will Hit the Southern US

A person holds an umbrella as they walk during a winter storm, Monday, Jan. 6, 2025, in Cincinnati. (AP Photo/Joshua A. Bickel)
A person holds an umbrella as they walk during a winter storm, Monday, Jan. 6, 2025, in Cincinnati. (AP Photo/Joshua A. Bickel)
TT

The Next Round of Bitter Cold and Snow will Hit the Southern US

A person holds an umbrella as they walk during a winter storm, Monday, Jan. 6, 2025, in Cincinnati. (AP Photo/Joshua A. Bickel)
A person holds an umbrella as they walk during a winter storm, Monday, Jan. 6, 2025, in Cincinnati. (AP Photo/Joshua A. Bickel)

The next round of bitter cold was set to envelop the southern U.S. on Tuesday, after the first significant winter storm of the year blasted a huge swath of the country with ice, snow and wind.

The immense storm system brought disruption even to areas of the country that usually escape winter’s wrath, downing trees in some Southern states, threatening a freeze in Florida and causing people in Dallas to dig deep into their wardrobes for hats and gloves.

By early Tuesday, wind chill temperatures could dip into the teens to low 20s (as low as minus 10.5 C) from Texas across the Gulf Coast, according to the National Weather Service. A low-pressure system is then expected to form as soon as Wednesday near south Texas, bringing the potential of snow to parts of the state that include Dallas, as well as to Oklahoma, Arkansas and Louisiana.

The polar vortex that dipped south over the weekend kept much of the country east of the Rockies in its frigid grip Monday, making many roads treacherous, forcing school closures, and causing widespread power outages and flight cancellations.

Ice and snow blanketed major roads in Kansas, western Nebraska and parts of Indiana, where the National Guard was activated to help stranded motorists. The National Weather Service issued winter storm warnings for Kansas and Missouri, where blizzard conditions brought wind gusts of up to 45 mph (72 kph). The warnings extended to New Jersey into early Tuesday.

A Kentucky truck stop was jammed with big rigs forced off an icy and snow-covered Interstate 75 on Monday just outside Cincinnati. A long haul driver from Los Angeles carrying a load of rugs to Georgia, Michael Taylor said he saw numerous cars and trucks stuck in ditches and was dealing with icy windshield wipers before he pulled off the interstate.

“It was too dangerous. I didn’t want to kill myself or anyone else,” he said.

The polar vortex of ultra-cold air usually spins around the North Pole, but it sometimes plunges south into the U.S., Europe and Asia. Studies show that a fast-warming Arctic is partly to blame for the increasing frequency of the polar vortex extending its grip.

Temperatures plunge across the country The eastern two-thirds of the U.S. dealt with bone-chilling cold and wind chills Monday, with temperatures in some areas far below normal.

A cold weather advisory will take effect early Tuesday across the Gulf Coast. In Texas’ capital of Austin and surrounding cities, wind chills could drop as low as 15 degrees (minus 9.4 C).

The Northeast was expected to get several cold days.

Transportation has been tricky Hundreds of car accidents were reported in Virginia, Indiana, Kansas and Kentucky, where a state trooper was treated for non-life-threatening injuries after his patrol car was hit.

Virginia State Police responded to at least 430 crashes Sunday and Monday, including one that was fatal. Police said other weather-related fatal accidents occurred Sunday near Charleston, West Virginia, and Monday in Winston-Salem, North Carolina. Kansas saw two deadly crashes over the weekend, The AP reported.

More than 2,300 flights were canceled and at least 9,100 more were delayed nationwide as of Monday night, according to tracking platform FlightAware. Ronald Reagan Washington National Airport reported that about 58% of arrivals and 70% of departures had been canceled.

A record 8 inches (more than 20 centimeters) of snow fell Sunday at the Cincinnati/Northern Kentucky International Airport, leading to dozens of flight cancellations that lingered into Monday. About 4 inches (about 10 centimeters) fell Monday across the Cincinnati area, where car and truck crashes shut at least two major routes leading into downtown.

More snow and ice are expected In Indiana, snow covered stretches of Interstate 64, Interstate 69 and U.S. Route 41, leading authorities to plead with people to stay home.

“It’s snowing so hard, the snow plows go through and then within a half hour the roadways are completely covered again,” State Police Sgt. Todd Ringle said.

The Mid-Atlantic region had been forecast to get another 6 to 12 inches (15 to 30 centimeters) of snow on Monday. Dangerously cold temperatures were expected to follow, with nighttime lows falling into the single digits (below minus 12.7 C) through the middle of the week across the Central Plains and into the Mississippi and Ohio valleys.

In North Texas, 2 to 5 inches (about 5 to 13 centimeters) of snow was expected beginning Thursday, according to the National Weather Service. Snow could also hit Oklahoma and Arkansas, with some parts potentially getting more than 4 inches (about 10 centimeters).

Classes canceled in several states School closings were widespread, with districts in Indiana, Virginia, Kentucky, Missouri and Kansas canceling or delaying the start of classes Monday. Among them was Kentucky’s Jefferson County Public Schools, which canceled classes and other school activities for its nearly 100,000 students.

Classes were also canceled in Maryland, where Gov. Wes Moore declared a state of emergency Sunday and announced that state government offices would also be closed Monday. Government offices also were closed Monday in Kentucky, where Gov. Andy Beshear declared a state of emergency.

Tens of thousands are without power Many were in the dark as temperatures plunged. More than 218,000 customers were without power Monday night across Kentucky, Indiana, Virginia, West Virginia, Illinois, Missouri and North Carolina, according to electric utility tracking website PowerOutage.us.

In Virginia’s capital city, a power outage caused a temporary malfunction in the water system, officials said Monday afternoon. Richmond officials asked those in the city of more than 200,000 people to refrain from drinking tap water or washing dishes without boiling the water first. The city also asked people to conserve their water, such as by taking shorter showers.

City officials said they were working nonstop to bring the system back online.