‘Spider Silk’ Could be Used to Treat Cancer, New Study Suggests

Drops of water are seen on a spider's web during harvest at
Chateau du Pavillon in Sainte-Croix-Du-Mont vineyard, France, October
22, 2018. REUTERS/Regis Duvignau/File Photo
Drops of water are seen on a spider's web during harvest at Chateau du Pavillon in Sainte-Croix-Du-Mont vineyard, France, October 22, 2018. REUTERS/Regis Duvignau/File Photo
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‘Spider Silk’ Could be Used to Treat Cancer, New Study Suggests

Drops of water are seen on a spider's web during harvest at
Chateau du Pavillon in Sainte-Croix-Du-Mont vineyard, France, October
22, 2018. REUTERS/Regis Duvignau/File Photo
Drops of water are seen on a spider's web during harvest at Chateau du Pavillon in Sainte-Croix-Du-Mont vineyard, France, October 22, 2018. REUTERS/Regis Duvignau/File Photo

A research team from the Karolinska Institutet, Sweden, used spider silk to address a problem that challenged researchers for years: the inability to benefit from a key weapon in their fight against cancer, the protein p53.

The p53 protein protects our cells from cancer and is an interesting target for cancer treatments. The problem is, however, that it breaks down rapidly in the cell. Researchers at Karolinska Institutet in Sweden have now found an unusual way of stabilizing the protein and making it more potent. By adding a spider silk protein to p53, they show that it is possible to create a protein that is more stable and capable of killing cancer cells.

The study is published in the journal Structure. P53 plays a key role in the body's defense against cancer, in part by discovering and preventing genetic mutations that can lead to cancer. If a cell is lacking functional p53, it quickly becomes a cancer cell that starts to divide uncontrollably.

Researchers around the world are therefore trying to develop cancer treatments that in some way target p53.

"The problem is that cells only make small amounts of p53 and then quickly break it down as it is a very large and disordered protein. We've been inspired by how nature creates stable proteins and have used spider silk protein to stabilize p53. Spider silk consists of long chains of highly stable proteins and is one of nature's strongest polymers,” says Michael Landreh, researcher at the Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet.

During the study, the researchers attached a small section of a synthetic spider silk protein onto the human p53 protein. When they then introduced it into cells, they found that the cells started to produce it in large quantities.

The new protein also proved to be more stable than ordinary p53 and capable of killing cancer cells. Using electron microscopy, computer simulations, and mass spectrometry, they were able to show that the likely reason for this was the way the spider silk part managed to give structure to p53's disordered sections.



Wildfires Rage in Los Angeles, Forcing Tens of Thousands to Flee

 Firefighters battle the Palisades Fire in the Pacific Palisades neighborhood of Los Angeles, Tuesday, Jan. 7, 2025. (AP)
Firefighters battle the Palisades Fire in the Pacific Palisades neighborhood of Los Angeles, Tuesday, Jan. 7, 2025. (AP)
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Wildfires Rage in Los Angeles, Forcing Tens of Thousands to Flee

 Firefighters battle the Palisades Fire in the Pacific Palisades neighborhood of Los Angeles, Tuesday, Jan. 7, 2025. (AP)
Firefighters battle the Palisades Fire in the Pacific Palisades neighborhood of Los Angeles, Tuesday, Jan. 7, 2025. (AP)

A rapidly growing wildfire raged across an upscale section of Los Angeles on Tuesday, destroying numerous buildings and creating traffic jams as more than 30,000 people evacuated, while a second blaze doubled in size some 30 miles inland.

At least 2,921 acres (1,182 hectares) of the Pacific Palisades area between the coastal towns of Santa Monica and Malibu had burned by the Palisades Fire, officials said, after they had already warned of extreme fire danger from powerful winds that arrived following extended dry weather.

A fire official told local television station KTLA that several people were injured, some with burns to faces and hands. The official added that one female firefighter had sustained a head injury.

The second blaze dubbed the Eaton Fire broke out some 30 miles (50 km) inland near Pasadena and doubled in size to 400 acres (162 hectares) in a few hours, according to Cal Fire.

Almost 100 residents from a nursing home in Pasadena were evacuated, according to CBS News. Video showed elderly residents, many in wheelchairs and on gurneys, crowded onto a smokey and windswept parking lot as fire trucks and ambulances attended.

Fire officials said a third blaze named the Hurst Fire had started in Sylmar, in the San Fernando Valley northwest of Los Angeles, prompting evacuations of some nearby residents.

PALISADES FIRE

Witnesses reported a number of homes on fire with flames nearly scorching their cars when people fled the hills of Topanga Canyon, as the fire spread from there down to the Pacific Ocean.

Local media reported the fire had spread north, torching homes near Malibu.

Los Angeles Fire Chief Kristin Crowley had earlier told a press conference that more than 25,000 people in 10,000 homes were threatened.

Firefighters in aircraft scooped water from the sea to drop it on the nearby flames. Flames engulfed homes and bulldozers cleared abandoned vehicles from roads so emergency vehicles could pass, television images showed.

The fire singed some trees on the grounds of the Getty Villa, a museum loaded with priceless works of art, but the collection remained safe largely because of preventive efforts to trim brush surrounding the buildings, the museum said.

With only one major road leading from the canyon to the coast, and only one coastal highway leading to safety, traffic crawled to a halt, leading people to flee on foot.

Cindy Festa, a Pacific Palisades resident, said that as she evacuated out of the canyon, fires were "this close to the cars," demonstrating with her thumb and forefinger.

"People left their cars on Palisades Drive. Burning up the hillside. The palm trees - everything is going," Festa said from her car.

Before the fire started, the National Weather Service had issued its highest alert for extreme fire conditions for much of Los Angeles County from Tuesday through Thursday, predicting wind gusts of 50 to 80 mph (80 to 130 kph).

With low humidity and dry vegetation due to a lack of rain, the conditions were "about as bad as it gets in terms of fire weather," the Los Angeles office of the National Weather Service said on X.

Governor Gavin Newsom, who declared a state of emergency, said the state positioned personnel, firetrucks and aircraft elsewhere in Southern California because of the fire danger to the wider region, he added.

The powerful winds changed President Joe Biden's travel plans, grounding Air Force One in Los Angeles. He had planned to make a short flight inland to the Coachella Valley for a ceremony to create two new national monuments in California but the event was rescheduled for a later date at the White House.

"I have offered any federal assistance that is needed to help suppress the terrible Pacific Palisades fire," Biden said in a statement. A federal grant had already been approved to help reimburse the state of California for its fire response, Biden said.

Pacific Palisades is home to several Hollywood stars. Actor James Woods said on X he was able to evacuate but added, "I do not know at this moment if our home is still standing."

Actor Steve Guttenberg told KTLA television that friends of his were impeded from evacuating because others had abandoned their cars on the road.

"It's really important for everybody to band together and don't worry about your personal property. Just get out," Guttenberg said. "Get your loved ones and get out."