Houthi Restrictions Hinder UN Efforts to Study Food Security in Yemen

Yemenis in Amran governorate, north of Sanaa, waiting to receive food aid (EPA)
Yemenis in Amran governorate, north of Sanaa, waiting to receive food aid (EPA)
TT

Houthi Restrictions Hinder UN Efforts to Study Food Security in Yemen

Yemenis in Amran governorate, north of Sanaa, waiting to receive food aid (EPA)
Yemenis in Amran governorate, north of Sanaa, waiting to receive food aid (EPA)

The United Nations Office for the Coordination of Humanitarian Affairs (OCHA) was unable to assess the food situation of Yemenis living under Houthi control because of restrictions imposed by the Iran-backed group.

OCHA, however, noted that its new analysis on food security showed that the number of aid beneficiaries during the last three months of this year increased to four times the estimated figure in previous outlooks.

The UN body added that two Houthi-run areas are facing the threat of famine.

Weeks after the UN affirmed that the majority of the obstacles encountered by the humanitarian work teams come from Houthis authorities, OCHA stated that the phased classification of food security was updated in 125 districts in the governorates controlled by the internationally recognized government.

OCHA officials have recommended the adoption of hypothetical analyzes for areas controlled by the Houthis.

They pointed out that the analysis that was conducted last February in 208 districts in Houthi-run areas was not updated. Moreover, the officials revised initial assumptions from the previous analysis.

Conclusions by the officials included sudden shocks and other contributing factors such as food prices and floods. These factors were not factored in during the previous analysis.

UN analysis indicated that the number of cases estimated in the previous report suggests that approximately 2.2 million children under the age of five suffer from malnutrition, including 538,000 suffering from acute malnutrition.

Meanwhile, the report predicted that about 1.3 million pregnant and breastfeeding women would suffer from malnutrition.

The analysis update indicated an increased risk.

It pointed to the situation changing in 17 districts and reaching a worse stage compared to last February’s expectations.

In Al-Mahra Governorate, nine regions are under the threat of a crisis. Eight neighborhoods in the city of Aden will move from the crisis stage to the emergency stage.



Palestinian President’s Advisor: Board of Peace, Related Entities Are a ‘Temporary Arrangement’

Palestinian President Mahmoud Abbas’ advisor Dr. Mahmoud Al-Habbash. WAFA
Palestinian President Mahmoud Abbas’ advisor Dr. Mahmoud Al-Habbash. WAFA
TT

Palestinian President’s Advisor: Board of Peace, Related Entities Are a ‘Temporary Arrangement’

Palestinian President Mahmoud Abbas’ advisor Dr. Mahmoud Al-Habbash. WAFA
Palestinian President Mahmoud Abbas’ advisor Dr. Mahmoud Al-Habbash. WAFA

Palestinian President Mahmoud Abbas’ advisor Dr. Mahmoud Al-Habbash said that the situation in the Gaza Strip, along with the formation of the Board of Peace and its related entities is not a Palestinian choice.

This is “a temporary arrangement (mandated by the UN Security Council) that the Palestinian leadership rejects under any circumstances... but it is the lesser of two evils,” Al-Habbash told Asharq Al-Awsat.

Speaking from Ramallah, Al-Habbash said that the Palestinian leadership “chose this arrangement to stop the massacre and open a potential window ... leading to a Palestinian state.”

US President Donald Trump announced last week the formation of the Board of Peace, a new body of world leaders meant to oversee next steps in Gaza.

The White House said there would be a main board, chaired by Trump himself, a Palestinian committee of technocrats meant to govern the war-wracked territory, and a second "executive board" that appears designed to have a more advisory role.

“Our clear and firm position is that we did not create this reality,” said Al-Habbash. “Rather, it is a reality imposed on us for two reasons: First, Israel’s aggression ... and second, the reckless adventure carried out by Hamas movement, which whetted Israel’s appetite to liquidate the Palestinian cause.”

According to Al-Habbash, “this transitional arrangement is the least harmful to the Palestinian cause,” because it ensures that Palestinians remain in the Gaza Strip and prevents displacement.


Innovative Drug Lowers Triglycerides, Other Blood Lipids

High levels of triglycerides in the blood increase the risk of heart disease (Monash University) 
High levels of triglycerides in the blood increase the risk of heart disease (Monash University) 
TT

Innovative Drug Lowers Triglycerides, Other Blood Lipids

High levels of triglycerides in the blood increase the risk of heart disease (Monash University) 
High levels of triglycerides in the blood increase the risk of heart disease (Monash University) 

A study led by researchers from the Ecole Polytechnique Fédérale de Lausanne (EPFL) in Switzerland, revealed a new liver- and gut-targeted oral drug that can safely lower triglycerides and other blood lipids.

Researchers of the study, published last Friday in Nature Medicine, said the innovative drug could represent a breakthrough in treating metabolic diseases related to high triglycerides in the body.

The study said that when we eat, our bodies convert extra calories, especially from carbs, sugar, fats, and alcohol, into molecules called “triglycerides.”

Triglycerides are a form of fat or “lipid,” which the body stores away into its fat cells as an energy fuel for energy between meals.

But, excess amounts of fat in the body can be dangerous, causing a condition known as “hypertriglyceridemia” (“excess triglycerides in the blood”), which significantly increases the risk of heart disease, stroke, and pancreatitis.

This is why we are universally advised to make healthy lifestyle choices in diet, exercise, while particularly bad cases require medication.

The study also found that keeping blood fats in check depends on a careful balance.

It said the liver and intestine release fat particles into the bloodstream, while enzymes work to break them down and clear them away.

When fat production outpaces clearance, triglycerides build up, setting the stage for metabolic diseases like dyslipidemia, acute pancreatitis, and metabolic dysfunction-associated steatotic liver disease (MASLD).

One of the master switches in this system is a protein called Liver X Receptor, or LXR, which controls several genes that are involved in making and handling fats.

When LXR is active, triglycerides and cholesterol tend to rise.

Therefore, dialing it down through medication seems promising, but as LXR is also involved in protective cholesterol pathways elsewhere in the body, blocking it everywhere could do more harm than good.

Now, scientists have addressed this problem with an orally administered compound that can repress the activity of LXR specifically in the liver and gut to lower triglycerides without disrupting the body’s protective cholesterol pathways.

The compound, TLC‑2716, is what is known as an “inverse agonist” for the LXR. Unlike a “blocker” (“antagonist”) that merely stops a receptor from being activated, an “inverse agonist” makes the receptor signal the opposite effect to what it would normally do.

Clinical Trial

The lab findings set the stage for a randomized, placebo-controlled Phase 1 study in healthy adults. Participants received TLC‑2716 for 14 days given as a single dose per day and the trial focused first on safety and tolerability, and the authors report that the drug met these primary endpoints.

But even this short trial had clear effects: participants who received higher doses of TLC‑2716 showed notable drops in triglycerides as well as remnant cholesterol.

At the highest doses of TLC‑2716 (12mg), triglycerides fell by up to 38.5%, while postprandial (“after eating”) remnant cholesterol dropped by as much as 61%.

This happened despite participants starting with relatively normal lipid levels and without the use of other lipid-lowering drugs, the study showed.

Also, the treatment sped up triglyceride clearance by reducing the activity of two proteins that normally slow it down, ApoC3 and ANGPTL3.

At the same time, the study did not detect reductions in blood-cell expression of ABCA1 and ABCG1, genes used here as markers linked to reverse cholesterol transport.

Researchers said larger trials will be needed, but, for now, the concept has its first human proof of principle.


Southern Yemen Leaders Seek Just Solutions at Upcoming Dialogue Conference in Riyadh

Yemeni officials are seen at the consultative meet in in Riyadh on Sunday. (Reuters)
Yemeni officials are seen at the consultative meet in in Riyadh on Sunday. (Reuters)
TT

Southern Yemen Leaders Seek Just Solutions at Upcoming Dialogue Conference in Riyadh

Yemeni officials are seen at the consultative meet in in Riyadh on Sunday. (Reuters)
Yemeni officials are seen at the consultative meet in in Riyadh on Sunday. (Reuters)

A consultative meeting on southern Yemen was held in Riyadh on Sunday, marking a return of the southern issue to the forefront of the regional scene. The meeting brought together leaderships, elders and senior figures from the South.

Saudi Arabia has been exerting firm efforts to steer the southern issue clear of political tensions and open conflicts and more towards dialogue that would lead to just solutions that would resolve pending disputes.

Sunday's meeting paves the way for a conference on southern Yemen hosted by Riyadh as part of its efforts to support a comprehensive political solution that tackles the southern issue and boosts security and stability in Yemen and the region.

The meeting was held amid unprecedented complications in Yemen and political, security and economic challenges facing the South. At the upcoming Riyadh conference, the gatherers will aim to reach a common vision on the South that is based on dialogue away from escalation and violence.

A closing statement following the consultative talks said the meeting reflects the South's collective will to reach a "just, secure and sustainable solution to the Southern issue."

A political path based on dialogue is the only way to avert more divisions and internal conflicts in the South, said the statement read by Presidential Leadership Council (PLC) member Abou Zaraa Al-Mahrami.

The participants "sensed during their direct meetings with Saudi leaderships and officials clear unconditional support for the legitimate demands of the southerners, starting with their right to reach a comprehensive political solution that ensures their dignity, security and stability," it added.

This path ensures the southerners' right to determine their political fate through a mechanism that does not marginalize any party, it went on to say.

The statement underscored "the southerners' options, including shaping the state and its political future, are their rights and their rights alone."

The upcoming Riyadh dialogue is a "rare historic opportunity" to set the southern issue back on the right path, said the statement, warning against attempts to undermine this opportunity by sparking side conflicts that serve regional parties that want chaos to persist.

Observers have said that the southern issue had been greatly undermined by controversial political and financial practices and by parties placing their own interests above national ones.

Saudi Arabia's sponsorship of the cause has one again returned it to the forefront in Yemen and made it an indispensable part of a comprehensive political solution in the country, they continued.

The statement called on the international community to support the renewed efforts related to the southern issue and to respect the aspirations of the southerners, saying this is critical to any comprehensive and sustainable settlement.

Commenting on the demonstrations that had taken place in the interim capital Aden, the statement said they reflect legitimate popular demands related to the southern issue and difficult living conditions.

The gatherers in Riyadh were also severely critical of Abu Dhabi's role in Yemen. Observers have said that the United Arab Emirates' role in supporting certain parties and not others helped deepen divisions in the South, prolong chaos and obstruct a comprehensive political solution.

The observers noted international reports that detected a similar approach adopted by the UAE in other countries, such as Sudan, Libya and Somalia, where its backing of local factions deepened crises instead of resolving them.

They contrasted this with Saudi Arabia's approach that supports the state, dialogue, stability and development.

The observers warned that the persistence of foreign meddling that deepens divisions in Yemen may force Riyadh to take a firmer stance to protect dialogue, to ensure that counter-terrorism efforts are not undermined and to achieve security and stability in Yemen.