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Scientists Develop New Drug to Prevent Preterm Birth

A pregnant woman walks past a street mural in Hong Kong on March 23, 2020. (Getty Images)
A pregnant woman walks past a street mural in Hong Kong on March 23, 2020. (Getty Images)
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Scientists Develop New Drug to Prevent Preterm Birth

A pregnant woman walks past a street mural in Hong Kong on March 23, 2020. (Getty Images)
A pregnant woman walks past a street mural in Hong Kong on March 23, 2020. (Getty Images)

The results of a study by researchers at the University of Texas Medical Branch (UTMB) may pave the way for a new medicine delivery system that could reduce the incidence of preterm labor and premature birth by allowing physicians to treat the “fetus as the patient”. The study has been published in the latest issue of the journal Science Advances.

It has long been suspected that preterm labor is triggered by inflammation caused by a sick fetus. A new study by scientists at UTMB has proved the hypothesis by studying several important assumptions about the relationship between the health of a mother and her unborn child.

During the study, the research team cooperated with ILIAS Biologics, a South Korean biotechnology company, to test their bioengineered exosomes as a delivery system for anti-inflammatory medicine directly to the fetus. Exosomes are natural nanoparticles or vesicles in our bodies, and we have trillions of them. By packaging the medicine inside a bioengineered exosome and injecting it into the mother intravenously, the exosomes travel through the blood system, cross the placental barrier and arrive in the fetus, where they deliver the medicine.

In laboratory tests with mice, there were several steps prior to testing the drug delivery. First, the team said it was important to prove that fetal cells, specifically immune cells, actually migrated through the mother's body to her uterine tissues as well as to her, which can cause inflammation, the leading cause of preterm labor.

Then, the team used bioengineered exosomes to deliver a special anti-inflammatory medicine, an inhibitor of NF-kB, called super repressor (SR) IkB, which is a protein compound that control DNA replication, production of cytokine, and cells' maintenance. The researchers proved that exosomes effectively delivered medicine to the fetus, slowed the migration of fetal immune cells, delayed preterm labor, and improved the fetus' survival rate.

"Mouse models provided valuable information to help understand the mechanisms often seen in humans. Future studies, including human clinical trials are needed to confirm laboratory results," said Dr. Ramkumar Menon, professor at the UTMB's Department of Obstetrics and Gynecology and Cell Biology, in a report published on the university's website.

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Caffeinated Beverages May Help Protect the Brain, Study Says

A cup of coffee and a cappuccino are seen at a Juan Valdez store in Bogota, Colombia June 5, 2019. (Reuters)
A cup of coffee and a cappuccino are seen at a Juan Valdez store in Bogota, Colombia June 5, 2019. (Reuters)
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Caffeinated Beverages May Help Protect the Brain, Study Says

A cup of coffee and a cappuccino are seen at a Juan Valdez store in Bogota, Colombia June 5, 2019. (Reuters)
A cup of coffee and a cappuccino are seen at a Juan Valdez store in Bogota, Colombia June 5, 2019. (Reuters)

Drinking a few cups of caffeinated coffee or tea every day may help in a small way to preserve brain power and prevent dementia, researchers reported on Monday.

People with the highest daily intake of caffeinated coffee had an 18% lower risk of developing dementia compared to those with the lowest such intake, according to a study based on responses to questionnaires by 132,000 U.S. adults spanning four decades.

The study, published in JAMA, also found that the people with the highest intake had a lower rate - by nearly 2 percentage points - of ‌self-perceived memory ‌or thinking problems compared to those with ‌the ⁠lowest intake.

Results were ‌similar with caffeinated tea, but not with decaffeinated beverages, the researchers said.

While the findings are encouraging, the study does not prove caffeine helps protect the brain, they said.

The magnitude of caffeine's effect, if any, was small, and there are other better-documented ways to protect cognitive function as people age, study leader Dr. Daniel Wang ⁠of Harvard Medical School said in a statement.

Lifestyle factors linked with lower risks of ‌dementia include physical exercise, a healthy diet ‍and adequate sleep, according to previous ‍research.

"Our study suggests that caffeinated coffee or tea consumption can ‍be one piece of that puzzle," Wang said.

The findings were most pronounced in participants who consumed two to three cups of caffeinated coffee or one to two cups of caffeinated tea daily, the researchers reported.

Those who drank caffeinated coffee also showed better performance on some objective tests of cognitive function, according to the ⁠study funded by the National Institutes of Health.

Further research is needed to validate the factors and mechanisms responsible for the findings, the researchers said.

They noted that bioactive ingredients in coffee and tea such as caffeine and polyphenols have emerged as possible factors that reduce nerve cell inflammation and damage while protecting against cognitive decline.

"We also compared people with different genetic predispositions to developing dementia and saw the same results - meaning coffee or caffeine is likely equally beneficial for people with high and low genetic risk of developing ‌dementia," study coauthor Dr. Yu Zhang of the Harvard T.H. Chan School of Public Health said in a statement.

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AlUla Announces Exceptional Ramadan Experiences

These programs come as part of efforts to enhance AlUla’s tourism experience - SPA
These programs come as part of efforts to enhance AlUla’s tourism experience - SPA
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AlUla Announces Exceptional Ramadan Experiences

These programs come as part of efforts to enhance AlUla’s tourism experience - SPA
These programs come as part of efforts to enhance AlUla’s tourism experience - SPA

AlUla Governorate is welcoming the holy month of Ramadan this year with a wide range of diverse tourism experiences that reflect the area’s distinctive character and rich cultural heritage, reinforcing its position as one of the Kingdom’s most prominent destinations to visit during the holy month.

During Ramadan, AlUla offers an integrated experience catering to different visitor preferences, including guided stargazing experiences, cultural events, and night markets, in addition to traditional dining experiences for Iftar and Suhoor, embodying the depth of AlUla’s cultural heritage and local identity.

The Ramadan programs in AlUla include a variety of standout events, such as Ramadan experiences at Maraya Hall, a cultural market, and live performances in the atmosphere of Ashar Valley, alongside heritage tours in AlUla Old Town that narrate stories of AlUla and its Ramadan customs, including the award-winning Incense Road Experience, SPA reported.

The programs also feature seasonal art exhibitions hosted across multiple cultural venues, including Design Space AlUla, the fourth edition of Desert X AlUla, and the Arduna exhibition at AlUla Oasis, in addition to experiences combining art, nature, and stargazing at Daimumah Oasis in collaboration with AlUla Manara.

Visitors are also offered tours to prominent archaeological sites, including Hegra, Dadan, and Jabal Ikmah, to explore ancient sites dating back centuries BCE and view unique rock inscriptions, as well as adventure experiences ranging from dinner and stargazing in Sharaan, hot-air balloon rides, mountain hiking trails, and safari tours.

These programs come as part of efforts to enhance AlUla’s tourism experience during the holy month of Ramadan and provide diverse options that meet visitor expectations, contributing to the growth of tourism activity and showcasing the governorate’s natural and cultural assets.

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NCW Releases over 10,000 Animals under Reintroduction Programs

The releases carried out by the center over the past years included more than 80 priority wildlife species - SPA
The releases carried out by the center over the past years included more than 80 priority wildlife species - SPA
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NCW Releases over 10,000 Animals under Reintroduction Programs

The releases carried out by the center over the past years included more than 80 priority wildlife species - SPA
The releases carried out by the center over the past years included more than 80 priority wildlife species - SPA

The National Center for Wildlife (NCW) announced that the total number of wildlife animals released under its breeding and reintroduction programs for locally threatened species has exceeded 10,000 animals, an achievement reflecting the scale of the center’s sustained efforts to develop wildlife, restore ecosystems, and enhance biodiversity across various regions of the Kingdom.

The releases carried out by the center over the past years included more than 80 priority wildlife species, including reem gazelles (sand gazelles), Arabian oryx, Idmi gazelles, mountain ibex, houbara bustards, ostriches, and sandgrouse, as part of efforts aimed at supporting the recovery of natural populations of these species and enhancing their sustainability within their environmental and historical ranges, SPA reported.

CEO of NCW Dr. Mohammad Qurban noted that release operations are among the key tools for restoring ecosystems and reducing ecological imbalance, as the return of wildlife to their natural habitats contributes to protecting biodiversity and improving environmental quality, which in turn supports habitat integrity, the continuity of plant and animal components, and the enhancement of ecosystem functions over the long term.

NCW continues to implement its strategic plans to develop wildlife, protect endangered species, and enhance the efficiency of natural habitat management through expanding breeding programs, enhancing applied scientific research, building national capacities, and applying the best international practices in biodiversity management, in addition to raising environmental awareness, engaging local communities, and supporting eco-tourism, thereby contributing to achieving the objectives of the Saudi Green Initiative and Saudi Vision 2030, and the National Environment Strategy, toward thriving and sustainable wildlife, biodiversity, and ecosystems.