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Scientists Create ‘Robotic Pill’ to Treat Osteoporosis

An illustration picture taken in Lille on May 7, 2017 shows pills, tablets, caplets and capsules of medicine. / AFP PHOTO / PHILIPPE HUGUEN
An illustration picture taken in Lille on May 7, 2017 shows pills, tablets, caplets and capsules of medicine. / AFP PHOTO / PHILIPPE HUGUEN
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Scientists Create ‘Robotic Pill’ to Treat Osteoporosis

An illustration picture taken in Lille on May 7, 2017 shows pills, tablets, caplets and capsules of medicine. / AFP PHOTO / PHILIPPE HUGUEN
An illustration picture taken in Lille on May 7, 2017 shows pills, tablets, caplets and capsules of medicine. / AFP PHOTO / PHILIPPE HUGUEN

A proven and effective medication for osteoporosis, which is currently only available as an injection, can be administered orally using a novel “robotic pill”, according to a study presented Saturday at ENDO 2023, the Endocrine Society's annual meeting in Chicago.

“We believe this study provides the first clinical evidence of safe and successful delivery of the osteoporosis drug teriparatide through an oral robotic pill,” said Arvinder Dhalla, who leads Clinical Development at Rani Therapeutics, the company that developed the technology. “Data from this study are very encouraging and should give hope to those suffering from chronic conditions that require painful injections, like osteoporosis,” she added.

When a person swallows the robotic pill, it moves through the stomach intact. In the intestine the pill releases a self-inflating balloon with a microsyringe, which injects a drug-filled microneedle and delivers the medication.

“The intestines do not have pain response to needles, so the injection is painless. The needle rapidly dissolves, and the medication is absorbed while the delivery mechanism deflates and is safely passed out of the body,” Dhalla explained.

“The robotic pill, which is essentially a swallowable auto-injector in the form of a pill, is designed to deliver the drug safely and efficiently as a painless intestinal injection,” she said.

The study of 39 healthy women evaluated the safety, tolerability and movement through the body of the robotic pill known as RT-102, containing a dose of the drug teriparatide (PTH 1-34).

Teriparatide is a synthetic form of the natural human parathyroid hormone. It has been in clinical use for decades as an injectable medication (under the brand name Forteo) for rebuilding brittle bones of osteoporosis patients. It is taken as a daily injection for up to two years.

Study participants were divided into three groups. Two groups received either a lower or higher dose delivered with the robotic pill, and the third group received a standard injection of teriparatide. Fluoroscopic imaging was used to track the robotic pill through and out the body. Drug concentrations were measured in blood samples collected over six hours.

The study found the bioavailability (the ability of the drug to be absorbed and used by the body) of the drug delivered by the robotic pill was comparable to or better than the drug given via the injection.

“This breakthrough technology of converting injections into oral pills is a significant step forward towards ending the burden of painful injections for millions of patients suffering from chronic diseases,” Dhalla concluded.

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Varieties

Snowstorm Paralyzes Vienna Airport

People wait at a tram stop after heavy snowfalls in Vienna, Austria, February 20, 2026. REUTERS/Elisabeth Mandl
People wait at a tram stop after heavy snowfalls in Vienna, Austria, February 20, 2026. REUTERS/Elisabeth Mandl
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Snowstorm Paralyzes Vienna Airport

People wait at a tram stop after heavy snowfalls in Vienna, Austria, February 20, 2026. REUTERS/Elisabeth Mandl
People wait at a tram stop after heavy snowfalls in Vienna, Austria, February 20, 2026. REUTERS/Elisabeth Mandl

Massive snowstorms caused power outages and transport chaos in Austria on Friday, forcing the Vienna airport to temporarily halt all flights.

Flights departing from the capital, a major European hub, were cancelled or delayed, and more than 230 arrivals were similarly disrupted or rerouted.

"Passengers whose flights have been delayed are asked not to come to the airport," the facility said in a statement.

The area received 20 centimeters (nearly eight inches) of snow, national news agency APA reported.

The main highway south of Vienna was closed for several hours, and other sections of highway were temporarily inaccessible because of snowdrift, stranded lorries or poor visibility, said the national automobile association, OAMTC.

According to AFP, electric companies reported power outages in several regions in the south and east, including Styria, where 30,000 homes lost electricity.

The weather was forecast to improve from around midday, but the risk of avalanches remained high.

Varieties

NASA Delivers Harsh Assessment of Botched Boeing Starliner Test Flight

NASA duo Butch Wilmore and Suni Williams were stuck on the ISS for nine months. Handout / NASA TV/AFP/File
NASA duo Butch Wilmore and Suni Williams were stuck on the ISS for nine months. Handout / NASA TV/AFP/File
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NASA Delivers Harsh Assessment of Botched Boeing Starliner Test Flight

NASA duo Butch Wilmore and Suni Williams were stuck on the ISS for nine months. Handout / NASA TV/AFP/File
NASA duo Butch Wilmore and Suni Williams were stuck on the ISS for nine months. Handout / NASA TV/AFP/File

NASA on Thursday blamed what it called engineering vulnerabilities in Boeing's Starliner spacecraft along with internal agency mistakes in a sharply critical report assessing a botched mission that left two astronauts stranded in space.

The US space agency labeled the 2024 test flight of the Starliner capsule a "Type A" mishap -- the same classification as the deadly Challenger and Columbia shuttle disasters -- a category that reflects the "potential for a significant mishap," it said.

The failures left a pair of NASA astronauts stranded aboard the International Space Station for nine months in a mission that captured global attention and became a political flashpoint.

"Starliner has design and engineering deficiencies that must be corrected, but the most troubling failure revealed by this investigation is not hardware. It's decision-making and leadership," said NASA administrator Jared Isaacman in a briefing.

"If left unchecked," he said, this mismanagement "could create a culture incompatible with human spaceflight."

The top space official said the investigation found that a concern for the reputation of Boeing's Starliner clouded an earlier internal probe into the incident.

"Programmatic advocacy exceeded reasonable bounds and place the mission, the crew and America's space program at risk in ways that were not fully understood at the time," Isaacman said.

He said Starliner currently "is less reliable for crew survival than other crewed vehicles" and that "NASA will not fly another crew on Starliner until technical causes are understood and corrected" and a problematic propulsion system is fixed.

But the administrator insisted that "NASA will continue to work with Boeing, as we do all of our partners that are undertaking test flights."

In a statement, Boeing said it has "made substantial progress on corrective actions for technical challenges we encountered and driven significant cultural changes across the team that directly align with the findings in the report."

- 'We failed them' -

Isaacman also had harsh words for internal conduct at NASA.

"We managed the contract. We accepted the vehicle, we launched the crew to space. We made decisions from docking through post-mission actions," he told journalists.

"A considerable portion of the responsibility and accountability rests here."

In June 2024 Butch Wilmore and Suni Williams embarked on what was meant to be an eight-to-14-day mission. But this turned into nine months after propulsion problems emerged in orbit and the Starliner spacecraft was deemed unfit to fly them back.

The ex-Navy pilots were reassigned to the NASA-SpaceX Crew-9 mission. A Dragon spacecraft flew to the ISS that September with a team of two, rather than the usual four, to make room for the stranded pair.

The duo, both now retired, were finally able to arrive home safely in March 2025.

"They have so much grace, and they're so competent, the two of them, and we failed them," NASA associate administrator Amit Kshatriya told Thursday's briefing.

"The agency failed them."

Kshatriya said the details of the report were "hard to hear" but that "transparency" was the only path forward.

"This is not about pointing fingers," he said. "It's about making sure that we are holding each other accountable."

Both Boeing and SpaceX were commissioned to handle missions to the ISS more than a decade ago.

Varieties

Abandoned Baby Monkey Finds Comfort in Stuffed Orangutan

A baby Japanese macaque named Punch sits next to a stuffed orangutan at Ichikawa City Zoo, in Ichikawa, Chiba Prefecture, Japan, February 19, 2026. REUTERS/Kim Kyung-Hoon
A baby Japanese macaque named Punch sits next to a stuffed orangutan at Ichikawa City Zoo, in Ichikawa, Chiba Prefecture, Japan, February 19, 2026. REUTERS/Kim Kyung-Hoon
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Abandoned Baby Monkey Finds Comfort in Stuffed Orangutan

A baby Japanese macaque named Punch sits next to a stuffed orangutan at Ichikawa City Zoo, in Ichikawa, Chiba Prefecture, Japan, February 19, 2026. REUTERS/Kim Kyung-Hoon
A baby Japanese macaque named Punch sits next to a stuffed orangutan at Ichikawa City Zoo, in Ichikawa, Chiba Prefecture, Japan, February 19, 2026. REUTERS/Kim Kyung-Hoon

At a zoo outside Tokyo, the monkey enclosure has become a must-see attraction thanks to an inseparable pair: Punch, a baby Japanese macaque, and his stuffed orangutan companion.

Punch's mother abandoned the macaque when he was born seven months ago at the Ichikawa City Zoo and when an onlooker noticed and alerted zookeepers, they swung into action.

Japanese baby macaques typically cling to their mothers to build muscle strength and for a ‌sense of security, ‌so Punch needed a swift intervention, zookeeper ‌Kosuke ⁠Shikano said. The keepers ⁠experimented with substitutes including rolled-up towels and other stuffed animals before settling on the orange, bug-eyed orangutan, sold by Swedish furniture brand IKEA.

“This stuffed animal has relatively long hair and several easy places to hold," Shikano said. "We thought that its resemblance to a monkey might help ⁠Punch integrate back into the troop later ‌on, and that’s why ‌we chose it."

Punch has rarely been seen without it since, ‌dragging the cuddly toy everywhere even though it is ‌bigger than him, and delighting fans who have flocked to the zoo since videos of the two went viral, Reuters reported.

“Seeing Punch on social media, abandoned by his parents but still trying ‌so hard, really moved me," said 26-year-old nurse Miyu Igarashi. "So when I got the ⁠chance to ⁠meet up with a friend today, I suggested we go see Punch together.”

Shikano thinks Punch's mother abandoned him because of the extreme heat in July when she gave birth.

Punch has had some differences with the other monkeys as he has tried to communicate with them, but zookeepers say that is part of the learning process and he is steadily integrating with the troop.

"I think there will come a day when he no longer needs his stuffed toy," Shikano said.