Drug Protects Kidneys, Heart in Diabetic Patients

This Jan. 3, 2009, file photo shows a person with diabetes testing his blood sugar level in Kamen, Germany. (AP)
This Jan. 3, 2009, file photo shows a person with diabetes testing his blood sugar level in Kamen, Germany. (AP)
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Drug Protects Kidneys, Heart in Diabetic Patients

This Jan. 3, 2009, file photo shows a person with diabetes testing his blood sugar level in Kamen, Germany. (AP)
This Jan. 3, 2009, file photo shows a person with diabetes testing his blood sugar level in Kamen, Germany. (AP)

A recent Canadian study has found that a drug prescribed to treat heart failure could protect kidney and heart health in individuals with type 2 diabetes and chronic kidney disease.

Results from the study were presented on November 4, at ASN Kidney Week 2023 organized by the American Society of Nephrology, in Philadelphia.

The study of a drug named “Sotagliflozin”, which has been approved by the FDA in May as a heart failure treatment, also involved non-diabetic patients.

Sotagliflozin is a Sodium-glucose cotransporter-2 (SGLT2) inhibitor, which lowers blood sugar by inhibiting glucose absorption in the kidneys, and can also be used to treat type 2 diabetes.

Researchers have found that these drugs provide kidney- and heart-related benefits to patients with and without diabetes.

During the study, the research team observed 10,584 patients with type 2 diabetes, chronic kidney disease and cardiovascular factors to receive sotagliflozin or placebo.

Over a median follow-up of 16 months, the researchers found sotagliflozin reduced the risk of glomerular filtration by 50 percent, and dialysis or kidney transplant by 38 percent.

They also found that compared to placebo, sotagliflozin reduced the risk of heart and kidney problems, as well as cardiovascular diseases-related deaths by 23 percent.

“These effects add to the already reported benefits of sotagliflozin in reducing both heart failure and ischemic events such as myocardial infarction or stroke,” said corresponding author David Cherney of the University of Toronto.

“Sotagliflozin is now FDA approved to reduce the risk of cardiovascular death and heart failure events with a broad label that includes patients with heart failure or chronic kidney disease, so the drug is now an option for nephrologists and cardiologists, as well as primary care physicians, to prescribe,” he told the York Alert website.



Mobile Cinema Brings Tunisians Big Screen Experience

Movie theaters are scarce in Tunisia, numbering at just 15 and largely concentrated in major urban hubs - AFP
Movie theaters are scarce in Tunisia, numbering at just 15 and largely concentrated in major urban hubs - AFP
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Mobile Cinema Brings Tunisians Big Screen Experience

Movie theaters are scarce in Tunisia, numbering at just 15 and largely concentrated in major urban hubs - AFP
Movie theaters are scarce in Tunisia, numbering at just 15 and largely concentrated in major urban hubs - AFP

Like many of his fellow Tunisians, 23-year-old Amine Elhani has never been to the cinema, but now, thanks to a mobile theater touring the country, he can finally enjoy the big screen.

The bright red truck of CinemaTdour, or "moving cinema", has transformed parking lots and factory grounds in underserved towns and neighbourhoods across the North African country into pop-up theaters.

In the central town of Djemmal, dozens of workers unloaded the expandable truck, easily setting up a fully equipped outdoor movie theater with 100 seats.

"The screen is huge, and the sound effects are amazing," said Elhani, who had so far only watched films on his phone or computer.

He had "never had the chance to go to a movie theater", he told AFP.

"It's a fantastic experience, especially because I'm watching with friends."

Movie theaters are scarce in Tunisia, numbering at just 15 and largely concentrated in major urban hubs.

Recognizing this gap, CinemaTdour was launched in May by private cultural network Agora and nonprofit Focus Gabes, with funding from private donors.

"We wanted a way to reach as many viewers as possible, in a short time and on a limited budget, while offering them an authentic cinematic experience," project director Ghofrane Heraghi told AFP.

Mobile cinemas have long existed in other countries, but Heraghi said CinemaTdour was "unique" for turning a truck into a full-fledged theater.

Without government funding, CinemaTdour relies heavily on partnerships with private companies to cover costs like film rights, maintenance and staffing.

The truck itself was purchased on credit for about one million Tunisian dinars ($315,000), Heraghi said, with annual operating expenses of around 500,000 dinars.

For 10 days in Djemmal, residents could watch films for free thanks to a partnership with German car parts manufacturer Draxlmaier, which has a factory in the town.

Jihene Ben Amor, Draxlmaier's communications manager in Tunisia, said the company wanted to "contribute to the development" of remote and underserved regions where it operates.

For many workers, earning up to 1,000 dinars a month, the cost of tickets and the journey to a main city with a movie theater can be prohibitive.

"Having this cinema right outside their workplace also gives workers a sense of pride and belonging," said Ben Amor.

- 'Social impact' -

After Djemmal, CinemaTdour set up in Hay Hlel, an impoverished neighbourhood of the capital Tunis.

Many children gathered around the pop-up theater, eager for their turn.

Yomna Warhani, 11, was beaming with excitement, anticipating her first ever movie screening.

"I can't wait to see what it's like inside and what films they'll show," she said.

Nejiba El Hadji, a 47-year-old mother of four, said: "It's not just the kids who are thrilled, believe me."

To her, the mobile cinema was a rare source of joy in an otherwise bleak environment.

"We have nothing here, no cultural centers and no entertainment, just the streets," said Hadji.

"People say our kids are lost, but no one does anything about it."

CinemaTdour's two-week stay in Hay Hlel was funded by the World Health Organization, with screenings themed on mental health, smoking and drug abuse, and violence against women.

The shows were tailored for younger audiences as well as for viewers with hearing or visual impairments.

Heraghi, the project head, said that "what drives us is the social impact of culture."

"We want to break stereotypes, shift mindsets, and promote values like social cohesion and community spirit."

In just a few months, CinemaTdour has reached more than 15,000 people, including 7,500 in the southern oasis town of Nefta where a month of free screenings was sponsored by a date exporter.

The project now hopes to secure funding for additional trucks to expand its activities across the country.

But Heraghli has even bigger aspirations, she said, "taking it to Algeria, Libya, and maybe even across Africa".