Scientists: Analysis of Beethoven’s Hair Reveals Possible Cause of Mysterious Ailments

(FILES) A figurine of German composer Ludwig van Beethoven is seen in the souvenir shop of the Beethovenhaus museum, in Baden bei Wien, Austria. (Photo by Joe Klamar / AFP)
(FILES) A figurine of German composer Ludwig van Beethoven is seen in the souvenir shop of the Beethovenhaus museum, in Baden bei Wien, Austria. (Photo by Joe Klamar / AFP)
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Scientists: Analysis of Beethoven’s Hair Reveals Possible Cause of Mysterious Ailments

(FILES) A figurine of German composer Ludwig van Beethoven is seen in the souvenir shop of the Beethovenhaus museum, in Baden bei Wien, Austria. (Photo by Joe Klamar / AFP)
(FILES) A figurine of German composer Ludwig van Beethoven is seen in the souvenir shop of the Beethovenhaus museum, in Baden bei Wien, Austria. (Photo by Joe Klamar / AFP)

High levels of lead detected in authenticated locks of Ludwig van Beethoven’s hair suggest that the composer had lead poisoning, according to new research.

In addition to hearing loss, the famed classical composer had recurring gastrointestinal complaints throughout his life, experienced two attacks of jaundice and faced severe liver disease, CNN reported.

It is believed that Beethoven died from liver and kidney disease at age 56.

The composer expressed his wish that his ailments be studied and shared so “as far as possible at least the world will be reconciled to me after my death.”

An international team of researchers set out nearly a decade ago to partially fulfill Beethoven’s wish by studying locks of his hair, CNN said. Using DNA analysis, the team determined which ones truly belonged to the composer and which were fraudulent, and sequenced Beethoven’s genome by analyzing his authenticated locks.

The findings, published in a March 2023 report, revealed that Beethoven had significant genetic risk factors for liver disease and a hepatitis B infection before his death. But the results didn’t provide any insights into the underlying causes of his deafness, which began in his 20s, or his gastrointestinal issues.

Beethoven’s genome was made publicly available, inviting researchers around the world to investigate lingering questions about Beethoven’s health.

Meanwhile, scientists continue to figuratively go over the authenticated locks of Beethoven’s hair with a fine-tooth comb, teasing out surprising insights.

In addition to high concentrations of lead, the latest findings showed arsenic and mercury that remain trapped in the composer’s strands nearly 200 years after his death, according to a new letter published Monday in the journal Clinical Chemistry. And the insights could provide new windows not only into understanding Beethoven’s chronic health ailments, but the complicated nuances of his life as a composer, CNN said.



Ozempic Hailed as 'Fountain of Youth' that Slows Aging

The is available under the brand names Wegovy and Ozempic (Photo by Reuters)
The is available under the brand names Wegovy and Ozempic (Photo by Reuters)
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Ozempic Hailed as 'Fountain of Youth' that Slows Aging

The is available under the brand names Wegovy and Ozempic (Photo by Reuters)
The is available under the brand names Wegovy and Ozempic (Photo by Reuters)

The anti-obesity drug Ozempic could slow down ageing and has “far-reaching benefits” beyond what was imagined, researchers have suggested.

Multiple studies have found semaglutide (available under the brand names Wegovy and Ozempic) reduced the risk of death in people who were obese or overweight and had cardiovascular disease without diabetes, The Independent reported.

Responding to research published in JACC, the flagship journal of the American College of Cardiology, Professor Harlan M Krumholz from the Yale School of Medicine, said: “Semaglutide, perhaps by improving cardiometabolic health, has far-reaching benefits beyond what we initially imagined.”

He added: “These ground-breaking medications are poised to revolutionise cardiovascular care and could dramatically enhance cardiovascular health.”

Multiple reports also quoted Professor Krumholz saying: “Is it a fountain of youth?”

He said: “I would say if you’re improving someone’s cardiometabolic health substantially, then you are putting them in a position to live longer and better.

“It’s not just avoiding heart attacks. These are health promoters. It wouldn’t surprise me that improving people’s health this way actually slows down the ageing process.”

The studies, presented at the European Society of Cardiology Conference 2024 in London, were produced from the Select trial which studied 17,604 people aged 45 or older who were overweight or obese and had established cardiovascular disease but not diabetes.

They received 2.4 mg of semaglutide or a placebo and were tracked for more than three years.

A total of 833 participants died during the study with 5 percent of the deaths were related to cardiovascular causes and 42 per cent from others.

Infection was the most common cause death beyond cardiovascular, but it occurred at a lower rate in the semaglutide group than the placebo group.

People using the weight-loss drug were just as likely to catch Covid-19, but they were less likely to die from it – 2.6 percent dying among those on semaglutide versus 3.1 per cent on the placebo.

Researchers found women experienced fewer major adverse cardiovascular events, but semaglutide “consistently reduced the risk” of adverse cardiovascular outcomes regardless of sex.

Dr Benjamin Scirica, lead author of one of the studies and a professor of cardiovascular medicine at Harvard Medical School, said: “The robust reduction in non-cardiovascular death, and particularly infections deaths, was surprising and perhaps only detectable because of the Covid-19-related surge in non-cardiovascular deaths.

“These findings reinforce that overweight and obesity increases the risk of death due to many etiologies, which can be modified with potent incretin-based therapies like semaglutide.”

Dr Jeremy Samuel Faust, an emergency medicine physician at Brigham and Women’s Hospital, praised the researchers for adapting the study to look at Covid-19 when the pandemic started.

He said the findings that the weight-loss drug to reduce Covid-19 mortality rates were “akin to a vaccine against the indirect effects of a pathogen.”