Bayern Munich coach Vincent Kompany confirmed captain Manuel Neuer and Joshua Kimmich were among several absentees for Sunday's Bundesliga match against Heidenheim.
Speaking to reporters on Saturday ahead of the final match of the calendar year, Kompany said Sacha Boey would also miss out through injury, Konrad Laimer is suspended while Nicolas Jackson is away on Africa Cup of Nations duty with Senegal.
Long-term absentee Jamal Musiala returned to team training this week but would not return until 2026.
France winger Michael Olise, who had eye surgery earlier in the week, is expected to return, as is Luis Diaz who missed out last week with suspension.
The dependable Olise is yet to miss a match with injury since joining Bayern from Crystal Palace in 2024.
According to AFP, Kompany said Germany captain Kimmich is still struggling with an ankle complaint picked up on international duty in November.
"We've had so many matches recently, at a certain point the pain becomes too much," Kompany said, adding Kimmich had "been playing at the limit of what's too painful" for weeks.
Unbeaten Bayern have enjoyed a close to flawless league campaign this season, dropping just four points in their opening 14 matches.
League leaders Bayern sit six points clear of second-placed Borussia Dortmund, who have played a game more.
On Saturday, German tabloid Bild reported Bayern was set to extend with winger Serge Gnabry by two years until 2028.
The former Arsenal forward has played at Bayern since 2017 and has impressed this campaign, with five goals and seven assists in all competitions.
The 30-year-old has also returned to form at international level, with three goals and an assist in Germany's six World Cup qualifiers.
