Barcelona cruised to a 3-0 victory over Levante to reclaim pole position in La Liga on Sunday.
After Real Madrid fell to a 2-1 defeat at Osasuna on Saturday Hansi Flick's side moved a point clear of their bitter rivals with a comfortable victory at Camp Nou against the team in 19th.
Marc Bernal and Frenkie de Jong gave Barca a commanding first-half lead and Fermin Lopez wrapped up the win with a sensational drive late on.
Barcelona were glad to get back to winning ways after a 4-0 thrashing by Atletico Madrid in the Copa del Rey semi-final first leg last week and then a 2-1 defeat by Girona on Monday in La Liga.
Despite Flick's calls for improvement in defence, Barca were as open as ever, although Levante's poor finishing meant they could not capitalize, AFP reported.
Bernal sent Barca ahead after good work by Joao Cancelo, who impressed on a rare start after his arrival on loan in January, and Eric Garcia.
Veteran Polish forward Robert Lewandowski could have doubled Barca's advantage but fired into the ground and over the bar when well placed.
Cancelo hit the post with a cross aimed at Lewandowski, before the Portuguese defender carved out the second for De Jong with a similar ball in from the left.
De Jong delivered the finishing touch to give Barca a two-goal lead at the break.
Garcia should have expanded Barcelona's lead early in the second half but nodded wide from Jules Kounde's tempting cross.
Eventually substitute Lopez got a spectacular third, rattling home a long-range effort in off the post.
The midfielder might have added a fourth late on but Levante goalkeeper Mathew Ryan denied him with a fine reflex save.
Flick was able to bring back midfielder Pedri as a substitute after a month out with a hamstring injury, with the Spaniard likely to be key in the testing weeks ahead.
Earlier Sevilla earned a 1-0 win at Getafe, while third-place Villarreal host Valencia later on.
