Novak Djokovic's stay at the Cincinnati Open was a short one. It also might be his last.
The 24-time major champion fell to Thiago Agustin Tirante 2-6, 6-4, 6-4 on Saturday in a match that took 2 hours, 44 minutes in hot and humid conditions.
A 25-year-old from Argentina, Tirante is ranked No. 50 in the world. Djokovic — a three-time Cincinnati champion and No. 5 in the rankings — was playing for the first time since his loss to top-ranked Jannik Sinner in the semifinals at Wimbledon.
Up next for Djokovic is the US Open, which starts Aug. 30 in New York.
Djokovic appeared to struggle physically in the heat and had his 10-match winning streak in Cincinnati snapped. The 39-year-old told reporters that an unspecified health condition made it difficult for him to play in hot and humid weather.
“It’s just a condition that I have, health-wise, that has been bothering me for the past couple of years,” Djokovic said. “A lot of issues, especially when it is humid and it is hot. I did anticipate it (would be humid), but there are all these things, like nerves and everything involved that make it worse, and that’s what happened.”
Djokovic has had plenty of success in Cincinnati, with a 45-13 record and titles in 2018, 2020 and 2023. But he wasn't sure he would return.
“I certainly hope so, but it looks more likely not, unfortunately,” Djokovic said. “But let’s see what the future brings.”
Djokovic saved 13 of the 15 break points he faced. Tirante broke Djokovic's serve in the ninth game of the final set and then served it out.
“I think this is the best win of my career,” Tirante said. “I think I really did a good job inside the court. I managed very well the nerves of playing against a legend like Novak.”
In a rain-delayed match that ended at 2:15 a.m. Sunday, top-seeded Alexander Zverev rallied to avoid a third straight loss, beating Cameron Norrie 3-6, 6-3, 6-3.
After losing to Jannik Sinner in the Wimbledon final, Zverev, the French Open champion, returned to play in Montreal and fell to Tallon Griekspoor in his opener Aug. 5.
On the women's side, Alexandra Eala of the Philippines continued her run of strong play with a victory over Elena-Gabriela Ruse, who lost the first set and stopped playing in the second with an ankle injury.
Eala, who is No. 20 in the rankings, won her first WTA singles title in Washington earlier this month and has won eight of her last nine matches.
American Jessica Pegula beat Simona Waltert 6-3, 6-2, improving her record to 25-6 on hard courts in 2026. The third-ranked Pegula won the title in Cincinnati in 2024.
