Russia said on Friday that it shot down nearly 1,200 Ukrainian drones overnight, one of the largest swarms sent by Kyiv that killed four people.
Ukrainian authorities reported that another night of Russian attacks had set a hospital ablaze and killed at least three people.
The deadly attacks came a day after intense shuttle diplomacy in US-led talks to end the war approaching its fifth year.
US envoys Steve Witkoff and Jared Kushner held hours of talks with Russian President Vladimir Putin in Moscow on Thursday before jetting to Dublin to huddle with Ukrainian President Volodymyr Zelensky.
"In the course of the previous night... aerial defense systems intercepted and destroyed 1,198" Ukrainian drones over more than 15 Russian regions, Russia's defense ministry said in a statement.
Four people working in an industrial zone, home to an oil refinery and a chemical factory, died in the southern Volgograd region, local authorities said.
In Ukraine, a hospital in Kyiv was damaged after a Russian attack triggered a fire and forced people to seek shelter. One person was wounded.
In Odesa, two people were killed and five wounded in the overnight barrage, with "private residential houses and cars" damaged, regional governor Oleg Kiper said on Telegram.
A Russian attack on Zaporizhzhia in the southeast killed a 17-year-old boy, acting regional governor Mykhailo Semikin said.
Four people, who rescuers managed to pull from under the rubble, were wounded.
Another Russian strike hit the city of Rivne, in a northwestern region far from the frontline, damaging a kindergarten and wounding six people, including two children.
Ukraine has intensified its retaliatory drone attacks on Russia's energy industry over the past year-and-a-half, seeking to cut the Kremlin's revenues and undermine its ability to finance the war Moscow launched in February 2022.
Russia is heavily targeting Ukraine's own energy grid with aerial barrages, leaving residents across the country without power as temperatures plunge ahead of winter.