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HIV Might be Dormant in Brain, New Study Suggests

A colorized electron microscope image shows a single humanimmunodeficiency virus (HIV) as it buds from a human immune cell,which the virus had infected. (NIAID via AP)
A colorized electron microscope image shows a single humanimmunodeficiency virus (HIV) as it buds from a human immune cell,which the virus had infected. (NIAID via AP)
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HIV Might be Dormant in Brain, New Study Suggests

A colorized electron microscope image shows a single humanimmunodeficiency virus (HIV) as it buds from a human immune cell,which the virus had infected. (NIAID via AP)
A colorized electron microscope image shows a single humanimmunodeficiency virus (HIV) as it buds from a human immune cell,which the virus had infected. (NIAID via AP)

A new study published June 16 in the Journal of Clinical Investigations, found that microglial cells, specialized immune cells with a long lifespan in the brain, can serve as a stable viral reservoir for latent HIV.

 

As a part of its life cycle, the human immunodeficiency virus-1 (HIV) inserts a copy of its DNA into human immune cells. Some of these newly infected immune cells can then transition into a dormant, latent state for a long period of time.

 

Although current therapies, such current antiretroviral therapy (ART), can successfully block the virus from replicating further, it cannot eradicate latent HIV. If treatment is ever discontinued, the virus can rebound from latency and reignite the progression of HIV infection to AIDS.

 

In the new study, led by scientists from the University of North Carolina’s School of Medicine, it has been confirmed that microglial cells can serve as a stable viral reservoir for latent HIV. The team studied the brains of macaques with the simian immunodeficiency virus (SIV), a virus that is closely related to HIV, to get a better understanding of how to extract and purify viable cells from primate brain tissue.

 

Researchers used physical separation techniques and antibodies to selectively remove microglial cells. Using these techniques, researchers then obtained samples that were donated by HIV+ people who were enrolled in “The Last Gift” Study at the University of California San Diego (UCSD).

 

The study involved altruistic HIV+ people, who are taking ART but suffering from other terminal illnesses, will their bodies to further the HIV research project. Now that the researchers know that latent HIV can take refuge in microglial cells in the brain, they are considering plans to target this type of reservoir.

 

“Since latent HIV in the brain is radically different from the virus in the periphery, researchers believe that it has adapted special characteristics to replicate in the brain,” explained first author Yuyang Tang, assistant professor of medicine in the Division of Infectious Diseases at UNC.

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KAUST Unveils Landmark Coral Facility on Red Sea, Advancing Saudi Scientific Expertise and Marine Conservation

KCRI is designed to restore the Red Sea reefscape and offer a framework that coral restoration programs worldwide can adopt. (SPA)
KCRI is designed to restore the Red Sea reefscape and offer a framework that coral restoration programs worldwide can adopt. (SPA)
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KAUST Unveils Landmark Coral Facility on Red Sea, Advancing Saudi Scientific Expertise and Marine Conservation

KCRI is designed to restore the Red Sea reefscape and offer a framework that coral restoration programs worldwide can adopt. (SPA)
KCRI is designed to restore the Red Sea reefscape and offer a framework that coral restoration programs worldwide can adopt. (SPA)

The King Abdullah University of Science and Technology (KAUST) launched the KAUST Coral Restoration Initiative’s large-scale coral facility, restoring and advancing one of Saudi Arabia’s most precious natural assets, reported the Saudi Press Agency on Wednesday.

On Saudi Arabia’s Red Sea coast, the KAUST Coral Restoration Initiative (KCRI) land-based nursery and research campus is now growing corals at scale. It is designed to produce up to 360,000 corals a year, to outplant more than two million corals across 100 hectares of reef at Shushah Island by 2030, and to establish a resilient reef ecosystem by 2040.

This opening of the world’s largest coral restoration facility, announced at COP31 in Antalya, arrives at a moment of acute urgency for the world’s reefs. The fourth global coral bleaching event, confirmed by NOAA as the most severe in recorded history, affected more than 84% of the world’s reef area between 2023 and 2025.

Coral reefs support around a quarter of all marine species, protect coastlines from storms and sustain the livelihoods of more than 500 million people. (SPA)

The Red Sea is the right place to start. Its corals live in some of the warmest, saltiest waters on Earth, and they hold lessons about resilience that reefs everywhere will need. KCRI combines the Red Sea’s unique corals with KAUST’s world-class marine science to learn how corals can be grown at scale and conditioned to withstand warmer water before they return to the reef.

The initiative also draws on the expertise of the Coral Research and Development Accelerator Platform (CORDAP), which works internationally to accelerate scientific and technological solutions for coral reef conservation and restoration.

KCRI brings four components together in a single restoration system, including a large-scale land-based coral nursery, sea-based nurseries, more than 50 research programs spanning coral probiotics, heat-resilient corals, robotics and AI-driven modelling and eCoral, an AI-driven digital twin of the reefscape that guides where and how every coral is planted and monitored.

Saudi scientists, divers and aquarists are playing an important role in KCRI’s restoration efforts, developing specialist expertise in coral cultivation, marine science and reef restoration. (SPA)

Saudi scientists, divers and aquarists are playing an important role in KCRI’s restoration efforts, developing specialist expertise in coral cultivation, marine science and reef restoration. Beyond its restoration activities, KCRI represents a long-term investment in Saudi Arabia’s marine science capabilities.

Coral reefs support around a quarter of all marine species, protect coastlines from storms and sustain the livelihoods of more than 500 million people. KCRI is designed to restore the Red Sea reefscape and offer a framework that coral restoration programs worldwide can adopt.

KAUST is also working with international partners on how coral diversity can be safeguarded for future generations.

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Portugal Closes All Schools and Non-Essential Services Ahead of a Major Atlantic Storm

Heavy machinery clears the debris from a landslide along the Marocos road in Machico municipality, on the Portuguese island of Madeira, due to severe weather caused by the passage of Storm Charles, 11 November 2026. (EPA)
Heavy machinery clears the debris from a landslide along the Marocos road in Machico municipality, on the Portuguese island of Madeira, due to severe weather caused by the passage of Storm Charles, 11 November 2026. (EPA)
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Portugal Closes All Schools and Non-Essential Services Ahead of a Major Atlantic Storm

Heavy machinery clears the debris from a landslide along the Marocos road in Machico municipality, on the Portuguese island of Madeira, due to severe weather caused by the passage of Storm Charles, 11 November 2026. (EPA)
Heavy machinery clears the debris from a landslide along the Marocos road in Machico municipality, on the Portuguese island of Madeira, due to severe weather caused by the passage of Storm Charles, 11 November 2026. (EPA)

Portugal closed all schools and shuttered non-essential public services on Wednesday as a major Atlantic storm headed for the country's mainland.

Streets remained largely deserted ahead of the arrival of Storm Charles after the government told people to stay at home as heavy rain and rough seas were expected to batter the Portuguese coast, with wind gusts of up to 140 kph (85 mph).

It was the first time in living memory that Portugal’s roughly 8,000 schools had canceled classes nationwide over a storm forecast.

Buses without passengers drove through the country's capital, Lisbon, where some streets flooded due to clogged drains. A national supermarket chain closed its stores, while an international technology conference in Lisbon attended by around 70,000 people called off the day's events.

In January, the country's center-right government faced harsh criticism for its weak response when Storm Kristin hit central Portugal, felling thousands of trees and causing widespread property damage that is still being repaired.

The brunt of Storm Charles was expected to hit the Atlantic coast on Wednesday afternoon and evening, coming from the southwest after it had struck the Portuguese island of Madeira on Tuesday with 130 kph (81 mph) winds.

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Once the World's Fastest, Ocean Liner Will Become Largest Artificial Reef

The S.S. United States crossed the Atlantic more than 800 times. (Getty Images)
The S.S. United States crossed the Atlantic more than 800 times. (Getty Images)
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Once the World's Fastest, Ocean Liner Will Become Largest Artificial Reef

The S.S. United States crossed the Atlantic more than 800 times. (Getty Images)
The S.S. United States crossed the Atlantic more than 800 times. (Getty Images)

An ocean liner that is longer than the Titanic and was once the fastest on the seas is headed to a final home on the floor of the Gulf of Mexico as the world's largest artificial reef.

The S.S. United States is scheduled to be sunk Wednesday off the coast of the Florida Panhandle, fulfilling a long-planned $13.5 million project aimed at attracting more divers and fishing enthusiasts to the area while creating a home for tuna, marlin and swordfish.

The project will keep what had been a technological marvel when it made its maiden voyage in 1952 from becoming scrap metal.

The S.S. United States crossed the Atlantic more than 800 times, carrying old Hollywood stars like Grace Kelly and Elizabeth Taylor. Other passengers have included President John F. Kennedy and Britain’s former King Edward VIII. In 1968, a young Bill Clinton took it when he went to Oxford University, decades before he was elected president.

In preparation for the sinking, organizers removed the 65-foot smokestacks and plan to have them anchor a new museum that celebrates the ship. Once aboard, passengers were treated to dinners that included caviar, roast duckling, smoked ox tongue and Calf's Head en Tortue.

“It was our goal to make sure that she wasn’t lost forever,” said David Lawrence, a member of the board for the S.S. United States Conservancy, which is dedicated to preserving the ship.

The ship will be sunk without using explosives

Federal environmental and explosives rules prevent Okaloosa County, Florida, and its contractor from using explosives to scuttle the ship, said Nick Tomecek, the county's spokesperson. Concerns about inclement weather prompted officials to move up the sinking by a day.

The S.S. United States has pipes that pulled seawater into tanks as part of the system that cooled its boilers, he said, and those tanks have been removed so that once the valves are opened, water will flood the hull. Workers also have cut 10-foot by 10-foot holes in the decks, and more than 400 portholes have been removed.

The ship is to sink in about 180 feet (55 meters) of water, with its top deck about 60 feet (18 meters) below the surface — shallow enough that inexperienced divers can visit. It will settle on the floor of the waters about 25 miles (40 kilometers) southwest of Destin, between Panama City and Pensacola.

Larger than the Titanic, the ship's first voyage set a speed record

More than 3,000 workers helped build the S.S. United States in 1950 and 1951 in Virginia. An Associated Press reporter and President Harry Truman's daughter, Margaret, were among 1,700 passengers for the first voyage.

The ship's average speed for that trip was almost 41 miles (66 kilometers) per hour, besting a record set by Britain's R.M.S. Queen Mary in 1938 by 4.5 miles (7.2 kilometers) per hour, according to the AP's dispatch.

The S.S. United States set the record even though its journey ended in the face of a full gale that reached 69 miles (111 kilometers) per hour — “so strong it blew a ping pong table off the deck,” AP reported.

At 990 feet (302 meters), the ship is 108 feet (33 meters) longer than the ill-fated Titanic, which hit an iceberg and sank on its first voyage across the Atlantic.

“She really embodies and expresses this country’s best,” said Susan Gibbs, the granddaughter of the ship's designer. “She represents pride and resilience and strength and beauty.”

The ship's resting place has many artificial reefs

About 500 artificial reefs are located in the waters near where the S.S. United States will rest, Tomecek said.

Previously, the largest artificial reef came from the 2006 scuttling of an aircraft carrier, the USS Oriskany in the Gulf off of Pensacola — near enough to the S.S. United States site that an experienced diver could visit both in the same day, Tomecek said. The Oriskany, launched in 1950, was 911 feet (278 meters) in length.

“We're trying to be the best diving destination in the world,” Tomecek said.

The ship was decommissioned in 1969. Attempts by a hotel magnate and Norwegian Cruise Lines to use the ship never floated, and from 1996 until recently, it sat along a dock in Philadelphia.

“I’m just so happy that we are able to save parts of her,” Gibbs said.