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AstraZeneca and Daiichi's Breast Cancer Drug Meets Goal in Study

FILE PHOTO: Test tubes are seen in front of a displayed AstraZeneca logo in this illustration taken, May 21, 2021. REUTERS/Dado Ruvic/Illustration/File Photo/File Photo
FILE PHOTO: Test tubes are seen in front of a displayed AstraZeneca logo in this illustration taken, May 21, 2021. REUTERS/Dado Ruvic/Illustration/File Photo/File Photo
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AstraZeneca and Daiichi's Breast Cancer Drug Meets Goal in Study

FILE PHOTO: Test tubes are seen in front of a displayed AstraZeneca logo in this illustration taken, May 21, 2021. REUTERS/Dado Ruvic/Illustration/File Photo/File Photo
FILE PHOTO: Test tubes are seen in front of a displayed AstraZeneca logo in this illustration taken, May 21, 2021. REUTERS/Dado Ruvic/Illustration/File Photo/File Photo

AstraZeneca said on Friday its experimental precision drug had slowed the progression of a common type of breast cancer in a late-stage trial, a boost for the company after its shares fell in July on results from a separate trial of the same drug for lung cancer.
The drug, datopotamab deruxtecan, which AstraZeneca is jointly developing with Japan's Daiichi Sankyo, is being closely watched by analysts and investors in part due to the promise of the class of drugs to which it belongs, known as antibody drug conjugates (ADC).
ADCs consist of tumor-seeking monoclonal antibodies that are combined with a cell-killing chemotherapy payload.
The trial data released on Friday showed the drug, abbreviated as Dato-DXd, demonstrated a statistically significant and clinically meaningful improvement in slowing the progression of a type of breast cancer in trial participants, compared to patients who received other treatments such as chemotherapy.
The trial focused on tumors that grow in response to the hormones estrogen or progesterone, which account for roughly two-thirds of breast cancer cases. The study participants' disease had spread to other parts of the body.
The British drugmaker also said that there was a "trend in improvement" in the other main goal of the study, "overall survival" of patients, but the data on that was not mature so the trial would continue as planned.
AstraZeneca shares rose 1.7% in early trading, to their highest level in more than five weeks.
AstraZeneca is simultaneously developing the drug for use in lung cancer, and while data from a separate late-stage trial released in July was positive, the market was concerned that the drug's benefits for use in lung cancer treatment might not as pronounced as hoped, leading shares to fall more than 6% on the day the data was released.
The company has not said when it will release detailed data from the lung cancer study.
Analysts see the positive results from the breast cancer trial as good for AstraZeneca, but the market is more focused on the results of a trial called MARIPOSA by Johnson & Johnson. It compares AstraZeneca’s blockbuster cancer drug Tagrisso alone with its own drug, Rybrevant, in combination with another medicine.
Those results are expected later this year.

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Japan City Gets $3.6 Mn Donation in Gold to Fix Water System

FILE PHOTO: Factories line the port of Osaka, western Japan October 23, 2017. REUTERS/Thomas White/File Photo
FILE PHOTO: Factories line the port of Osaka, western Japan October 23, 2017. REUTERS/Thomas White/File Photo
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Japan City Gets $3.6 Mn Donation in Gold to Fix Water System

FILE PHOTO: Factories line the port of Osaka, western Japan October 23, 2017. REUTERS/Thomas White/File Photo
FILE PHOTO: Factories line the port of Osaka, western Japan October 23, 2017. REUTERS/Thomas White/File Photo

Osaka has received an unusual donation -- 21 kilograms of gold -- to pay for the maintenance of its ageing water system, the Japanese commercial hub announced Thursday.

The donation worth $3.6 million was made in November by a person who a month earlier had already given $3,300 in cash for the municipal waterworks, Osaka Mayor Hideyuki Yokoyama told a press conference.

"It's an absolutely staggering amount," said Yokoyama, adding that he was lost for words to express his gratitude.

"I was shocked."

The donor wished to remain anonymous, AFP quoted the mayor as saying.

Work to replace water pipes in Osaka, a city of 2.8 million residents, has hit a snag as the actual cost exceeded the planned budget, according to local media.

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Thai Cops Go Undercover as Lion Dancers to Nab Suspected Thief

People gather to watch performers outside Emsphere shopping mall on the first day of the Lunar New Year of the Horse, in Bangkok on February 17, 2026. (Photo by Lillian SUWANRUMPHA / AFP)
People gather to watch performers outside Emsphere shopping mall on the first day of the Lunar New Year of the Horse, in Bangkok on February 17, 2026. (Photo by Lillian SUWANRUMPHA / AFP)
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Thai Cops Go Undercover as Lion Dancers to Nab Suspected Thief

People gather to watch performers outside Emsphere shopping mall on the first day of the Lunar New Year of the Horse, in Bangkok on February 17, 2026. (Photo by Lillian SUWANRUMPHA / AFP)
People gather to watch performers outside Emsphere shopping mall on the first day of the Lunar New Year of the Horse, in Bangkok on February 17, 2026. (Photo by Lillian SUWANRUMPHA / AFP)

Thai police donned a lion dance costume during this week's Lunar New Year festivities to arrest a suspect accused of stealing about $64,000 worth of Buddhist artifacts, police said Thursday.

Officers dressed as a red-and-yellow lion made the arrest on Wednesday evening after receiving a report earlier this month of a home burglary in the suburbs of the capital, Bangkok, AFP reported.

Capital police said the reported break-in involved "numerous Buddhist objects and two 12-inch Buddha statues", along with evidence of repeated attempts to enter the house, according to a statement.

With few leads, police kept watch for weeks before hatching an unusual plan to join a lion dance procession at a nearby Buddhist temple.

"Officers gradually moved closer to the suspect before arresting him," police said.

A video released by police showed the festive lion dancers approaching the suspect before an officer suddenly emerged from the head of the costume and, with help from colleagues, pinned him to the ground.

Police estimated the value of the stolen items at around two million baht ($64,000).

The suspect, a 33-year-old man, has a criminal record involving drug offences and theft, police added.

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Sudan's Historic Acacia Forest Devastated as War Fuels Logging

Little is left of the once sprawling acacia forest south of Sudan's capital. Ebrahim Hamid / AFP
Little is left of the once sprawling acacia forest south of Sudan's capital. Ebrahim Hamid / AFP
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Sudan's Historic Acacia Forest Devastated as War Fuels Logging

Little is left of the once sprawling acacia forest south of Sudan's capital. Ebrahim Hamid / AFP
Little is left of the once sprawling acacia forest south of Sudan's capital. Ebrahim Hamid / AFP

Vast stretches of a once-verdant acacia forest south of Sudan's capital Khartoum have been reduced to little more than fields of stumps as nearly three years of conflict have fueled deforestation.

What was once a 1,500-hectare natural reserve has been "completely wiped out", Boushra Hamed, head of environmental affairs for Khartoum state, told AFP.

Al-Sunut forest had long served as a haven for migratory birds and a vital green shield against the Nile's seasonal floods.

"During the war, Khartoum state has lost 60 percent of its green cover," Hamed said, describing how century-old trees "were cut down with electric saws" for commercial timber and charcoal production.

Where tall acacias once cast cool shade over a wetland just upstream from the confluence of the Blue and White Nile, barren ground now lies exposed, criss-crossed by people gathering whatever wood remains.

Hamed called it "methodical destruction", though the perpetrators remain unknown and there has been no investigation.

Similar devastation is unfolding across several regions -- including western Darfur, neighboring Kordofan and the central states of Sennar and Al-Jazirah -- as insecurity and economic collapse drive unchecked logging, according to Sudan's Forests National Corporation.

According to a 2019 study by the Nairobi-based African Forest Forum, Sudan had already lost nearly half of its forested land since 1960 due to agricultural expansion, firewood collection and overgrazing.

By 2015, the country ranked among Africa's least forested nations, with around 10 percent of its territory still covered by woodland, the study said.

The report had also warned of further degradation if reforestation and sustainable management efforts were not implemented -- concerns now compounded by the ongoing conflict.

- 'Barrier' -

Aboubakr Al-Tayeb, who oversees Khartoum's forestry administration, said the damage "affects not only Khartoum, but Sudan and the wider African continent."

"The forest was home to several migratory species from Europe," he told AFP.

More than a hundred bird species, including ducks, geese, terns, ibis, herons, eagles and vultures, had been recorded in the area, alongside monkeys and small mammals.

Al-Nazir Ali Babiker, an agronomist, said the loss of tree cover could cause more severe seasonal flooding because the "forest acted as a barrier" against rising waters.

Flooding strikes Sudan every year, destroying homes, farmland and infrastructure and leaving many families with no choice but to flee to safer areas.

The war in Sudan, which erupted in April 2023, has already killed tens of thousands, displaced 11 million and shattered critical infrastructure.

Before the fighting, forests supplied roughly 70 percent of Sudan's energy consumption, primarily through charcoal and firewood, according to data from the African Forest Forum.

Al-Sunut had also been a popular leisure spot for Khartoum residents.

"We used to come in groups to study and have a good time," recalls Adam Hafiz Ibrahim, a student at Omdurman Islamic University.

Today, wood gatherers have supplanted the usual walkers. Disregarding army notices alerting them to landmines, men and women traverse the dry, open ground that now stands where the ancient forest once grew.

"We're not cutting the trees. We just pick up whatever wood's already on the ground to use for the fire," said Nafisa, a woman in her forties navigating the dry grasslands.

"We found the trees down. We collect the wood to sell to bakeries and families," said Mohamed Zakaria, a construction worker who lost his job because of the war.

Experts say that the economic hardship caused by the war combined with a lack of enforcement has encouraged logging.

"The logging continues, because those responsible for forest protection cannot access many areas," said Mousa el-Sofori, head of Sudan's Forests National Corporation.

Efforts to replant acacias are underway, Tayeb of the Khartoum forestry administration said, but seedlings grow slowly and can take years to mature.

Restoring the lost woodlands would be "long and costly", said Sofori.

"Some of these forests were centuries old," he added.