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AstraZeneca and Daiichi's Breast Cancer Drug Meets Goal in Study

FILE PHOTO: Test tubes are seen in front of a displayed AstraZeneca logo in this illustration taken, May 21, 2021. REUTERS/Dado Ruvic/Illustration/File Photo/File Photo
FILE PHOTO: Test tubes are seen in front of a displayed AstraZeneca logo in this illustration taken, May 21, 2021. REUTERS/Dado Ruvic/Illustration/File Photo/File Photo
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AstraZeneca and Daiichi's Breast Cancer Drug Meets Goal in Study

FILE PHOTO: Test tubes are seen in front of a displayed AstraZeneca logo in this illustration taken, May 21, 2021. REUTERS/Dado Ruvic/Illustration/File Photo/File Photo
FILE PHOTO: Test tubes are seen in front of a displayed AstraZeneca logo in this illustration taken, May 21, 2021. REUTERS/Dado Ruvic/Illustration/File Photo/File Photo

AstraZeneca said on Friday its experimental precision drug had slowed the progression of a common type of breast cancer in a late-stage trial, a boost for the company after its shares fell in July on results from a separate trial of the same drug for lung cancer.
The drug, datopotamab deruxtecan, which AstraZeneca is jointly developing with Japan's Daiichi Sankyo, is being closely watched by analysts and investors in part due to the promise of the class of drugs to which it belongs, known as antibody drug conjugates (ADC).
ADCs consist of tumor-seeking monoclonal antibodies that are combined with a cell-killing chemotherapy payload.
The trial data released on Friday showed the drug, abbreviated as Dato-DXd, demonstrated a statistically significant and clinically meaningful improvement in slowing the progression of a type of breast cancer in trial participants, compared to patients who received other treatments such as chemotherapy.
The trial focused on tumors that grow in response to the hormones estrogen or progesterone, which account for roughly two-thirds of breast cancer cases. The study participants' disease had spread to other parts of the body.
The British drugmaker also said that there was a "trend in improvement" in the other main goal of the study, "overall survival" of patients, but the data on that was not mature so the trial would continue as planned.
AstraZeneca shares rose 1.7% in early trading, to their highest level in more than five weeks.
AstraZeneca is simultaneously developing the drug for use in lung cancer, and while data from a separate late-stage trial released in July was positive, the market was concerned that the drug's benefits for use in lung cancer treatment might not as pronounced as hoped, leading shares to fall more than 6% on the day the data was released.
The company has not said when it will release detailed data from the lung cancer study.
Analysts see the positive results from the breast cancer trial as good for AstraZeneca, but the market is more focused on the results of a trial called MARIPOSA by Johnson & Johnson. It compares AstraZeneca’s blockbuster cancer drug Tagrisso alone with its own drug, Rybrevant, in combination with another medicine.
Those results are expected later this year.

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Billy Crystal, Mandy Moore Among Those who Lost Homes in Los Angeles Fires

A blackened US flag flies above a charred structure after the passage of the Palisades Fire in Pacific Palisades, California, on January 8, 2025. (Photo by AGUSTIN PAULLIER / AFP)
A blackened US flag flies above a charred structure after the passage of the Palisades Fire in Pacific Palisades, California, on January 8, 2025. (Photo by AGUSTIN PAULLIER / AFP)
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Billy Crystal, Mandy Moore Among Those who Lost Homes in Los Angeles Fires

A blackened US flag flies above a charred structure after the passage of the Palisades Fire in Pacific Palisades, California, on January 8, 2025. (Photo by AGUSTIN PAULLIER / AFP)
A blackened US flag flies above a charred structure after the passage of the Palisades Fire in Pacific Palisades, California, on January 8, 2025. (Photo by AGUSTIN PAULLIER / AFP)

Fires burning in and around Los Angeles have claimed the homes of numerous celebrities, including Billy Crystal, Mandy Moore and Paris Hilton and led to sweeping disruptions of entertainment events.
Three awards ceremonies planned for this weekend have been postponed. Next week's Oscar nominations have been delayed. And tens of thousands of Angelenos are displaced and awaiting word Thursday on whether their homes survived the flames — some of them the city's most famous denizens, The Associated Press reported.
More than 1,900 structures have been destroyed and the number is expected to increase. More than 130,000 people are also under evacuation orders in the metropolitan area, from the Pacific Coast inland to Pasadena, a number that continues to shift as new fires erupt.
Late Wednesday, a fire in the Hollywood Hills was scorching the hills near the famed Hollywood Bowl and Dolby Theatre, which is the home of the Academy Awards.
Here are how the fires are impacting celebrities and the Los Angeles entertainment industry:
Stars whose homes have burned in the fires Celebrities like Crystal and his wife, Janice, were sharing memories of the homes they lost.
The Crystals lost the home in the Pacific Palisades neighborhood that they lived in for 45 years.
“Janice and I lived in our home since 1979. We raised our children and grandchildren here. Every inch of our house was filled with love. Beautiful memories that can’t be taken away. We are heartbroken of course but with the love of our children and friends we will get through this,” the Crystals wrote in the statement.
Mandy Moore lost her home in the Altadena neighborhood roughly 30 miles east of the Palisades.
“Honestly, I’m in shock and feeling numb for all so many have lost, including my family. My children’s school is gone. Our favorite restaurants, leveled. So many friends and loved ones have lost everything too,” Moore wrote on Instagram in a post that included video of devastated streets in the foothill suburb.
“Our community is broken but we will be here to rebuild together. Sending love to all affected and on the front lines trying to get this under control,” Moore wrote.
Hilton posted a news video clip on Instagram and said it included footage of her destroyed home in Malibu. “This home was where we built so many precious memories. It’s where Phoenix took his first steps and where we dreamed of building a lifetime of memories with London,” she said, referencing her young children."
Elwes, the star of “The Princess Bride” and numerous other films, wrote on Instagram Wednesday that his family was safe but their home had burned in the coastal Palisades fire. “Sadly we did lose our home but we are grateful to have survived this truly devastating fire,” Elwes wrote.
The blazes have thrown Hollywood's carefully orchestrated awards season into disarray.
Awards ceremonies planned for this weekend have been postponed due to the fires. The AFI Awards, which were set to honor “Wicked,” “Anora” and other awards season contenders, had been scheduled for Friday.
The AARP Movies for Grownups Awards, which honor movies and television shows that resonate with older audiences, were set for Friday but have been postponed.
The Critics Choice Awards, originally scheduled for Sunday, have been postponed until Feb. 26.
Each of the shows feature projects that are looking for any advantage they can get in the Oscar race and were scheduled during the Academy Awards voting window.
The Oscar nominations are also being delayed two days to Jan. 19 and the film academy has extended the voting window to accommodate members affected by the fires.