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Berlin Zoo Hopes for More German-born Giant Pandas as Scans Confirm Pregnancy

FILE -In this April 5, 2019 file photo taken through a window female panda Meng Meng eats bamboo at its enclosure at the zoo in Berlin, Germany. (AP Photo/Michael Sohn, file)
FILE -In this April 5, 2019 file photo taken through a window female panda Meng Meng eats bamboo at its enclosure at the zoo in Berlin, Germany. (AP Photo/Michael Sohn, file)
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Berlin Zoo Hopes for More German-born Giant Pandas as Scans Confirm Pregnancy

FILE -In this April 5, 2019 file photo taken through a window female panda Meng Meng eats bamboo at its enclosure at the zoo in Berlin, Germany. (AP Photo/Michael Sohn, file)
FILE -In this April 5, 2019 file photo taken through a window female panda Meng Meng eats bamboo at its enclosure at the zoo in Berlin, Germany. (AP Photo/Michael Sohn, file)

The Berlin Zoo has much anticipated news: Meng Meng the panda is pregnant again, months after the first giant pandas born in Germany were sent to China, The Associated Press reported.
The zoo said Tuesday that ultrasound scans over the weekend showed Meng Meng is expecting two cubs. They still have plenty of growing to do but the zoo expects the birth at the end of August, if all goes well, it said.
Meng Meng and male panda Jiao Qing arrived in Berlin in 2017. In August 2019, Meng Meng gave birth to Pit and Paule, also known by the Chinese names Meng Xiang und Meng Yuan, the first giant pandas born in Germany.
The twins were a star attraction in Berlin, but they were flown to China in December — a trip that was contractually agreed from the start but delayed by the COVID-19 pandemic. China gifted friendly nations with its unofficial mascot for decades as part of a “panda diplomacy″ policy. The country now loans pandas to zoos on commercial terms.
Giant pandas have difficulty breeding and births are particularly welcomed. There are about 1,800 pandas living in the wild in China and a few hundred in captivity worldwide.
Meng Meng was artificially inseminated in March. The zoo noted that female pandas are only capable of reproducing for about 72 hours per year.

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FDA Approves First Nasal Spray to Treat Dangerous Allergic Reactions

Signage is seen outside of the Food and Drug Administration (FDA) headquarters in White Oak, Maryland, US, August 29, 2020. REUTERS/Andrew Kelly/File Photo Purchase Licensing Rights
Signage is seen outside of the Food and Drug Administration (FDA) headquarters in White Oak, Maryland, US, August 29, 2020. REUTERS/Andrew Kelly/File Photo Purchase Licensing Rights
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FDA Approves First Nasal Spray to Treat Dangerous Allergic Reactions

Signage is seen outside of the Food and Drug Administration (FDA) headquarters in White Oak, Maryland, US, August 29, 2020. REUTERS/Andrew Kelly/File Photo Purchase Licensing Rights
Signage is seen outside of the Food and Drug Administration (FDA) headquarters in White Oak, Maryland, US, August 29, 2020. REUTERS/Andrew Kelly/File Photo Purchase Licensing Rights

US health officials on Friday approved a nasal spray to treat severe allergic reactions, the first needle-free alternative to shots like EpiPen.

The Food and Drug Administration said it approved the spray from drugmaker ARS Pharmaceuticals Inc. as an emergency treatment for adults and older children experiencing life-threatening allergic reactions known as anaphylaxis, The AP reported.

Anaphylaxis occurs when the body's immune system develops a sudden, unexpected reaction to a foreign substance, such as food, insect stings or medications. Common symptoms include hives, swelling, itching, vomiting and difficulty breathing.

The device, marketed as Neffy, could upend treatment for the 33 million to 45 million Americans with severe allergies to food and other triggers. Anaphylaxis sends more than 30,000 people to emergency rooms and results in more than 2,000 hospitalizations and more than 230 deaths in the US each year.

Of the 6 million prescriptions written for auto-injectors each year, more than 40% are never filled, Dr. Thomas Casale, an allergist at the University of South Florida, told an FDA advisory panel last year. Even when they are available to caregivers, many auto-injectors are used incorrectly, he said.

“There’s a real unmet medical need for a large portion of the population,” he said.

Neffy is intended for people who weigh at least 66 pounds. It is given in a single dose sprayed into one nostril. A second dose can be given if the person’s symptoms don’t improve.

The new treatment could be life-changing for people with severe food allergies, said Dr. Kelly Cleary, a pediatrician and director with the Food Allergy Research & Education, a nonprofit advocacy group.

“I have seen the look of worry or fear,” said Cleary, whose 11-year-old son has multiple food allergies. “I worry about what happens if someone hesitates.”

Requiring an injection in an emergency is as scary to some children as the allergic reaction itself. Some parents have had to restrain thrashing children to inject them, sometimes causing cuts that require stitches. About 3,500 caregivers a year are injured when they accidentally inject themselves in the hands, ARS said.

Priscilla Hernandez, of Pasadena, California said her 12-year-old son, Zacky, who is allergic to sesame, peanuts, tree nuts, avocado and other foods, was traumatized when he had a reaction at school about six years ago and a nurse treated him with an auto-injector.

“Having to do a shot creates this whole different level of anxiety,” she said.

She said, “we are over the moon” about the FDA's approval of the spray, which Zacky will start carrying when it becomes available.

First marketed in 1901, epinephrine predates the FDA itself. Products like the EpiPen auto-injector, approved in 1987, were authorized based on chemistry and manufacturing data and were not required to prove safety and efficacy.

Clinical trials of people experiencing potentially deadly reactions are difficult for ethical and pragmatic reasons. Instead, ARS officials compared the effect of the nasal spray on biological markers to existing epinephrine treatments.

Results showed Neffy worked about as well as injected epinephrine to boost heart rate and blood pressure, which counter severe reactions. The drug is combined with a patented agent that allows it to be easily absorbed through nasal membranes.