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Blood Tests Allow 30-year Estimates of Women's Cardio Risks, New Study Says

A woman jogs in a park in Saint-Sebastien-sur-Loire near Nantes, France January 19, 2024. REUTERS/Stephane Mahe/File Photo Purchase Licensing Rights
A woman jogs in a park in Saint-Sebastien-sur-Loire near Nantes, France January 19, 2024. REUTERS/Stephane Mahe/File Photo Purchase Licensing Rights
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Blood Tests Allow 30-year Estimates of Women's Cardio Risks, New Study Says

A woman jogs in a park in Saint-Sebastien-sur-Loire near Nantes, France January 19, 2024. REUTERS/Stephane Mahe/File Photo Purchase Licensing Rights
A woman jogs in a park in Saint-Sebastien-sur-Loire near Nantes, France January 19, 2024. REUTERS/Stephane Mahe/File Photo Purchase Licensing Rights

Women’s heart disease risks and their need to start taking preventive medications should be evaluated when they are in their 30s rather than well after menopause as is now the practice, said researchers who published a study on Saturday.

Presenting the findings at the European Society of Cardiology annual meeting in London, they said the study showed for the first time that simple blood tests make it possible to estimate a woman’s risk of cardiovascular disease over the next three decades.

"This is good for patients first and foremost, but it is also important information for (manufacturers of) cholesterol lowering drugs, anti-inflammatory drugs, and lipoprotein(a)lowering drugs - the implications for therapy are broad," said study leader Dr. Paul Ridker of Brigham and Women’s Hospital in Boston, Reuters reported.

Current guidelines “suggest to physicians that women should generally not be considered for preventive therapies until their 60s and 70s. These new data... clearly demonstrate that our guidelines need to change,” Ridker said. “We must move beyond discussions of 5 or 10 year risk."

The 27,939 participants in the long-term Women’s Health Initiative study had blood tests between 1992 and 1995 for low density lipoprotein cholesterol (LDL-C or “bad cholesterol”), which are already a part of routine care.

They also had tests for high-sensitivity C-reactive protein (hsCRP) - a marker of blood vessel inflammation - and lipoprotein(a), a genetically determined type of fat.

Compared to risks in women with the lowest levels of each marker, risks for major cardiovascular events like heart attacks or strokes over the next 30 years were 36% higher in women with the highest levels of LDL-C, 70% higher in women with the highest levels of hsCRP, and 33% higher in those with the highest levels of lipoprotein(a).

Women in whom all three markers were in the highest range were 2.6 times more likely to have a major cardiovascular event and 3.7 times more likely to have a stroke over the next three decades, according to a report of the study in The New England Journal of Medicine published to coincide with the presentation at the meeting.

“The three biomarkers are fully independent of each other and tell us about different biologic issues each individual woman faces,” Ridker said.

“The therapies we might use in response to an elevation in each biomarker are markedly different, and physicians can now specifically target the individual person’s biologic problem.”

While drugs that lower LDL-C and hsCRP are widely available - including statins and certain pills for high blood pressure and heart failure - drugs that reduce lipoprotein(a) levels are still in development by companies, including Novartis , Amgen , Eli Lilly and London-based Silence Therapeutics.

In some cases, lifestyle changes such as exercising and quitting smoking can be helpful.

Most of the women in the study were white Americans, but the findings would likely “have even greater impact among Black and Hispanic women for whom there is even a higher prevalence of undetected and untreated inflammation,” Ridker said.

“This is a global problem,” he added. “We need universal screening for hsCRP ... and for lipoprotein(a), just as we already have universal screening for cholesterol.”

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Spider-Like Scar Haunts Jupiter's Moon Europa

A dendritic “lab star” formed by liquid water flowing through Europa ice simulant at NASA JPL, modeling how features like Damhán Alla could form on Jupiter's icy moon, similar to how lake stars form on Earth. (Image credit: Prof. Lauren Mc Keown.)
A dendritic “lab star” formed by liquid water flowing through Europa ice simulant at NASA JPL, modeling how features like Damhán Alla could form on Jupiter's icy moon, similar to how lake stars form on Earth. (Image credit: Prof. Lauren Mc Keown.)
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Spider-Like Scar Haunts Jupiter's Moon Europa

A dendritic “lab star” formed by liquid water flowing through Europa ice simulant at NASA JPL, modeling how features like Damhán Alla could form on Jupiter's icy moon, similar to how lake stars form on Earth. (Image credit: Prof. Lauren Mc Keown.)
A dendritic “lab star” formed by liquid water flowing through Europa ice simulant at NASA JPL, modeling how features like Damhán Alla could form on Jupiter's icy moon, similar to how lake stars form on Earth. (Image credit: Prof. Lauren Mc Keown.)

Scientists have explored a strange, spider-like scar on Jupiter's icy moon Europa, suggesting the feature might have formed from briny water eruptions beneath the moon's ice.

NASA's Galileo spacecraft, whose mission ended in 2003, spotted the unique feature - officially named Damhán Alla, an Irish word meaning “spider” or “wall demon” - within Europa's Manannán crater.

The starburst-like pattern first appeared in images captured by the spacecraft in the late 1990s, but scientists are only now piecing together how it may have formed, according to a statement from Trinity College Dublin.

“The significance of our research is really exciting,” Lauren Mc Keown, lead author of a study published in The Planetary Science Journal.

“Surface features like these can tell us a lot about what's happening beneath the ice. If we see more of them with Europa Clipper, they could point to local brine pools below the surface.”

On Earth, lake stars emerge when snow falls on frozen lakes and holes form in the ice, allowing water to flow upwards and melt surrounding snow, carving radial, branching channels as it spreads.

Such patterns are common in nature, from lightning scars to tidal channels, illustrating the movement of fluids and energy through different surfaces.

The researchers suggest that Europa's version might form the same way - except the liquid in this case would be salty brine forced upward after an impact disrupted the ice shell.

“Lake stars are really beautiful, and they are pretty common on snow or slush-covered frozen lakes and ponds,” McKeown said in the statement. “It is wonderful to think that they may give us a glimpse into processes occurring on Europa and maybe even other icy ocean worlds in our solar system.”

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‘Like Skiing’: First Urban Cable Car Unveiled Outside Paris

This photograph shows the first urban cable car "C1" in Ile-de-France region during its official launch, in between Creteil Pointe du Lac and Villeneuve-Saint-Georges, on the outskirts of Paris on December 13, 2025. (AFP)
This photograph shows the first urban cable car "C1" in Ile-de-France region during its official launch, in between Creteil Pointe du Lac and Villeneuve-Saint-Georges, on the outskirts of Paris on December 13, 2025. (AFP)
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‘Like Skiing’: First Urban Cable Car Unveiled Outside Paris

This photograph shows the first urban cable car "C1" in Ile-de-France region during its official launch, in between Creteil Pointe du Lac and Villeneuve-Saint-Georges, on the outskirts of Paris on December 13, 2025. (AFP)
This photograph shows the first urban cable car "C1" in Ile-de-France region during its official launch, in between Creteil Pointe du Lac and Villeneuve-Saint-Georges, on the outskirts of Paris on December 13, 2025. (AFP)

Gondolas floated above a cityscape in the southeastern suburbs of Paris on Saturday as officials unveiled the first urban cable car in the French capital's region.

Authorities inaugurated the C1 line in the suburb of Limeil-Brevannes in the presence of Valerie Pecresse, the head of the Ile-de-France region, and the mayors of the towns served by the cable car.

The 4.5-kilometer route connects Creteil to Villeneuve-Saint-Georges and passes through Limeil-Brevannes and Valenton.

Historically used to cross rugged mountain terrain, such systems are increasingly being used to link up isolated neighborhoods.

"It's like skiing!" joked Ibrahim Bamba, a 20-year-old student who lives in Limeil-Brevannes which is not served by the Paris metro or any rail network.

"It's the Alps on the Marne!" said Pecresse, referring to the department of Val-de-Marne located in the Grand Paris metropolis.

The cable car will carry some 11,000 passengers per day in its 105 gondolas, each able to accommodate ten passengers.

The total journey will take 18 minutes, including stops along the way, compared to around 40 minutes by bus or car, connecting the isolated neighborhoods to the Paris metro line 8. A ride requires a bus ticket or travel pass used for the Paris metro.

"This is a great step forward in terms of transportation. The roads are often congested in the morning," said Salimatou Bah, 52, who has lived in Limeil-Brevannes for thirteen years.

"We wondered if people would be hesitant, but I think it just takes a little time to adapt."

- 'Urban divides' -

Pecresse said the project was the result of "a 10-year obstacle course."

"We had to find the funding, convince local residents," she said. "For the inhabitants of Val-de-Marne, it's a sign of consideration."

The 138-million-euro project was cheaper to build than a subway, officials said.

"An underground metro would never have seen the light of day because the budget of more than billion euros could never have been financed," said Gregoire de Lasteyrie, vice-president of the Ile-de-France regional council in charge of transport.

Each cabin can accommodate ten seated passengers as well as wheelchairs, bicycles, and strollers. Inside, video surveillance and emergency call buttons have been installed to ensure passenger safety in addition to staff at each station.

The cable car is a response to "urban divides" in neighborhoods that were "lacking in terms of public transport," said Metin Yavuz, mayor of Valenton, a town of 16,000 inhabitants.

It is France's seventh urban cable car, with aerial tramways already operating in cities including Brest, Saint-Denis de La Reunion and Toulouse.

France's first urban cable car was built in Grenoble, nestled at the foot of the Alps, in 1934. The iconic "bubbles" have become one of the symbols of the southeastern city.

Cable cars are considered one of the safest means of transport in the world.

In France, the last fatal accident occurred in 1999 in the Hautes-Alpes, when 20 people lost their lives.

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Before Megalodon, Researchers Say a Monstrous Shark Ruled Ancient Australian Seas

A illustration made in Sept. 3, 2025, of a gigantic 8 meter (26 foot) long mega-predatory lamniform shark swimming beside a long-necked plesiosaur in the seas off Australia 115 million years ago. (Pollyanna von Knorring/Swedish Museum of Natural History via AP)
A illustration made in Sept. 3, 2025, of a gigantic 8 meter (26 foot) long mega-predatory lamniform shark swimming beside a long-necked plesiosaur in the seas off Australia 115 million years ago. (Pollyanna von Knorring/Swedish Museum of Natural History via AP)
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Before Megalodon, Researchers Say a Monstrous Shark Ruled Ancient Australian Seas

A illustration made in Sept. 3, 2025, of a gigantic 8 meter (26 foot) long mega-predatory lamniform shark swimming beside a long-necked plesiosaur in the seas off Australia 115 million years ago. (Pollyanna von Knorring/Swedish Museum of Natural History via AP)
A illustration made in Sept. 3, 2025, of a gigantic 8 meter (26 foot) long mega-predatory lamniform shark swimming beside a long-necked plesiosaur in the seas off Australia 115 million years ago. (Pollyanna von Knorring/Swedish Museum of Natural History via AP)

In the age of dinosaurs — before whales, great whites or the bus-sized megalodon — a monstrous shark prowled the waters off what's now northern Australia, among the sea monsters of the Cretaceous period.

Researchers studying huge vertebrae discovered on a beach near the city of Darwin say the creature is now the earliest known mega-predator of the modern shark lineage, living 15 million years earlier than enormous sharks found before.

And it was huge. The ancestor of today’s 6-meter (20-foot) great white shark was thought to be about 8 meters (26 feet) long, the authors of a paper published in the journal Communications Biology said.

“Cardabiodontids were ancient, mega-predatory sharks that are very, very common from the later part of the Cretaceous, after 100 million years ago,” said Benjamin Kear, the senior curator in paleobiology at the Swedish Museum of Natural History and one of the study’s authors. “But this has pushed the time envelope back of when we’re going to find absolutely enormous cardabiodontids.”

Sharks have a 400-million-year history but lamniforms, the ancestors of today’s great white sharks, appear in the fossil record from 135 million years ago. At that time they were small — probably only a meter in length — which made the discovery that lamniforms had already become gigantic by 115 million years ago an unexpected one for researchers.

The vertebrae were found on coastline near Darwin in Australia’s far north, once mud from the floor of an ancient ocean that stretched from Gondwana — now Australia — to Laurasia, which is now Europe. It’s a region rich in fossil evidence of prehistoric marine life, with long-necked plesiosaurs and ichthyosaurs among the creatures discovered so far.

The five vertebrae that launched the quest to estimate the size of their mega-shark owners were not a recent discovery, but an older one that had been somewhat overlooked, Kear said. Unearthed in the late 1980s and 1990s, the fossils measured 12 centimeters (4.7 inches) across and had been stored in a museum for years.

When studying ancient sharks, vertebrae are prizes for paleontologists. Shark skeletons are made of cartilage, not bone, and their fossil record is mostly made up of teeth, which sharks shed throughout their lives.

“The importance of vertebrae is they give us hints about size,” Kear said. “If you’re trying to scale it from teeth, it’s difficult. Are the teeth big and the bodies small? Are they big teeth with big bodies?”

Scientists have used mathematical formulas to estimate the size of extinct sharks like megalodon, a massive predator that came later and may have reached 17 meters (56 feet) in length, Kear said. But the rarity of vertebrae mean questions of ancient shark size are difficult to answer, he added.

The international research team spent years testing different ways to estimate the size of the Darwin cardabiodontids, using fisheries data, CT scans and mathematical models, Kear said. Eventually, they arrived at a likely portrait of the predator’s size and shape.

“It would’ve looked for all the world like a modern, gigantic shark, because this is the beauty of it,” Kear said. “This is a body model that has worked for 115 million years, like an evolutionary success story.”

The study of the Darwin sharks suggested that modern sharks rose early in their adaptive evolution to the top of prehistoric food chains, the researchers said. Now, scientists could scour similar environments worldwide for others, Kear said.

“They must have been around before,” he said. “This thing had ancestors.”

Studying ancient ecosystems like this one could help researchers understand how today’s species might respond to environmental change, Kear added.

“This is where our modern world begins,” he said. “By looking at what happened during past shifts in climate and biodiversity, we can get a better sense of what might come next.”