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Axsome's Alzheimer's-related Drug Shows Mixed Results in Late-stage Studies

The human brain. Illustration: AFP
The human brain. Illustration: AFP
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Axsome's Alzheimer's-related Drug Shows Mixed Results in Late-stage Studies

The human brain. Illustration: AFP
The human brain. Illustration: AFP

Axsome Therapeutics said on Monday its experimental drug to treat agitation related to Alzheimer's disease succeeded in one of the two late-stage studies and failed to meet the main goal of the second trial.

Shares of the drug developer, which was testing the treatment, AXS-05, dropped 12% in premarket trading, Reuters reported.

The agitation is a symptom that causes emotional distress as well as verbal and physical aggressiveness.

The treatment significantly delayed the time to relapse in agitation as measured on a disease severity scale in one study, but did not demonstrate statistical significance in delaying agitation in another late-stage trial.

AXS-05 was safe and well tolerated in both the studies, the company said.

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Buyer Splashes Out $1.3 Million for Tokyo New Year Tuna

The head of a 276-kilogram bluefin tuna that was auctioned for 207 million Japanese yen (about 1.3 million US dollars), which was bought jointly by sushi restaurant operator Onodera Group and wholesaler Yamayuki, is carried by a sushi chef at an Onodera sushi restaurant after the first tuna auction of the New Year in Tokyo, Japan January 5, 2025. (Reuters)
The head of a 276-kilogram bluefin tuna that was auctioned for 207 million Japanese yen (about 1.3 million US dollars), which was bought jointly by sushi restaurant operator Onodera Group and wholesaler Yamayuki, is carried by a sushi chef at an Onodera sushi restaurant after the first tuna auction of the New Year in Tokyo, Japan January 5, 2025. (Reuters)
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Buyer Splashes Out $1.3 Million for Tokyo New Year Tuna

The head of a 276-kilogram bluefin tuna that was auctioned for 207 million Japanese yen (about 1.3 million US dollars), which was bought jointly by sushi restaurant operator Onodera Group and wholesaler Yamayuki, is carried by a sushi chef at an Onodera sushi restaurant after the first tuna auction of the New Year in Tokyo, Japan January 5, 2025. (Reuters)
The head of a 276-kilogram bluefin tuna that was auctioned for 207 million Japanese yen (about 1.3 million US dollars), which was bought jointly by sushi restaurant operator Onodera Group and wholesaler Yamayuki, is carried by a sushi chef at an Onodera sushi restaurant after the first tuna auction of the New Year in Tokyo, Japan January 5, 2025. (Reuters)

The top bidder at a Tokyo fish market said they paid $1.3 million for a tuna on Sunday, the second highest price ever paid at an annual prestigious new year auction.

Michelin-starred sushi restauranteurs the Onodera Group said they paid 207 million yen for the 276-kilogram (608 pound) bluefin tuna, roughly the size and weight of a motorbike.

It is the second highest price paid at the opening auction of the year in Tokyo's main fish market since comparable data started being collected in 1999.

The powerful buyers have now paid the top price for five years straight -- winning bragging rights and a lucrative frenzy of media attention in Japan.

"The first tuna is something meant to bring in good fortune," Onodera official Shinji Nagao told reporters after the auction. "Our wish is that people will eat this and have a wonderful year."

The Onodera Group paid 114 million yen for the top tuna last year.

But the highest ever auction price was 333.6 million yen for a 278-kilogram bluefin in 2019, as the fish market was moved from its traditional Tsukiji area to a modern facility in nearby Toyosu.

The record bid was made by self-proclaimed "Tuna King" Kiyoshi Kimura, who operates the Sushi Zanmai national restaurant chain.

During the Covid-19 pandemic the new year tunas commanded only a fraction of their usual top prices, as the public were discouraged from dining out and restaurants had limited operations.